Affordable Steroids Could Reduce Some COVID-19 Deaths by One-Third, Says World Health Organization

You’d think a robust immune system would be an awfully good thing to have if you’re battling COVID-19—and much of the time it is. But in the most extreme cases—the ones the World Health Organization (WHO) labels as “severe and critical,” denoting the most extremely ill, typically hospitalized patients, with the highest risk of death—the system meant to protect the body from disease can make things worse, leading to inflammation and other damage to the lungs, which in turn can result in an often fatal case of acute respiratory distress syndrome (ARDS).

In June, a single large study of more than 6,200 patients found that corticosteroids, a class of drugs that reduce inflammation, could prevent at least some cases of coronavirus-related ARDS and the resulting deaths. Today, the WHO confirmed that preliminary report, announcing a new policy, based on a study published in JAMA, calling for the administration of steroids to all patients in the “severe and critical” category, based on findings that the treatment could reduce mortality by slightly more than one third.

The new conclusions were reached through a meta-analysis of seven different studies, each exploring the efficacy of corticosteroids in the most serious cases of COVID-19. The combined sample group from all seven studies included 1,703 severely ill patients, 678 of whom were administered steroids and 1,025 who received ordinary care (which did not include steroids) or a placebo. All of the patients were hospitalized and most were on ventilators. Over the course of 28 days, the death rate was 34% lower among the steroid-treated patients than among those in the control group.

“The consistent findings of benefit in these studies provide definitive data that corticosteroids should be first-line treatment for critically ill patients with COVID-19,” wrote Dr. Hallie Prescott, professor of medicine at the University of Michigan, and Dr. Todd Rice, professor of Medicine at Vanderbilt University, in a JAMA editorial that accompanied the publication of the study.

Inside Barcelona’s Unfinished Masterpiece

The findings come with limitations. Steroids should not be used prophylactically in people with less serious cases of COVID-19, since the very suppression of immune system action that helps prevent or treat ARDS would only worsen the condition of people whose immune systems are functioning as they should, battling the virus without damaging the lungs. WHO also warned against “indiscriminate use” of any anti-COVID-19 therapeutic, including steroids, for fear of creating global shortages.

One new therapy that is 34% effective against one subset of cases of a disease that has sickened nearly 26 million people worldwide is not yet the stuff of victory parades. But in the grinding war against COVID-19, it is an undeniable victory in one important battle.

By Jeffrey Kluger

Dr. Steven O’Day talks about treating COVID-19 with the steroid Dexamethasone. As seen on the NBC4 News at 4 p.m. on Tuesday, June 16, 2020. ——— Don’t miss an NBCLA video, subscribe here: https://bit.ly/2NnofFF For more, visit NBCLA.COM here: https://bit.ly/2uB6niE On Facebook: https://bit.ly/2uFU1px On Twitter: https://bit.ly/2JsBm5Y About NBCLA The West Coast flagship station of the NBCUniversal Owned Television Stations, serving the vast region since 1949. NBC4 produces 43 hours each week of local news and weather, and the station features the largest award-winning investigative unit in Southern California. NBC4’s news operation has received nearly every industry award bestowed on local news, including numerous Los Angeles Emmy and Golden Mike Awards, two national and two regional Edward R. Murrow Awards, and a Peabody Award. NBC4 news is delivered across the main broadcast on channel4, at http://www.nbcla.com, and through multiple interactive social media platforms 24/7. The NBC Owned Television Stations, a division of NBCUniversal, also operates COZI TV (www.cozitv.com), a national network that brings viewers some of America’s most beloved and iconic television shows and movies. #NBC#NBCLA

Nestlé Health Science Acquires Vital Proteins

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Nestlé Health Science (NHSc), a global leader in the field of nutritional science, has agreed to acquire a majority stake in Vital Proteins, America’s top-selling collagen brand. This is the first major acquisition of a collagen-based wellness company to date. Vital Proteins was founded in 2013 by Kurt Seidensticker based on the belief that whole-food-based collagen nutrition is fundamental to maintaining overall health and longevity. Since launching, Vital Proteins has become the leading collagen brand in America, growing their annual sales above $100 million within the span of four years. The company’s brand’s portfolio includes over 150 collagen-based supplements, vitamins and food and beverage products.

