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Am I Having an RMS Relapse Again? See Some Common Signs

You’re doing everything right—you visit your healthcare provider regularly, you take your relapsing MS medication exactly as it is prescribed—so why does it feel like that’s still not enough? It could be that you’re continuing to experience frequent relapses—a sign that your treatment may not be working well enough.

Knowing when it’s a relapse

Relapses, also known as flare-ups, are when new or existing symptoms appear or worsen, lasting for at least 24 hours and sometimes for as long as several weeks or months. While MS affects everyone differently, there are some common symptoms that people may experience during a relapse. Perhaps you’ve experienced one or more of the following symptoms.

Accepting frequent relapses as “just part of living with relapsing MS” is not a good plan. If you’re on a treatment but still feel like you’re experiencing too many relapses, it could be time for you to learn about LEMTRADA.

LEMTRADA is not approved to treat individual symptoms of a relapse. Click below to read about the LEMTRADA study and plan to have a discussion with your healthcare provider about your relapsing MS and treatment goals.

Accepting frequent relapses as “just part of living with relapsing MS” is not a good plan. If you’re on a treatment but still feel like you’re experiencing too many relapses, it could be time for you to learn about LEMTRADA.

LEMTRADA is not approved to treat individual symptoms of a relapse. Click below to read about the LEMTRADA study and plan to have a discussion with your healthcare provider about your relapsing MS and treatment goals.

Accepting frequent relapses as “just part of living with relapsing MS” is not a good plan. If you’re on a treatment but still feel like you’re experiencing too many relapses, it could be time for you to learn about LEMTRADA.

LEMTRADA is not approved to treat individual symptoms of a relapse. Click below to read about the LEMTRADA study and plan to have a discussion with your healthcare provider about your relapsing MS and treatment goals.

Accepting frequent relapses as “just part of living with relapsing MS” is not a good plan. If you’re on a treatment but still feel like you’re experiencing too many relapses, it could be time for you to learn about LEMTRADA.

LEMTRADA is not approved to treat individual symptoms of a relapse. Click below to read about the LEMTRADA study and plan to have a discussion with your healthcare provider about your relapsing MS and treatment goals.

Accepting frequent relapses as “just part of living with relapsing MS” is not a good plan. If you’re on a treatment but still feel like you’re experiencing too many relapses, it could be time for you to learn about LEMTRADA.

LEMTRADA is not approved to treat individual symptoms of a relapse. Click below to read about the LEMTRADA study and plan to have a discussion with your healthcare provider about your relapsing MS and treatment goals.

IMPORTANT SAFETY INFORMATION

LEMTRADA can cause serious side effects including:

Serious autoimmune problems: Some people receiving LEMTRADA develop a condition where the immune cells in your body attack other cells or organs in the body (autoimmunity), which can be serious and may cause death. Serious autoimmune problems may include:

  • Immune thrombocytopenic purpura (ITP), a condition of reduced platelet counts in your blood that can cause severe bleeding that may cause life‑threatening problems. Call your healthcare provider right away if you have any of the following symptoms: easy bruising; bleeding from a cut that is hard to stop; coughing up blood; heavier menstrual periods than normal; bleeding from your gums or nose that is new or takes longer than usual to stop; small, scattered spots on your skin that are red, pink, or purple
  • Kidney problems called anti‑glomerular basement membrane disease, which, if not treated, can lead to severe kidney damage, kidney failure that needs dialysis, a kidney transplant, or death. Call your healthcare provider right away if you have any of the following symptoms: swelling of your legs or feet; blood in the urine (red or tea‑colored urine); decrease in urine; fatigue; coughing up blood

It is important for you to have blood and urine tests before you receive, while you are receiving and every month for 4 years or longer, after you receive your last LEMTRADA infusion.

Serious infusion reactions: LEMTRADA can cause serious infusion reactions that may cause death. Serious infusion reactions may happen while you receive, or up to 24 hours or longer after you receive LEMTRADA.

  • You will receive your infusion at a healthcare facility with equipment and staff trained to manage infusion reactions, including serious allergic reactions, and urgent heart or breathing problems. You will be watched while you receive, and for 2 hours or longer after you receive, LEMTRADA. If a serious infusion reaction happens while you are receiving LEMTRADA, your infusion may be stopped.

