Category: Drugs

How Serial Entrepreneur Keith McCarty Is Building Tech Solutions For The Cannabis Industry

Keith McCarty was two years into his Snoop Dogg-backed cannabis startup when he knew it was time for a change. Eaze, nicknamed the Uber for Weed as it serves as a delivery platform connecting cannabis dispensaries and their customers in legalized areas, was hitting its stride. It was 2014, and the company was on the eve of closing on a $40 million Series B round. What’s more, Eaze’s home state of California had just voted to legalize recreational use of marijuana, serendipitously expanding the company’s services beyond medical use clientele. But connecting clients and dispensaries came with multiplying constraints of the scattered commercial supply chain. So for McCarty, it was time to go.

McCarty, a serial entrepreneur, a founding team member of social media startup Yammer, saw an opportunity in the excruciating pain points between cannabis brands and dispensaries. In August, three years after his departure from Eaze and with $5 million in seed funding, McCarty launched Wayv, a B2B version of Eaze.“With more legalization comes more regulation and causes more friction in the supply chain,” McCarty told Forbes. That’s why he’s doubling down on his bet that tech solutions will help smooth out the logistical kinks through Wayv’s Amazon fulfillment model, in which brands can list their products and retailers can place bulk orders for next day delivery.

Like soda or cigarettes, the cannabis business is emerging with multiple brands, and each has its fans. It’s in the interest of every dispensary to carry the brands its customers prefer, but because of byzantine and contradictory state and federal laws, outlets can’t order multiple brands from a single outlet. Adding to the complication is the fact that nobody in the supply chain, not the growers, processors, distributors or retailers, can use banks to make it all happen as facilitating the sale of cannabis is against federal law.

Each cannabis brand begins with growers, processors and state-mandated laboratory tests before it hits the distributor, which gets the brand product to the warehouse before it’s ready to hit dispensary shelves. Together, cannabis brands bear the operational brunt of marketing, sales and processing transactions, and retailers can’t buy brands in bulk but have to deal with each individually.

“Today, the process retailers have to go through is sending emails, text messages and make calls to 30 to 50 brands to even place the order,” McCarty said. “This is one of the biggest white spaces in the industry and one of the most unsolved aspects.” In California, Wayv is greasing the cannabis distribution track, offering a “seed to sale” e-commerce compliance and distribution platform. For 80% of California’s licensed retailers using Wayv’s services, access to live inventory and brands beyond their geographical market means consistent and diverse product selection for dispensary customers. For a 15% fee, Wayv replaces the door-to-door salesman model for brands to get their products on store shelves and offloads the delivery and payment exchange—which is mainly cash-based.

Beboe, a high-end vape and edibles company, uses Wayv as a marketing tool and credits the platform for an uptick in sales. “Last year there was such a supply and demand issue because there was no data before,” said Kiana Anvaripour, Beboe’s VP of marketing. “Wayv has helped us be nimble and quick—it’s a way for you to be able to show your brand digitally.”

Brands, retailers and the distributor can all track the status of the order through Wayv’s platform and app, which helps avoid unwanted issues such as ordering the wrong product or amount—cannabis products legally come with a nonreturnable policy upon delivery.

Wayv also addresses one of the biggest pain points for brands, the inability to access  traditional lines of credit. To alleviate the cash flow part of the supply chain, Wayv offers an initial credit line and takes on delinquency and default for brands to help them keep up with market demand. “We understand that brands don’t want to be a distributor or tech company. Both of those are provided for a 15% fee, and that’s lower than your fully weighted distribution cost,” McCarty said.

McCarty remains the majority shareholder of Eaze, which he launched with his Yammer cofounders, Jim Patterson, Aleksey Klempner and Roie Edery. He spent a year at Microsoft after it purchased Yammer for $1.2 billion in 2012 before moving into cannabis. As research, McCarty interviewed 150 medical marijuana patients at the San Francisco medical dispensary Sparc. The biggest problem with the plant, McCarty cleared, was lack of easy access. Hence, Eaze.