Vital Proteins will continue to operate as a standalone business, “remaining committed to its founding mission of helping people live healthier lives through high quality, sustainably-sourced collagen nutrition,” according to a company statement. Seidensticker said that becoming a part of the NHSc portfolio will equip Vital Proteins with a variety of resources to scale the company’s reach and innovation. “I spent a lot of time having conversations with people I respected in the CPG space, in addition to leadership from companies that could eventually be a future partner. Through those conversations it became clear that NHSc was really aligned with our brand values, our mission and purpose to empower healthier lives,” he said.

“I’ve always envisioned Nestlé as the ideal partner and have enjoyed getting to know their team, their vision and their values. I also spent time talking to the founders of another like-minded wellness company whom I respect, to see who they thought was a good fit for their organization, and they felt Nestlé was the ideal partner as well. With Nestlé’s support, we will be able to leverage new resources, scale and capabilities, moving towards a future with an expanded global offering of high-quality nutrition products. The possibilities with Nestlé have reignited my imagination of all that Vital can be.”

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Vital Proteins complements NHSc’s other vitamin, mineral, supplement and wellness brands, including Atrium Innovations, Garden of Life, Pure Encapsulations and Persona. “This is an exciting opportunity for Nestlé Health Science to enter a growing area of nutrition with a successful brand,” said Greg Behar, CEO of NHSc. “The collagen nutrition market is growing, and Vital Proteins has shown its strength by becoming a full lifestyle brand which will perfectly complement our other vitamin, mineral and supplement brands.”

Board member and investor Brett Thomas, cofounder and managing partner of CAVU Venture Partners, credits much of the company’s success to Seidensticker’s leadership. “Kurt was a visionary founder who set out not only to create a category but to define a lifestyle—and we were believers,” said Thomas. “It was this passion, paired with his exceptional leadership skills and clear ability to execute that ultimately drove the brand’s success.” Seidensticker will remain in his role as Vital Proteins CEO, based out of the company’s headquarters in Chicago, IL.

“It speaks volumes about Vital Proteins as a wellness platform and moreover Kurt as a leader that such a great strategic partnership was formed amidst all the uncertainty in the world,” added Thomas. Since the outbreak of the pandemic, Vital Proteins has seen a more than 50% increase in demand for their products. “Consumers are now even more focused on their health and well-being in the midst of this pandemic. The appetite for authentic wellness brands that are rooted in science should remain high, particularly ones which know how to effectively communicate with Millennials and Gen-Z,” explained Romitha Mally, Vice Chairman at UBS who helped orchestrate this deal, as well as Dollar Shave Club and Sundial Brands/SheaMoisture’s sales to Unilever, Bai’s sale to Dr. Pepper Snapple Group and Primal Kitchen’s acquisition by Kraft Heinz.

To support the growth of the business, Nestlé plans to explore geographic and product expansion while maintaining the elements of the Vital Proteins brand that make it popular among consumers. Vital Proteins’ 150 unique products (representing a total of 250 variants of those products) are sold across 35,000 retail doors in North America and Europe, including Whole Foods, Costco, Target, Walgreens and Kroger.

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Source: http://www.forbes.com

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8 Signs & Symptoms of Vitamin D Deficiency

Vitamin D is an extremely important vitamin that has powerful effects on several systems throughout your body (1Trusted Source).

Unlike other vitamins, vitamin D functions like a hormone, and every single cell in your body has a receptor for it.

Your body makes it from cholesterol when your skin is exposed to sunlight.

It’s also found in certain foods such as fatty fish and fortified dairy products, though it’s very difficult to get enough from diet alone.

The recommended daily intake (RDI) is usually around 400–800 IU, but many experts say you should get even more than that.

Vitamin D deficiency is very common. It’s estimated that about 1 billion people worldwide have low levels of the vitamin in their blood (2Trusted Source).

According to a 2011 study, 41.6% of adults in the US are deficient. This number goes up to 69.2% in Hispanics and 82.1% in African-Americans (3Trusted Source).