Tell your healthcare provider right away if you have any of the following symptoms of a serious infusion reaction during the infusion, and after you have left the healthcare facility:

  • swelling in your mouth or throat
  • trouble breathing
  • weakness
  • fast, slow, or irregular heartbeat
  • chest pain
  • rash

To lower your chances of getting a serious infusion reaction, your healthcare provider will give you a medicine called corticosteroids before your first 3 infusions of a treatment course. You may also be given other medicines before or after the infusion to try to reduce your chances of having these reactions or to treat them if they happen.

Stroke and tears in your arteries that supply blood to your brain (carotid and vertebral arteries): Some people have had serious and sometimes deadly strokes and tears in their carotid or vertebral arteries within 3 days of receiving LEMTRADA. Get help right away if you have any of the following symptoms that may be signs of a stroke or tears in your carotid or vertebral arteries:

  • drooping of parts of your face
  • weakness on one side
  • sudden severe headache
  • difficulty with speech
  • neck pain

Certain cancers: Receiving LEMTRADA may increase your chance of getting some kinds of cancers, including thyroid cancer, skin cancer (melanoma), and blood cancers called lymphoproliferative disorders and lymphoma. Call your healthcare provider if you have the following symptoms that may be a sign of thyroid cancer:

  • new lump
  • swelling in your neck
  • pain in front of neck
  • hoarseness or other voice changes that do not go away
  • trouble swallowing or breathing
  • cough that is not caused by a cold

Have your skin checked before you start receiving LEMTRADA and each year while you are receiving treatment to monitor for symptoms of skin cancer.

Because of risks of autoimmunity, infusion reactions, and some kinds of cancers, LEMTRADA is only available through a restricted program called the LEMTRADA Risk Evaluation and Mitigation Strategy (REMS) Program.

Do not receive LEMTRADA if you are infected with human immunodeficiency virus (HIV).

Thyroid problems: Some patients taking LEMTRADA may get an overactive thyroid (hyperthyroidism) or an underactive thyroid (hypothyroidism). Call your healthcare provider if you have any of these symptoms:

  • excessive sweating
  • unexplained weight loss
  • fast heartbeat
  • eye swelling
  • nervousness
  • unexplained weight gain
  • feeling cold
  • worsening tiredness
  • constipation

Low blood counts (cytopenias): LEMTRADA may cause a decrease in some types of blood cells. Some people with these low blood counts have increased infections. Call your doctor right away if you have symptoms of cytopenias such as:

  • weakness
  • chest pain
  • yellowing of the skin or whites of the eyes (jaundice)
  • dark urine
  • fast heartbeat

Inflammation of the liver: Call your healthcare provider right away if you have symptoms such as unexplained nausea, stomach pain, tiredness, loss of appetite, yellowing of skin or whites of eyes, or bleeding or bruising more easily than normal.

Serious infections: LEMTRADA may cause you to have a serious infection while you receive and after receiving a course of treatment. Serious infections may include:

  • listeria. People who receive LEMTRADA have an increased chance of getting a bacterial infection called listeria, which can lead to significant complications or death. Avoid foods that may be a source of listeria or make sure foods are heated well.
  • herpes viral infections. Some people taking LEMTRADA have an increased chance of getting herpes viral infections. Take medicines as prescribed by your healthcare provider to reduce your chances of getting these infections.
  • tuberculosis. Your healthcare provider should check you for tuberculosis before you receive LEMTRADA.
  • hepatitis. People who are at high risk of, or are carriers of, hepatitis B (HBV) or hepatitis C (HCV) may be at risk of irreversible liver damage.

These are not all the possible infections that could happen while on LEMTRADA. Call your healthcare provider right away if you have symptoms of a serious infection such as fever or swollen glands. Talk to your healthcare provider before you get vaccinations after receiving LEMTRADA. Certain vaccinations may increase your chances of getting infections.

Progressive multifocal leukoencephalopathy (PML): A rare brain infection that usually leads to death or severe disability has been reported with LEMTRADA. Symptoms of PML get worse over days to weeks. It is important that you call your doctor right away if you have any new or worsening medical problems that have lasted several days, including problems with:

  • thinking
  • eyesight
  • strength
  • balance
  • weakness on 1 side of your body
  • using your arms or legs

Inflammation of the gallbladder without gallstones (acalculous cholecystitis): LEMTRADA may increase your chance of getting inflammation of the gallbladder without gallstones, a serious medical condition that can be life-threatening. Call your healthcare provider right away if you have any of the following symptoms:

