Cambridge Artificial Pancreas Proves Life Changing For Young Diabetics

Management of type 1 diabetes is a difficult balancing act that involves finger-prick sampling and insulin injections to keep blood glucose levels in check, but the notion of an “artificial pancreas” promises to lighten the load.

Scientists at the University of Cambridge have been pushing the boundaries of this technology for more than a decade and have now reported promising findings from trials in very young children, where their solution produced “life-changing” results.

Back in 2020, University of Cambridge scientists launched what was billed as the world’s first licensed, downloadable artificial pancreas smartphone app for type 1 diabetes.

Like other artificial pancreas technologies under development, the idea is to fulfill the role of the pancreas in diabetes sufferers, where it is no longer able to produce the insulin needed to absorb glucose from the blood.

The team’s CamAPS FX smartphone app works with a glucose monitor and pump, using a complex algorithm to determine when the user is in need of insulin and delivering it as needed.

The newly published study was designed to investigate how the technology can benefit young children, in which type 1 diabetes management is particularly problematic due to irregular eating and activity, along with high variability in the amount of insulin they require.

The study involved 74 children with type 1 diabetes, aged one to seven, with all subjects using the CamAPS FX artificial pancreas system for 16 weeks.

They then used current technology called sensor-augmented pump therapy, in which parents monitor their child’s glucose levels and manually adjust insulin delivery via a pump, also for 16 weeks. This allowed the scientists to compare the performance of the two.

“CamAPS FX makes predictions about what it thinks is likely to happen next based on past experience,” explains study author Professor Roman Hovorka. “It learns how much insulin the child needs per day and how this changes at different times of the day.

It then uses this to adjust insulin levels to help achieve ideal blood sugar levels. Other than at mealtimes, it is fully automated, so parents do not need to continually monitor their child’s blood sugarlevels.

“CamAPS FX makes predictions about what it thinks is likely to happen next based on past experience,” explains study author Professor Roman Hovorka. “It learns how much insulin the child needs per day and how this changes at different times of the day.

It then uses this to adjust insulin levels to help achieve ideal blood sugar levels. Other than at mealtimes, it is fully automated, so parents do not need to continually monitor their child’s blood sugar levels.”

When using the CamAPS FX app, the children spent 71.6 percent of their day in the target range for glucose levels, around nine percentage points, or 125 additional minutes, higher than the control.

They also spent 22.9 percent of the time with raised blood sugar levels, nine percentage points lower than the control, and also exhibited lower average blood sugar levels, reducing their risk of diabetes-related complications.

“Very young children are extremely vulnerable to changes in their blood sugar levels,” said Dr. Julia Ware, the study’s first author. “High levels in particular can have potentially lasting consequences to their brain development. On top of that, diabetes is very challenging to manage in this age group, creating a huge burden for families.

CamAPS FX led to improvements in several measures, including hyperglycemia and average blood sugar levels, without increasing the risk of hypos. This is likely to have important benefits for those children who use it.”

This study marks the first time the CamAPS FX system has been proven effective in very young children over a period of several months, with parents describing it as “life-changing.”

As it stands, the technology is available through certain hospital trusts in the UK, but the scientists hope as it continues to prove itself through these types of trials, it can change the lives of more and more sufferers of the condition.

From the first clinical trials of our algorithms to today’s findings has taken well over a decade, but the dedication of my team and the support of all the children and families who have taken part in our studies, has paid off,” Hovorka said. “We believe our artificial pancreas will transform the lives of families with very young children affected by type 1 diabetes.”

Nick Lavars

By:Nick Lavars

Source: Cambridge artificial pancreas proves “life-changing” for young diabetics

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Diabetes Fact sheet N°312”. World Health Organization. August 2011. Archived from the original on 26 August 2013. Retrieved 2012-01-09.

“Diabetes Blue Circle Symbol”. International Diabetes Federation. 17 March 2006. Archived from the original on 5 August 2007.

“Diagnosis of Diabetes and Prediabetes”. National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 6 March 2016. Retrieved 10 February 2016.

Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment”. Diabetes Care. 37 (11): 3124–31. doi:10.2337/dc14-0984. PMC 4207202. PMID 25342831.