Here are 7 common risk factors for vitamin D deficiency:

  • Having dark skin.
  • Being elderly.
  • Being overweight or obese.
  • Not eating much fish or dairy.
  • Living far from the equator where there is little sun year-round.
  • Always using sunscreen when going out.
  • Staying indoors.

People who live near the equator and get frequent sun exposure are less likely to be deficient, as their skin produces enough vitamin D to satisfy their bodies’ needs.

Most people don’t realize that they’re deficient, as symptoms are generally subtle. You may not recognize them easily, even if they’re having a significant negative effect on your quality of life.

Here are 8 signs and symptoms of vitamin D deficiency.

1. Getting Sick or Infected Often

One of vitamin D’s most important roles is keeping your immune system strong so you’re able to fight off viruses and bacteria that cause illness.

It directly interacts with the cells that are responsible for fighting infection (4Trusted Source).

If you often become sick, especially with colds or the flu, low vitamin D levels may be a contributing factor.

Several large observational studies have shown a link between a deficiency and respiratory tract infections like colds, bronchitis and pneumonia (5Trusted Source, 6Trusted Source).

A number of studies have found that taking vitamin D supplements at a dosage of up to 4,000 IU daily may reduce your risk of respiratory tract infections (7Trusted Source, 8Trusted Source, 9Trusted Source).

In one study in people with the chronic lung disorder COPD, only those who were severely deficient in vitamin D experienced a significant benefit after taking a high-dose supplement for one year (10Trusted Source).

Summary Vitamin D plays important roles in immune function. One of the most common symptoms of deficiency is an increased risk of illness or infections.

2. Fatigue and Tiredness

Feeling tired can have many causes, and vitamin D deficiency may be one of them.

Unfortunately, it’s often overlooked as a potential cause.

Case studies have shown that very low blood levels can cause fatigue that has a severe negative effect on quality of life (11Trusted Source, 12Trusted Source).

In one case, a woman who complained of chronic daytime fatigue and headaches was found to have a vitamin D blood level of only 5.9 ng/ml. This is extremely low, as anything under 20 ng/ml is considered deficient.

When the woman took a vitamin D supplement, her level increased to 39 ng/ml and her symptoms resolved (12Trusted Source).

However, even blood levels that aren’t extremely low may have a negative impact on your energy levels.

A large observational study looked at the relationship between vitamin D and fatigue in young women.

The study found that women with blood levels lower than 20 ng/ml or 21–29 ng/ml were more likely to complain of fatigue than those with blood levels over 30 ng/ml (13Trusted Source).

Another observational study in female nurses found a strong connection between low vitamin D levels and self-reported fatigue.

What’s more, the researchers found that 89% of the nurses were deficient (14Trusted Source).

For more information on how to reduce fatigue, consider reading about the 11 best vitamins and supplements to boost energy.

Summary Excessive fatigue and tiredness may be a sign of vitamin D deficiency. Taking supplements may help improve energy levels.

3. Bone and Back Pain

Vitamin D helps maintain bone health in a number of ways.

For one, it improves your body’s absorption of calcium.

Bone pain and lower back pain may be signs of inadequate vitamin D levels in the blood.

Large observational studies have found a relationship between a deficiency and chronic lower back pain (15Trusted Source, 16Trusted Source, 17Trusted Source).

One study examined the association between vitamin D levels and back pain in more than 9,000 older women.

The researchers found that those with a deficiency were more likely to have back pain, including severe back pain that limited their daily activities (17Trusted Source).

In one controlled study, people with vitamin D deficiency were nearly twice as likely to experience bone pain in their legs, ribs or joints compared to those with blood levels in the normal range (18Trusted Source).

Summary Low blood levels of vitamin D may be a cause or contributing factor to bone pain and lower back pain.

4. Depression

A depressed mood may also be a sign of vitamin D deficiency.

In review studies, researchers have linked vitamin D deficiency to depression, particularly in older adults (19Trusted Source, 20Trusted Source).

In one analysis, 65% of the observational studies found a relationship between low blood levels and depression.