  • stomach pain or discomfort
  • fever
  • nausea or vomiting

Swelling of lung tissue (pneumonitis): Some people have had swelling of the lung tissue while receiving LEMTRADA. Call your healthcare provider right away if you have the following symptoms:

  • shortness of breath
  • cough
  • wheezing
  • chest pain or tightness
  • coughing up blood

Before receiving LEMTRADA, tell your healthcare provider if you:

  • have bleeding, thyroid, or kidney problems
  • have a recent history of infection
  • are taking a medicine called Campath® (alemtuzumab)
  • have received a live vaccine in the past 6 weeks before receiving LEMTRADA or plan to receive any live vaccines. Ask your healthcare provider if you are not sure if your vaccine is a live vaccine
  • are pregnant or plan to become pregnant. LEMTRADA may harm your unborn baby. You should use birth control while receiving LEMTRADA and for 4 months after your course of treatment
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you should receive LEMTRADA or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. LEMTRADA and other medicines may affect each other, causing side effects. Especially tell your healthcare provider if you take medicines that increase your chance of getting infections, including medicines used to treat cancer or to control your immune system.

The most common side effects of LEMTRADA include:

  • rash
  • headache
  • thyroid problems
  • fever
  • swelling of your nose and throat
  • nausea
  • urinary tract infection
  • feeling tired
  • trouble sleeping
  • upper respiratory infection
  • herpes viral infection
  • hives
  • itching
  • fungal infection
  • joint pain
  • pain in your arms or legs
  • back pain
  • diarrhea
  • sinus infection
  • mouth pain or sore throat
  • tingling sensation
  • dizziness
  • stomach pain
  • sudden redness in face, neck, or chest
  • vomiting

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LEMTRADA.

You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information/Medication Guide, including serious side effects, for additional Important Safety Information.

©2019 Genzyme Corporation. All rights reserved.

Source: Am I having an RMS relapse again? See some common signs.

Listen as Dr. Daniel Ontaneda, Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, reviews relapses in the MS disease course, what a relapse is, and why it is important to better understand them with one of his patients. For more information about MS relapse or other related MS questions, visit http://my.clevelandclinic.org/service….

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Sleep Deprivation Fuels Accumulation Of Two Alzheimer’s Proteins In The Brain

The brain of a sleep-deprived person is imbued with excess of two proteins that are substantially associated with Alzheimer’s disease.

According to the study published in the journal Science, a protein called tau is found in excess in the fluid that fills the brain and spinal cord of individuals with chronic sleep deprivation. The protein also drives neuron degeneration, and during Alzheimer’s, it scatters throughout the brain.

Similarly, sleep deprivation also induces accumulation of protein called amyloid-beta – a chunk of which dots the brains of Alzheimer’s patients.

In the study, researchers went over the samples of cerebrospinal fluid of eight adult participants who were sleep-deprived for nearly 36 hours. They found 51.5 percent increase in their tau levels. Similarly, mice that were rob of sleep were found to have twice the level of tau compared to well-rested ones.

Another study also reported that the lack of sleep to be the legitimate cause of increased level of A-beta in the cerebrospinal fluid, and if preceded by a week of poor sleep, the levels of tau also increased.

Since lack of sleep increases the levels of tau and A-beta in the brain, it appears that the only way to curtail the risk of developing Alzheimer’s symptom is to treat sleep disorders during mid-life and get good amount of sleep as much as possible. Proper sleep helps our brain get rid of excess proteins and other unnecessary stuffs, so getting less sleep means that wash cycle is disturbed.

References:

  • Lack of sleep is tied to increases in two Alzheimer’s proteins (Science News)
  • The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans (Science)
  • Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia (Jama Neurology)

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Source: Sleep Deprivation Fuels Accumulation Of Two Alzheimer’s Proteins In The Brain – Sparkonit