“Eaze was pushing the limits of what’s required by brands to be able to participate, and very quickly you start to realize there’s a supply constraint about to happen,” said McCarty. He reemerged on the cannatech scene last summer with the launch of Wayv and $5 million in seed funding from Yammer cofounder David Sacks, his first investment in a cannabis business.

While there are a handful of cannabis POS startups, one thing Wayv has over one of its competitors is partnerships with a licensed distributor and lab. McCarty says one of the biggest hurdles brands face is getting their product into the dispensaries. The average mom-and-pop brownie business doesn’t have the funds to hire a delivery driver, so Wayv deploys a third-party distributor, Indus, to fulfill pickups for brands and drop-offs for retailers. Wayv also offers the option to offload state-mandated testing requirements by partnering with a licensed lab that conducts product batch testing adjacent to Indus’ warehouse.

Because Wayv is not vertically integrated, it’ll be easy to expand outside of California, but McCarty cautions that scaling is a race against time. “This is a very complex part of the supply chain,” he says. “People could probably do it over time, but the industry doesn’t have time.”

Follow Samar on Twitter at @HellaSamar or email her at smarwan[at]forbes.com.

Samar Marwan is the West Coast-based assistant editor of technology at Forbes. Marwan’s coverage of women run startups and the MENA tech scene has gone into defining

Source: How Serial Entrepreneur Keith McCarty Is Building Tech Solutions For The Cannabis Industry

Advertisements

Cannabis Companies Struggle To Become More Sustainable

Despite the bad press millennials receive, as a cohort they have committed to sustainability. A full 70% of millennials will pay more for products made sustainably, while 83% consider a product’s environmental or social impact before making a purchase. They are bringing that sense of responsibility for maintaining a livable planet to the cannabis industry which is populated with young, progressive entrepreneurs. But while cannabis is a business based around agriculture, there aren’t clear rules for how to make it more sustainable…..

Source: Cannabis Companies Struggle To Become More Sustainable

The Global Drug Industry Putting Your Life At Risk – Srinath Perur

1.jpg

In late 2012, 60 people died in two cities in Pakistan after drinking cough syrup to get high. Syrups from two separate manufacturers were involved. It was found that both were using an active ingredient — dextromethorphan, a synthetic morphine-like compound — imported from the same manufacturer in India. Indian drug authorities put a halt to production while they investigated. Tests in Pakistan revealed that the medicines seemed to contain the correct amount of active ingredient. But further tests revealed something that was not supposed to be there……..

Read more: http://digg.com/2018/fake-drugs-global-industry

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

 

Are Supplements Safe & Do They Work – Dr Carter

1.jpg

The story of a man who ended up needing a liver transplant after taking green tea capsules has brought the topic of dietary supplements back into the news. What are some of the dangers of supplements and what are the health benefits? When Jim McCants started taking green tea pills he had hoped he was giving his health a shot in the arm. Instead, it appears the pills caused such serious damage to his liver that it required an urgent transplant……..

Read more: https://www.bbc.com/news/health-45992725

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

Marijuana Madness: This Is How CBD Oil Can Cause A Failed Drug Test – Mike Adams

1.jpg

Cannabidiol, otherwise referred to as CBD is considered by a growing number of Americans to be the best thing since sliced bread. Not only does this non-intoxicating component of the cannabis plant provide people with relief from conditions ranging from anxiety to chronic pain, but it’s also mostly overlooked by law enforcement, in spite of its outlaw status in the eyes of the federal government. But people are being told that they can consume CBD on a daily basis and never have to worry about failing a drug test……

Read more: https://www.forbes.com/sites/mikeadams/2018/10/18/marijuana-madness-this-is-how-cbd-oil-can-cause-a-failed-drug-test/#1f76c92713bb

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

Antibiotic Resistance: Breakthrough Study Offers Solution – Catharine Paddock PhD

1.jpg

When a team at Case Western Reserve University School of Medicine in Cleveland, OH, treated mice with specific small molecules that stop bacteria from producing toxins, all the animals survived an MRSA sepsis infection, compared with less than a third of untreated mice. The finding is significant because if the same is true of humans, then it shows that it may not be necessary to use antibiotics to cure sepsis……