“Causes of Diabetes”. National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 2 February 2016. Retrieved 10 February 2016.

What’s Worse Than a Pandemic? A Twindemic

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On the record of issues to fret about within the age of SARS-CoV-2, boring, outdated winter flu most likely doesn’t rank extremely. Particularly not in the course of a summer season warmth wave. And but it ought to.

Humanity has grown so accustomed to annual waves of influenza that it was the baseline comparability when Covid first arrived. (It’ll be simply one other flu, we stated.) The implication was that ranges of influenza illness, hospitalization and loss of life have been acceptable, even inevitable.

I used to be definitely responsible of that considering. Though my employer provides an annual flu shot, I typically didn’t hassle to get it. However the pandemic has uncovered the weak spot of our attitudes and insurance policies towards influenza. We now have a possibility to do issues otherwise. This isn’t an argument for flu-driven lockdowns or a nationwide paranoia about any bug. However we are able to construct higher defenses towards influenza at comparatively little value, and for a acquire in lives and health-care capability.

One purpose to get extra severe about flu is its value, each economically and in human phrases. Annual prices of treating influenza (routinely in extra of $10 billion within the U.S.) are vital, even whenever you simply have a look at hospital outlays for these most severely affected.

Influenza epidemics within the northern hemisphere have an effect on anyplace from 5% to fifteen% of the inhabitants yearly. On common, about 8% of the U.S. inhabitants get sick from flu every season. For many, it’s normally a light, if disagreeable expertise. However for some, it may be lethal.

The U.S. Facilities for Illness Management estimates that, on common, 36,000 folks have died of flu every year during the last decade, with 61,000 deaths within the 2017-2018 flu season. Within the U.Okay., the common is about 17,000 annual deaths. Clearly, Covid is a unique order of magnitude, however the prices to the health-care system from flu should not trivial.

The aged are most susceptible to flu, however so are pregnant ladies, very younger youngsters and people with different medical circumstances and weakened immune methods. Some who contract and recuperate from flu find yourself with post-viral signs that drag on. Lengthy Covid has confirmed us simply how debilitating these could be.

What occurs whenever you layer flu on high of Covid-19? We don’t actually know, since final winter noticed an extremely delicate flu season, principally as a consequence of measures equivalent to lockdowns, social distancing and masking. Infections charges for flu have been two-thirds decrease than in the course of the 2011-2012 season, which had file low charges.

We are able to’t depend on a repeat. The low prevalence of flu final 12 months makes it tougher to foretell which strains to incorporate on this winter’s vaccine. We might get fortunate once more, or issues might worsen: Lowered ranges of pure immunity after a couple of low-flu seasons might make it simpler for brand new variants to take maintain.

Britain, with its overstretched nationwide health-care system and gargantuan backlog of surgical procedures and different procedures, can scarcely afford a foul flu season. Consultations for influenza-like diseases take up substantial GP time and hospital capability in a standard 12 months. Excessive charges of flu on high of Covid can be a pressure too far, requiring substantial new authorities sources and leaving many individuals with out remedy.

However it’s not simply the compounded well being burden that ought to make us rethink influenza. The very fact is, we’ve got been far too complacent about flu for too lengthy. Many flu deaths are preventable with jabs and the sorts of behavioral modifications we’ve grown accustomed to from Covid.

Not solely did the social-distancing measures imposed in the course of the pandemic lower the unfold of flu, they’re additionally estimated to have led to a 20% drop within the widespread respiratory syncytial virus (RSV) within the U.S. RSV accounts for five% of the deaths in youngsters below 5 globally. The issue now, nonetheless, is that the current lifting of Covid restrictions has coincided with unseasonably excessive RSV circumstances within the U.S.

Larger ranges of flu vaccination can be a game-changer. Final winter, flu vaccine uptake in Britain reached file ranges, with the Nationwide Well being Service vaccinating greater than 80% of these over 65 — 10% increased than the earlier 12 months and forward of the World Well being Group purpose of 75% for the primary time.