14.2K subscribers
This 4-minute video shows how Alzheimer’s disease changes the brain and looks at promising ideas to treat and prevent the disease. Alzheimer’s disease is the most basic form of dementia, and scientists are trying to understand how the affects the nervous system. This video illustrates how neurons communicate in a healthy brain compared to that of a person with Alzheimer’s disease. In a healthy brain, cells such as astrocytes and microglia help keep neurons healthy by clearing away debris that builds up over time. In a person with Alzheimer’s disease, toxic changes in the brain destroy the ability of these cells to maintain a healthy environment for the neurons in the brain, ultimately causing a loss of neurons. Researchers believe that the Alzheimer’s disease process involves two proteins: beta amyloid protein and tau protein. Within the brain of a person with Alzheimer’s disease, these proteins become compromised. Over time, abnormal tau accumulates and eventually forms tangles inside the neurons, and the beta amyloid clumps into plaques, which build up between the neurons. As the level of amyloid increases, tau rapidly spreads throughout the brain. Other changes that affect the brain may play a role in the disease, such as the inability of the vascular system to deliver enough blood and nutrients to the brain. These factors cause the brain to shrink in size, starting with the hippocampus. A person with Alzheimer’s gradually loses the ability to think, remember, make decisions, and function independently. Researchers are working on the key to understanding Alzheimer’s disease so that Alzheimer’s disease research can lead to the development of more effective therapies with the hope that we can delay or even prevent the devastation of dementia. This video was developed by the National Institute on Aging (https://www.nia.nih.gov/), part of the National Institutes of Health (https://www.nih.gov/). Want to learn more? Subscribe to the National Institute on Aging’s YouTube channel: https://www.youtube.com/user/NatlInst…. Find more information about Alzheimer’s disease from the National Institute on Aging: https://www.nia.nih.gov/health/alzhei…. Find more health information from the National

“Wakefulness” Part of the Brain Attacked First in Alzheimer’s, Study Says

Lea Grinberg, a neuropathologist and associate professor at the UCSF Memory and Aging Center in San Francisco’s Mission Bay, holds slides of brain tissue used for research on August 15, 2019. (Lindsey Moore/KQED)

People who donate their bodies to science might never have dreamed what information lies deep within their brains.

Even when that information has to do with sleep.

Scientists used to believe that people who napped a lot were at risk for developing Alzheimer’s disease. But Lea Grinberg with the UCSF Memory and Aging Center started to wonder if “risk” was too light a term — what if, instead, napping indicated an early stage of Alzheimer’s?

About a decade ago, Grinberg — a neuropathologist and associate professor — was working with her team to map a protein called tau in donated brains. Some of their data, published last week, revealed drastic differences between healthy brains and those from Alzheimer’s patients in the parts of the brain responsible for wakefulness.

Lea Grinberg uses a program that takes a microscope’s magnification of brain tissue on a slide and projects it on a computer screen on August 15, 2019. The different colors represent different biological features in the brain tissue sample, including neurons and tau protein. (Lindsey Moore/KQED)

Wakefulness centers in the brain showed the buildup of tau — a protein that clogs neurons, Grinberg says, and lets debris accumulate. Gradually, these clogged neurons die. Some areas of the diseased brains had lost as much as 75% of their neurons. That may have led to the excessive napping scientists had observed before. Although the team only studied brains from 13 Alzheimer’s patients and 7 healthy individuals, Grinberg says that the degeneration caused by Alzheimer’s was so profound they were sure of its significance.

“We are kind of changing our understanding of what Alzheimer’s disease is,” she says. “It’s not only a memory problem, but it’s a problem in the brain that causes many other symptoms.”

Although these symptoms aren’t as severe as complete loss of memory or motor functions, Grinberg says they can still hold real consequences for a person’s quality of life. “Because if you don’t sleep well every day and if you… are not in the mood to do things like you were before, it’s very disappointing, right? My grandparents were like this.”

Grinberg says it’s important to know whether napping could be an early sign of Alzheimer’s, for treating symptoms and developing drugs that could slow the progression of the disease. Although there are no prescription drugs available to treat tau buildup, she says, a few are in clinical trials.

Lea Grinberg holds boxes filled with samples of brain tissue for study on August 15, 2019. (Lindsey Moore/KQED)

A public health professor and neuroscientist at UC Berkeley says the new information offers hope to researchers. William Jagust, who has studied Alzheimer’s for over 30 years, says the results could help select patients for clinical trials of new drugs that require early treatment. “It’s also just very important for understanding the evolution of Alzheimer’s disease with the hope that we eventually will have a drug,” he adds.

It’ll be awhile before doctors can diagnose anyone with Alzheimer’s based on how often they doze off. “There’s no practical application of this to clinical medicine as of today,” Jagust says, “but I think it’s on the cutting edge of the very, very important questions.”