On the other hand, most of the controlled trials, which carry more scientific weight than observational studies, didn’t show a link between the two (19Trusted Source).

However, the researchers who analyzed the studies noted that the dosages of vitamin D in controlled studies were often very low.

In addition, they observed that some of the studies may not have lasted long enough to see the effect of taking supplements on mood.

Some controlled studies have shown that giving vitamin D to people who are deficient helps improve depression, including seasonal depression that occurs during the colder months (21Trusted Source, 22Trusted Source).

Summary Depression is associated with low vitamin D levels and some studies have found that supplementing improves mood.

5. Impaired Wound Healing

Slow healing of wounds after surgery or injury may be a sign that your vitamin D levels are too low.

Results from a test-tube study suggest that the vitamin increases the production of compounds that are crucial for forming new skin as part of the wound-healing process (23Trusted Source).

One study on people who had dental surgery found that certain aspects of healing were compromised by vitamin D deficiency (24Trusted Source).

It’s also been suggested that vitamin D’s role in controlling inflammation and fighting infection is important for proper healing.

One analysis looked at patients with diabetic foot infections.

It found that those with severe vitamin D deficiency were more likely to have higher levels of inflammatory markers that can jeopardize healing (25Trusted Source).

Unfortunately, there is very little research about the effects of vitamin D supplements on wound healing in people with deficiency at this point.

However, one study found that when vitamin D deficient patients with leg ulcers were treated with the vitamin, ulcer size reduced by on 28%, on average (26Trusted Source).

Summary Inadequate vitamin D levels may lead to poor wound healing following surgery, injury or infection.

6. Bone Loss

Vitamin D plays a crucial role in calcium absorption and bone metabolism.

Many older people who are diagnosed with bone loss believe they need to take more calcium. However, they may be deficient in vitamin D as well.

Low bone mineral density is an indication that your bones have lost calcium and other minerals. This places older adults, especially women, at an increased risk of fractures.

In a large observational study in more than 1,100 middle-aged women in menopause or postmenopause, researchers found a strong link between low vitamin D levels and low bone mineral density (27Trusted Source).

However, a controlled study found that women who were vitamin D deficient experienced no improvement in bone mineral density when they took high-dose supplements, even if their blood levels improved (28Trusted Source).

Regardless of these findings, adequate vitamin D intake and maintaining blood levels within the optimal range may be a good strategy for protecting bone mass and reducing fracture risk.

Summary A diagnosis of low bone mineral density may be a sign of vitamin D deficiency. Getting enough of this vitamin is important for preserving bone mass as you get older.

7. Hair Loss

Hair loss is often attributed to stress, which is certainly a common cause.

However, when hair loss is severe, it may be the result of a disease or nutrient deficiency.

Hair loss in women has been linked to low vitamin D levels, though there is very little research on this to date (29Trusted Source).

Alopecia areata is an autoimmune disease characterized by severe hair loss from the head and other parts of the body. It’s associated with rickets, which is a disease that causes soft bones in children due to vitamin D deficiency (30Trusted Source).

Low vitamin D levels are linked to alopecia areata and may be a risk factor for developing the disease (31Trusted Source, 32Trusted Source, 33Trusted Source).

One study in people with alopecia areata showed that lower vitamin D blood levels tended to be associated with a more severe hair loss (33Trusted Source).

In a case study, topical application of a synthetic form of the vitamin was found to successfully treat hair loss in a young boy with a defect in the vitamin D receptor (34Trusted Source).

Many other foods and nutrients may affect the health of your hair. If you experience hair loss, you may be interested in the 14 best foods for hair growth.

Summary Hair loss may be a sign of vitamin D deficiency in female-pattern hair loss or the autoimmune condition alopecia areata.

8. Muscle Pain

The causes of muscle pain are often difficult to pinpoint.

There is some evidence that vitamin D deficiency may be a potential cause of muscle pain in children and adults (35Trusted Source, 36Trusted Source, 37Trusted Source).

In one study, 71% of people with chronic pain were found to be deficient (37Trusted Source).

The vitamin D receptor is present in nerve cells called nociceptors, which sense pain.