Read more: https://www.medicalnewstoday.com/articles/323388.php

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

FDA Expands Recall Of Blood Pressure Drug Valsartan Due To Cancer Concern — CBS Atlanta

Valsartan recall: 4 things patients should know By Jacqueline Howard, CNN (CNN) — Several common drugs that contain valsartan, used to treat high blood pressure and heart failure, have been recalled in the United States due to an “impurity” in the drug that poses a potential cancer risk. That impurity, N-nitrosodimethylamine or NDMA, is classified…

via FDA Expands Recall Of Blood Pressure Drug Valsartan Due To Cancer Concern — CBS Atlanta

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you
https://www.paypal.me/ahamidian

 

No Scientific Evidence That Probiotics Improve Anxiety Symptoms In Humans, Finds Study – David DiSalvo

2.jpg

A new review and analysis of several studies has found that probiotics do not improve self-reported anxiety symptoms in humans, although there was evidence of minor improvements in rodents.

The study reviewed 36 preclinical studies in total, 14 involving humans and 22 involving rats and mice. That’s a decent-sized sampling of the research covering a variety of probiotic strains, and it turned up zero evidence that humans with self-reported anxiety symptoms benefited from taking any of them.

“Probiotics did not significantly reduce symptoms of anxiety in humans and did not differentially affect clinical and healthy human samples,” the study concluded.

One of the strains, Lactobacillus (L.) rhamnosus, did appear to reduce anxiety symptoms in rodents, but further analysis showed that effects were most pronounced only for the sickest of the specimens, and even in those animals the results weren’t dramatic.

Probiotics are one of the strongest selling nutritional products in the world, with annual US sales exceeding $3.3 billion in 2016. That market size is predicted to more than double by 2025. Clearly a large chunk of the supplement-buying public has confidence in these products, and the marketing push is only intensifying. But this study, like others turning up similar findings, suggests caution is warranted.

“I think people should wait — that’s the best takeaway here,” said lead study author Daniel J. Reis, a doctoral student of clinical psychology at the University of Kansas. “We’re in the early days of this research into probiotics. I’ve seen a lot of stories hyping probiotics as helpful for anxiety. We’re not saying they do nothing, but we have a lot to figure out before we know if they can be used therapeutically.”

Why some effects were found in rodents and not in humans isn’t clear, but the researchers noted that the differences in dosage between humans and rodents were significant.

“If you control for the weights of animals versus humans, animals are getting much larger doses of probiotics in these experiments by one or two orders of magnitude. Sometimes the doses were hundreds of times higher than we see in human studies,” said Reis in a press statment.

The researchers also noted that while this study didn’t find anxiety-reducing benefits for humans, it’s still possible that a pathway exists for certain strains to yield therapeutic effects. And they were clear that the anxiety levels among the human participants in the reviewed studies weren’t necessarily “clinically elevated.” Future research has an opportunity to delve more deeply among that expanding population.

“We see a lot of pathways between our digestive systems and our brains,” Reis said. “We see nervous system connections, the inflammation response — these microorganisms seem to be able to influence the human brain through this gut-brain axis. We wanted to know if changes to the microbiota could improve mental health. But in terms of research, it’s all at a very preliminary stage.”

And that, for the moment, is the big takeaway on probiotics – the research is still very preliminary, despite marketing claims of conclusive results. Evidence supporting the claims just isn’t there, at least not yet.

Scientific research is nearing a consensus that bacteria in our digestive systems affect our brains. The microbiome in our guts, populated by billions of bacteria, appears to play a significant role not only in our digestive health, but also our mental health. Exactly how this happens is still being worked out, with each new study turning over another proverbial rock of possibilities. Despite these advances, we don’t yet know how, or if, probiotic supplements can improve our mental health by influencing gut bacteria. The marketing of these products is far ahead of the facts, as a quick review of what we know will show.