However the vaccination price drops off with the younger. Lower than 45% of these below 65 with a number of underlying danger components will get vaccinated. Though greater than 2.5 million youngsters have been vaccinated by means of college packages, that’s nonetheless properly below half (47.5%) of all children. Uptake additionally varies throughout ethnic teams, with some minorities lagging in getting vaccines. Within the U.S., Black communities (the place vaccine charges are round 41%) had the best flu-related hospitalization price of any ethnicity.

A examine on the College of Bristol is presently searching for to find out what negative effects folks get when given the really useful flu vaccine together with both the Oxford/AstraZeneca or the Pfizer/BioNTech vaccines. Getting a joint Covid-19 booster shot and flu shot might guarantee that there’s extra flu vaccine protection.

In fact, the effectiveness of flu vaccines can range from one season to the following and from individual to individual. They’re usually between 40% and 60% efficient once they match up properly with the variants circulating.

So we’d be properly served to additionally apply our Covid habits to diseases like flu. Which may imply extra hybrid working throughout peak flu months or if there’s an outbreak. Masking at sure occasions, even when not obligatory, makes loads of sense too.

If Covid-19, like flu, goes to be a recurrent seasonal affliction — as appears possible — we might want to higher handle the stress on the well being methods in the course of the winter. Meaning being ready to finance increased ranges of care throughout these crunch intervals or doing extra to cut back the pressure on the system. We’ll most probably by no means remove influenza and different viruses, however we are able to make winters more cost effective and fewer depressing by elevating the bar on an sickness that many people handled too casually.

Source: What’s worse than a pandemic? A twindemic | Asia Post

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Critics:

As public health officials look to fall and winter, the specter of a new surge of Covid-19 gives them chills. But there is a scenario they dread even more: a severe flu season, resulting in a “twindemic.”

Even a mild flu season could stagger hospitals already coping with Covid-19 cases. And though officials don’t know yet what degree of severity to anticipate this year, they are worried large numbers of people could forgo flu shots, increasing the risk of widespread outbreaks.

The concern about a twindemic is so great that officials around the world are pushing the flu shot even before it becomes available in clinics and doctors’ offices. Dr. Robert Redfield, director of the U.S. Centers for Disease Control and Prevention has been talking it up, urging corporate leaders to figure out ways to inoculate employees. The C.D.C. usually purchases 500,000 doses for uninsured adults but this year ordered an additional 9.3 million doses.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, has been imploring people to get the flu shot, “so that you could at least blunt the effect of one of those two potential respiratory infections.”

The flu vaccine is rarely mandated in the U.S. except by some health care facilities and nursery schools, but this month the statewide University of California system announced that because of the pandemic, it is requiring all 230,000 employees and 280,000 students to get the flu vaccine by November 1.

According to the C.D.C., flu season occurs in the fall and winter, peaking from December to February, and so was nearing its end as the pandemic began to flare in the United States in March.

Vaccine mandates are controversial. They’re also effective.

Guam tries to revive tourism with vaccine vacations.

Chicago will require masks in school this fall, regardless of vaccination status.

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Is Patient Financing Right for Your Health Practice?

In these times of post-pandemic financial uncertainty, additional return on investment for medical providers is more welcome than ever. Patient financing — which for the purposes of this article means partnering with an external lender to provide service and procedure payments — can produce not just steady income for a practice, but help ensure that patients won’t have to put off procedures or, worse yet, abandon them altogether.

For example, Toronto Plastic Surgeons provides this facility to its patients through Medicard Patient Financing. There are also veterinary financing services for pets available through Medicard Patient Financing. What are some reasons practitioners might have employed in deciding upon this option?

No More Delays

There are, unfortunately, economic disparities when it comes to accessing healthcare services. Too often, the high-income and privileged have more access to healthcare resources than the medium- and low-income populations. Patient financing can help in reducing this imbalance, because the simple and daunting truth is that many medical problems don’t come announced, and it’s often impossible to plan for their associated expenses. With financing, patients don’t need to wait to get their accounts in order before opting for procedures — the result is, ideally, prompt and less stressful treatment.