By:

Source: “Wakefulness” Part of the Brain Attacked First in Alzheimer’s, Study Says

What is Alzheimer’s disease? Alzeimer’s (Alzheimer) disease is a neurodegenerative disease that leads to symptoms of dementia. Progression of Alzheimer’s disease is thought to involve an accumulation of beta-amyloid plaque and neurofibrillary tangles in the brain. Find more videos at http://osms.it/more. Study better with Osmosis Prime. Retain more of what you’re learning, gain a deeper understanding of key concepts, and feel more prepared for your courses and exams. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways and more when you follow us on social: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Osmosis’s Vision: Empowering the world’s caregivers with the best learning experience possible.

Reversing the Damage of a Stroke

For one patient, a decade of recovery took determination, persistence and the courage to weather repeated setbacks.

Strange as it may seem, the stroke Ted Baxter suffered in 2005 at age 41, leaving him speechless and paralyzed on his right side, was a blessing in more ways than one. Had the clot, which started in his leg, lodged in his lungs instead of his brain, the doctors told him he would have died from a pulmonary embolism.

And as difficult as it was for him to leave his high-powered professional life behind and replace it with a decade of painstaking recovery, the stroke gave his life a whole new and, in many ways, more rewarding purpose.

Before the stroke, Mr. Baxter’s intense work-focused life as a globe-trotting executive in international finance had eroded his marriage and deprived him of fulfilling relationships with family and friends. Unable to relax even on vacation, he rarely took time to smell the roses. Now, he told me, he leads a richer, calmer, happier life as a volunteer educator for stroke victims and their caregivers and for the therapists who treat them.

The stroke began with a cramping pain in his leg after a long international flight during which he wore compression hose to support his varicose veins. He didn’t take the pain seriously until suddenly he couldn’t talk or move the right side of his body. The clot that caused his leg pain had broken loose and cut off blood flow to the left side of his brain.

He nearly died. But once stabilized, the doctors discovered that he was born with a hole in his heart that had allowed the clot to bypass his lungs and go directly to his brain. Two of his siblings turned out to have the same defect, called patent foramen ovale, which they subsequently had repaired.

Mr. Baxter readily admits that his Type A personality, which was the driving force behind his professional success, was also a major factor that helped him reverse the extensive losses he suffered when the clot severely damaged his brain. And it inspired him to recount his 14 years of recovery and renewal in a fascinating book, “Relentless: How a Massive Stroke Changed My Life for the Better,” an apt title for what it took for him to regain full physical function, comprehension and intelligible speech.

His mantra, which could help many others facing a devastating health setback, is that recovery takes determination, focus, resiliency, persistence and courage — the courage to weather repeated setbacks and frustrations. He admits, however, that it can also take the financial resources and personal support he had to get the kind of help that can make a difference.

At first, his goal was to get right back in the saddle, working nonstop in finance. But after months of intense rehab, he still could neither use nor understand language, spoken or otherwise.

“It took seven or eight months for me to realize I wasn’t going back to my job,” he said. “I didn’t even understand that the words coming from my mouth weren’t making any sense.”

The learning curve was steep: “I couldn’t read; I couldn’t write. I could see the hospital signs, the elevator signs, the therapists’ cards, but I couldn’t understand them,” he wrote. The aphasia — the inability to understand or express speech — “had beaten and battered” his pride.

But he refused to give up. With age and prestroke physical conditioning on his side, he had convinced himself that “100 percent recovery was possible as long as I pushed hard enough.”

Mr. Baxter figured if he could get his body functioning again, his language facility might also return. The brain, he learned, was plastic and capable of renewal. So he devoted countless hours to physical therapy, worked out in the gym long and hard, and had his left arm tied behind his back, forcing himself to use the right. He found that as his physical abilities improved, so did his comprehension and communication skills.

When what he tried to say came out garbled, many people assumed he was either mentally slow or a foreigner with limited English. As one of his speech therapists said of people with aphasia, “It’s hard to understand that they have their intellectual faculties and know what they want to say, but they don’t have the ability to communicate it.”

Mr. Baxter researched and enrolled in several different aphasia programs throughout the country. For many hours a day, he did language practice, starting with books and flash cards for preschoolers and doing endless repetitions to relearn speech until eventually — after years of hard work — he was finally able to read books and have real conversations.

His original therapists at the Rehabilitation Institute of Chicago, admittedly amazed at the progress he made, asked what benefited him the most and solicited his help developing a new, intensive aphasia program. He was also invited to participate in Archeworks, a design program in Chicago for students working to solve urban problems.