First, a brief sampling of the latest bacteria-brain research, which includes a study that found specific hormonal exchanges enabling communication between gut bacteria and the brain. This is especially noteworthy because the hormone in question is cortisol, the so-called “stress hormone”– a well-established indicator of stress levels in humans and other mammals. The study was conducted in pigs, which share several physiological similarities with humans, and it identified a possible communication pathway between gut bacteria and the brain that uses cortisol as a channel to send “messages.” The implications of this research will take some time to unravel, but one initial takeaway is that our stress-response system may play a key role in how gut bacteria communicate with the brain.

1.jpg

Another recent study suggests that gut bacteria may influence anxiety and depression. This study was conducted with mice raised in a sterile, germ-free environment devoid of bacterial influence. Researchers exposed these mice to gut bacteria and watched what happened compared to mice that were raised in a normal, germy environment.  The germ-free mice exposed to bacteria developed anxiety and depression symptoms on par with the human equivalent. The researchers identified a specific brain region influenced by the bacteria, and suspect that our early-life exposure to bacteria may predispose us one way or another to anxiety and depression later on. Again, the conclusions are speculative, but the research is exciting because it moves us a little closer to figuring out what’s going on.

More studies like these are underway and another wave is in the planning phase. So why, with all of this research, can’t we make grand claims for the promise of probiotics? After all, if we have even an inkling that gut bacteria affect our brains (and we certainly have more than an inkling at this point) then why not jump onboard the probiotic supplement express?

The reasons can be boiled down to a few big ones.

The probiotic philosophy is to blast the gut with billions of allegedly “good” bacteria, in hopes of populating out the bad ones. While re-populating the gut with good bacteria sounds plausible, there’s little scientific clarity around which gut bacteria are objectively “good” or if that qualification is even valid. Bacteria can be “good” or “bad” depending on a slew of variables. Even less clear is which bacteria influence the brain and how they’re exerting their influence.

But let’s say we could achieve perfect clarity on that point, there’s still an enormous gastric obstacle ahead. Whether you’re ingesting a probiotic with one billion or 30 billion live bacterial cultures, they still have to survive your stomach acid to do anything worthwhile. Only a couple types of bacteria have proven resistant enough to survive that peril (lactobacillus and bifidobacteria), which means almost everything else in your pricey probiotic capsule is toast.

But let’s say that problem is solved by a fantastic pill coating – what will this army of bacteria do once they arrive in your gut?  We simply don’t know enough to know for sure. Last year a review of probiotic trials in humans concluded that the research “demonstrates a lack of evidence for an impact of probiotics on fecal microbiota composition in healthy adults.” In other words, we don’t know precisely what probiotics are doing in the gut – and there’s at least a possibility that they aren’t doing much to make a difference.

Given how little we understand about what probiotics can accomplish in our guts, jumping to a further conclusion that they can improve our mental health is really reaching. That hasn’t stopped those marketing these products from making outlandish claims, but that’s standard operating procedure for a large chunk of supplement marketing.

Where actual science is concerned, we don’t yet know if probiotics can achieve the promises made for them, or what sort of probiotic formula will prove effective. We may eventually find out that probiotics need to be tailored to a given person’s microbiome like bespoke clothing. Once that’s established (if it can be established), then perhaps we’ll have a better opportunity to understand how probiotics might improve our mental health – assuming the underlying theory holds up over time.

Right now, we don’t know enough to justify the claims made for probiotic supplements. The marketing is leagues ahead of the evidence, and we’d do well to view these claims with skepticism. Perhaps one day probiotics will give our brains a boost, but we’re just not there yet.

If everyone who reads our articles and like it , that would be favorable if you send us your donations…THANK YOU

Should Healthy People Take Probiotic Supplements – Koldunov Alexey

3.jpg

A visit to the supermarket these days can feel more like walking through a pharmacy, with an ever-expanding range of milks, yoghurts, pills, powders and speciality foods promoting their “probiotic” prowess.

Advocates of probiotics have hailed them as the answer to all sorts of health issues and conditions. But what exactly are probiotics? And, more importantly, should you be taking them?