One study in rats showed that a deficiency led to pain and sensitivity due to stimulation of nociceptors in muscles (38Trusted Source).

A few studies have found that taking high-dose vitamin D supplements may reduce various types of pain in people who are deficient (39Trusted Source, 40Trusted Source).

One study in 120 children with vitamin D deficiency who had growing pains found that a single dose of the vitamin reduced pain scores by an average 57% (40Trusted Source).

Summary There is a link between chronic pain and low blood levels of vitamin D, which may be due to the interaction between the vitamin and pain-sensing nerve cells.

The Bottom Line

Vitamin D deficiency is incredibly common and most people are unaware of it.

That’s because the symptoms are often subtle and non-specific, meaning that it’s hard to know if they’re caused by low vitamin D levels or something else.

If you think you may have a deficiency, it’s important that you speak to your doctor and get your blood levels measured.

Fortunately, a vitamin D deficiency is usually easy to fix.

You can either increase your sun exposure, eat more vitamin-D-rich foods, such as fatty fish or fortified dairy products. You can also find a variety of vitamin D supplements on Amazon.

Fixing your deficiency is simple, easy and can have big benefits for your health.

Medically reviewed by Franziska Spritzler, RD, CDE — Written by on July 23, 2018

Source: 8 Signs and Symptoms of Vitamin D Deficiency

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Here are the warning signs of vitamin D deficiency most people ignore! Over 40% of American adults, and approximately 1 billion people worldwide are deficient in vitamin D. That’s a lot of people walking around lacking in this vital nutrient. As you may already know, lack of vitamins or a vitamin deficiency can cause serious health consequences if not addressed. Because low vitamin D levels are affecting so many people across the globe, it’s important to learn the signs and symptoms of vitamin D deficiency. Since vitamin D has receptors throughout the body, it’s imperative that you get adequate amounts in order to stay healthy. If you suspect that you may need more vitamin D based on this list, it’s best to talk to your doctor and get your blood levels checked. The good news is that a deficiency of vitamin D is easy to fix if your levels are lower than adequate. You can either you get more sunlight, consume more foods high in Vitamin D, or take a supplement. —————————————————————— Music: Epidemic Sound Visuals: VideoBlocks / Dreamstime / Other Audio & Video Production by Brainy Dose

Vitamins, Minerals and Supplements: how to Naturally Boost your Health (and more!)

Vitamins and Minerals (also known as Micronutrients)are important substances that allow your body to function and stay healthy. If you already have a balanced diet, you probably do not need to take them as supplements, and yet in some cases people should. This article is the result of a collaboration with Annalisa Brigo, a Nutrition […]

via Vitamins, Minerals and Supplements: how to Naturally Boost your Health (and more!) [Collaboration Post]. — THE PHYSIO FORMULA

Top Surgeon : How To Proporly Wash Out Your Bowels – Gundry MD

Millions of Americans suffer from low energy, digestive discomfort, and trouble losing weight. Many also experience achy muscles and joints, skin problems, headaches, and even frequent colds. “If you’re experiencing any of these health issues, the real problem may be Leaky Gut,” says Dr. Steven Gundry. According to Dr. Gundry — who has studied leaky gut for over 20 years — certain foods can cause tears in our gut lining. This, in turn, allows toxins to enter our body that lead to digestive discomfort, food cravings, fatigue, weight gain, and even more health issues…..

Source: https://thenewgutfix.com/leaky-gut-fix_181102A.php?n=rev

The Highs & Lows of Testosterone – Randi Hutter Epstein

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Getting a high testosterone reading offers bragging rights for some men of a certain age and may explain in part the lure of testosterone supplements. But once you are within a normal range, does your level of testosterone, the male hormone touted to build energy, libido and confidence, really tell you that much? Probably not, experts say. Normal testosterone levels in men range from about 300 to 1,000 nanograms per deciliter of blood. Going from one number within the normal zone to another one may not pack much of a punch.

Read more: https://www.nytimes.com/2018/03/27/well/live/testosterone-supplements-low-t-treatment-libido.html

 

 

 

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