“I faced the challenge of using my right hand, making new friends, and communicating effectively with a team,” he wrote. He was building things with his hands and tools and suddenly he realized he was problem-solving, a skill he had used often in finance.

Sports also aided his recovery. As he slowly regained use of his right side, he took lessons in golf and boxing, aided by watching others do things correctly.

“If I could see somebody do something, then I could follow it and mimic what they did,” he wrote. “I had to focus on visualization — picturing the task, the actions needed to perform that task, and the intended result.”

Art therapy was another helpful pursuit, which he said reduced his stress, countered depression and improved his self-esteem and emotional health. With art as a new source of fulfillment came an invitation to join a museum board that gave him additional conversational practice and “withered away my aphasia every day.”

Gradually, Mr. Baxter said he “started to realize that by doing more for others, I’d be happier with myself.”

Living now in Newport Beach, Calif., with his second wife, the 55-year-old stroke survivor devotes his life to inspiring other survivors and their caregivers. “I go to universities and hospitals to present my story — what I had experienced, how I rehabbed myself, how it changed my life for the better, and what it took to get my life back,” he wrote.

“Sometimes, I can’t believe how far I’ve come,” he said. He credited family members and friends who “never gave up on my recovery, nor did they ever treat me as if I were lost, and because of that, I never felt lost. None of it would have worked without a positive attitude.”

 

 

Source: Reversing the Damage of a Stroke

Stress Changes The Brain, And This Could Be How It Happens

The results of a new brain imaging study may have just answered a big question about how stress changes the brain. Using a combination of genetic editing and brain scanning in mice, researchers found that stress triggers a chemical cascade that radically changes how brain networks communicate, and the results could sharpen our understanding of anxiety disorders in humans.

Breaking down the research

Stress serves an important purpose in preparing us to react to danger. Anything the brain perceives as threatening triggers multiple brain networks to synchronize and communicate, all in just a fraction of a second. With systems humming, we make immediate decisions to survive the threat.

But what facilitates all of those brain networks to connect and communicate? That’s been a difficult question to answer in the human brain, because doing so would require examining brain function during the split-second window of facing a threat.

Enter our friends the mice to help solve the problem. Researchers followed a trail of previous studies and zeroed in on the neurotransmitter noradrenaline (aka norepinephrine, a chemical that floods the brain during stress) as a likely facilitator of brain-network connectivity.

The twist was that they had genetically manipulated the rodents’ brains to allow for selectively controlling when noradrenaline was released (not possible in human brains). While controlling the chemical faucet, they also scanned the mouse brains using fMRI to see what would happen.

And what happened, it turns out, was pretty amazing. The release of noradrenaline “rewired” the mouse brains, allowing different brain networks to instantly cross-communicate. But the neurotransmitter wasn’t just facilitating communication, it was restructuring neural connections beyond anyone’s expectations.

“I couldn’t believe that we were seeing such strong effects,” said the study’s first author Valerio Zerbi, a brain imaging specialist from the University of Zurich.

The researchers found the strongest rewired effects in brain areas responsible for processing sensory stimuli (auditory and visual, for example), and in the amygdala, the epicenter of the brain’s threat response system.

What does this mean for us?

It’s the part about threat response that may hold the most promise for better understanding what stress does to our brains.

Allowing for the fact that this was research in mice, the particular dynamic studied here is probably quite similar between us and our rodent counterparts. If noradrenaline rewires the human brain as it appears to rewire the brains of mice, it’s possible the long-term effects of stress are more profound than we’ve realized.

Previous research has linked the flood of noradrenaline to changes in brain connectivity, but it seems likely we’ve underestimated the effects, especially in the small but powerful part of our brain sitting at the center of anxiety disorders: the amygdala.

At a minimum, this research opens new doors for better understanding how both acute and chronic stress effects the brain, and could enlighten new ways of deconstructing anxiety conditions, now the most prevalent mental health disorders worldwide. The study was published in the journal Neuron.

Follow me on Twitter. Check out my website or some of my other work here.

David DiSalvo is the author of the best-selling book “What Makes Your Brain Happy and Why You Should Do the Opposite”, which has been published in 15 languages, and the books “Brain Changer: How Harnessing Your Brain’s Power to Adapt Can Change Your Life” and “The Brain in Your Kitchen”. His work has appeared in Scientific American Mind, Forbes, Time, Psychology Today, The Wall Street Journal, Slate, Esquire, Mental Floss and other publications, and he’s the writer behind the widely read science and technology blogs “Neuropsyched” at Forbes and “Neuronarrative” at Psychology Today. He can be found on Twitter @neuronarrative and at his website, daviddisalvo.org. Contact him at: disalvowrites [at] gmail.com.