Probiotics are scientifically defined as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”. In simple terms, they’re “good” bacteria that are beneficial to the body.

Probiotics exist naturally in some foods (such as some types of yoghurt and fermented vegetables such as pickles and sauerkraut), but can also be taken in dietary supplement form, via products such as Yakult and Inner Health Plus.

While our digestive system ordinarily contains trillions of microbes, including both “good” and “bad” bacteria, sometimes the balance between these can get out of whack. Diseases, poor lifestyle behaviours (such as not eating enough fruit and vegetables, heavy drinking, smoking, and physical inactivity) and ageing can all disrupt this balance.

By many accounts, probiotics can improve the number and diversity of “good” gut bacteria that help to keep our digestive system healthy and working efficiently. As such, probiotics have been proposed to:

However, most scientific research on the health benefits of probiotic supplementation seems to have been done in people with existing health problems. Evidence supporting the health benefits of probiotics in healthy adults is very limited. Probiotic supplements are most likely to be consumed by the general (and otherwise healthy) population, despite this group receiving relatively little documented benefit.

We reviewed the scientific literature (45 original studies) on probiotic supplementation in healthy adults. Our findings, published in the European Journal of Clinical Nutrition, found that giving healthy adults live bacteria (either in yoghurt, capsules, or drinks) can have a few benefits:

1) it can increase the concentration of “good” bacteria. So, if an imbalance of digestive system bacteria does occur in healthy adults (due to poor lifestyle, the use of antibiotics, or ageing), probiotic supplementation may help restore the balance

2) it can reduce abdominal discomfort caused by irregular bowel movements and constipation

3) it can increase the population of “good” bacteria in and around the vagina. From the four studies conducted in this area, all four demonstrate improvements in vaginal lactobacilli after probiotic capsules or suppositories were used. This may help prevent urinary tract infection and bacterial vaginosis

4) there is some evidence that it can boost the immune system, and help reduce the incidence, duration and severity of the common cold. While the exact mechanism for this is not clear, probiotics might influence immune responses by stimulating production and improving activity of cells that fight respiratory infections. But only three studies have shown these benefits in healthy adults.

While this sounds like great news for probiotics, let’s not get carried away. Our review also found the changes appear to be short-lived. In other words, you need to keep taking the probiotic supplements for the effects to last. If you stop taking them, your gut bacteria are likely return to their pre-supplementation condition within one to three weeks.

You may be able to get longer-lasting changes by “feeding the healthy bacteria”. Like all living organisms, bacteria need food to survive. Foods that are high in dietary fibre, such as fruit and vegetables, can be used as energy sources (or so called “prebiotics”) for these bacteria.

1.jpg

We also found little evidence that probiotic supplements can reduce cholesterol in healthy adults. And there is little evidence to show that probiotics can improve glucose (blood sugar) and insulin responses in healthy adults. Taking probiotics won’t reduce heart disease risk, or prevent you from developing type 2 diabetes.

So if you have a poor diet (you eat too much take-away food and not enough fruit, vegetables and whole-grain products, or you drink alcohol too much and too often) and don’t exercise regularly, your digestive bacteria may benefit from probiotic supplements, though you’ll have to keep taking them to get lasting effects.

But if you are otherwise healthy, probiotic supplements are likely to be a waste of money. Here’s some simple advice: take what you spend on probiotic supplements, and use it to buy and eat more fruit and vegetables.

If everyone who read the articles and like it, that would be favorable to have your donations – Thank you.

Zolpidem For Sleep Deprivation Treatment

Ambien, otherwise called Zolpidem/ Zolpidem tartrate, is a narcotic generally given as a treatment for sleep deprivation. Individuals who experience the ill effects of a sleeping disorder ordinarily have resting issues that keep them alert throughout the night. A trusted medication that will successfully treat a sleeping disorder incidentally. Ambien, otherwise called Zolpidem/Zolpidem tartrate, is a […]

via Buy ambien 10mg for sale 2018 — Agora-pharmacy.com