Source: Stress Changes The Brain, And This Could Be How It Happens

How To Train Your Brain To Go Positive Instead Of Negative – Loretta Breuning

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Our brain is not designed to create happiness, as much as we wish it were so. Our brain evolved to promote survival. It saves the happy chemicals (dopamine, serotonin and oxytocin) for opportunities to meet a survival need, and only releases them in short spurts which are quickly metabolized. This motivates us to keep taking steps that stimulate our happy chemicals. You can end up with a lot of unhappy chemicals in your quest to stimulate the happy ones, especially near the end of a stressful workday……..

Read more: https://www.forbes.com/sites/womensmedia/2016/12/21/how-to-train-your-brain-to-go-positive-instead-of-negative/#707a40525a58

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

George Gilder- Life After Google Blockstack Berlin 2018

George Franklin Gilder is an American investor, writer, economist, techno-utopian advocate, and co-founder of the Discovery Institute. His 1981 international bestseller Wealth and Poverty advanced a practical and moral case for supply-side economics and capitalism during the early months of the Reagan administration and made him Ronald Reagan‘s most quoted living author.[2] Married to Nini Gilder, he has four children.

In the 1970s, Gilder established himself as a critic of feminism and government welfare policies, arguing that they eroded the “sexual constitution” that civilized and socialized men in the roles of fathers and providers. In the 1990s, he became an enthusiastic evangelist of technology and the Internet by several books and his newsletter, the Gilder Technology Report. He is also known as the chairman of George Gilder Fund Management, LLC…….

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

 

How To Succeed Without Data, In A Data Driven World – Chaka Booker

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There are some words that inspire confidence when you use them. “Data” is one of those words. Throw “data-driven” in front of “decision-making” and you’ll suddenly find yourself more credible. If someone is sharing an idea, ask about “the data” and your IQ shoots up several points. I believe in data. I understand how data can identify trends, minimize risk and lead to better decisions. Data comforts me. But the fixation on data has a drawback. It leads to the belief that decisions made without data – aren’t as strong. Never mind that bad decisions, based on data, get made all the time……

Read more: https://www.forbes.com/sites/chakabooker/2018/10/06/how-to-make-decisions-without-data-in-a-data-driven-world/#5ba0f01e1d6e

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

7 Riddles That Will Test Your Brain Power – Bright Side

These 7 puzzles will trick your brain.  Take this fun test to check the sharpness and productivity of your brain. Try to answer these questions as quickly as possible and see the results!  Our brain is a mysterious thing. We know more about stars than about the things inside our heads! But what we do know about the brain is that it gets less sharp and productive with age.

You have a maximum of 20 seconds for each task, but try to answer the questions as fast as possible. TIMESTAMPS What is the mistake two photos have in common? 0:45 How many holes does the T-shirt have? 1:53 How would you name this tree? 2:40 Can you solve this riddle one in 5 seconds? 3:21 Do you see a hidden baby? 4:26 Which line is longer? 5:12 Can you spot Mike Wazowski? 6:30 SUMMARY If it took you more than 20 seconds to answer each question, or you didn’t manage all the tasks, it means that you have the brain of a mature person.

It ‘s hard for you to make your mind see beyond the obvious and you can’t handle change easily. If took you less than 20 seconds, your brain is quite young, and you can approach tasks from different angles. If you answered each question correctly in less than 5 seconds, your brain is very young and flexible! You can notice the tiniest details right away and adapt to new situations easily! What is your result? Tell us in the comment section below!

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New Font Sans Forgetica Designed to Boost Your Memory – Jackson Ryan

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Researchers at the Royal Melbourne Institute of Technology (RMIT) in Australia have developed an entirely new font designed “using the principles of cognitive psychology” to help you better remember your study notes. The font is a sans serif style typeface, with two unusual features: It slants slightly left, which is a rarely used design principle in typography, and it’s full of holes. Those holes have a purpose though. They make Sans Forgetica harder to read, tricking your brain into using “deeper cognitive processing” and promoting better memory retention…….

Read more: https://www.cnet.com/news/new-font-sans-forgetica-is-designed-to-boost-your-memory/

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

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