Related: Fintech fuelling growth in Healthcare Financial Industry

Increased Patient Satisfaction

Since clients can often better manage their expenses via patient financing, they tend to be more satisfied on the whole. In part this is because they are not stressed and burdened with sudden financial decisions associated with urgent medical procedures. Better yet, they are more likely to stay loyal to a practice if they don’t have to worry as much. Compared to other practices that don’t offer this option, they are more likely to choose the former, which can mean increased business through word of mouth.

Reduced Collection Costs

When you partner with a patient financer, you receive payments on time. It also means that your team won’t spend needless hours and energy trying to collect payments.

Steady Cash Flow and Less Bad Debt

In setting up a conventional payment plan for a patient, your team is taking the responsibility of keeping tabs on payments and collecting them on time. It’s essentially extending a loan to a patient, typically without any interest. However, expenses like bills, payroll and lease/rent go on as usual. This can lead to tied up in , which will easily and quickly impact a budget. But when you opt for association with a patient financing company, the latter bears the cost of collections, including giving you the option of getting payment upfront.

Related: Healthcare is in Turmoil, But Technology Can Save Businesses Billions

Better Marketing

Association with a financing company with its own marketing arm can help promote a business — making your clinic stand out in comparison to competitors.

Which to Choose?

When it comes to financing models, three predominate. In the first, Self-Funding, you as the healthcare provider are responsible for receivables. From creating a payment schedule to collecting funds to following up with the patient, your team carries out all the tasks. In the Recourse Lending model, you work with a patient financier/lender, which will approve a patient’s loan after the business/practice passes qualifying criteria.

If the patient doesn’t pay, the lending/financing company will recover the losses from you. Among the drawbacks here is that the practice will have to bear the losses and lender’s fees. Lastly, there is the Non-Recourse Lending model. Similar to the second, you work with a lending company. Key differences are that it is the patient who has to pass the underwriting criteria (if the lender doesn’t approve the patient, no funding is provided by them), and that losses are borne by the lender. One disadvantage of this method is that the lenders charge interest from patients; when rates are high, patients might not be interested. Also, patients with a weak credit history might be rejected during the underwriting evaluation.

By : Chris Porteous / Entrepreneur Leadership Network Contributor – High Performance Growth Marketer

Source: Is Patient Financing Right for Your Health Practice?

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Critics:

Publicly funded healthcare is a form of health care financing designed to meet the cost of all or most healthcare needs from a publicly managed fund. Usually this is under some form of democratic accountability, the right of access to which are set down in rules applying to the whole population contributing to the fund or receiving benefits from it.

The fund may be a not-for-profit trust that pays out for healthcare according to common rules established by the members or by some other democratic form. In some countries, the fund is controlled directly by the government or by an agency of the government for the benefit of the entire population. That distinguishes it from other forms of private medical insurance, the rights of access to which are subject to contractual obligations between an insured person (or their sponsor) and an insurance company, which seeks to make a profit by managing the flow of funds between funders and providers of health care services.

When taxation is the primary means of financing health care and sometimes with compulsory insurance, all eligible people receive the same level of cover regardless of their financial circumstances or risk factors.

Most developed countries have partially or fully publicly funded health systems. Most western industrial countries have a system of social insurance based on the principle of social solidarity that covers eligible people from bearing the direct burden of most health care expenditure, funded by taxation during their working life.

Among countries with significant public funding of healthcare there are many different approaches to the funding and provision of medical services. Systems may be funded from general government revenues (as in Canada, United Kingdom, Brazil and India) or through a government social security system (as in Australia, France, Belgium, Japan and Germany) with a separate budget and hypothecated taxes or contributions.

The proportion of the cost of care covered also differs: in Canada, all hospital care is paid for by the government, while in Japan, patients must pay 10 to 30% of the cost of a hospital stay. Services provided by public systems vary. For example, the Belgian government pays the bulk of the fees for dental and eye care, while the Australian government covers eye care but not dental care.

Publicly funded medicine may be administered and provided by the government, as in the Nordic countries, Portugal, Spain, and Italy; in some systems, though, medicine is publicly funded but most hospital providers are private entities, as in Canada. The organization providing public health insurance is not necessarily a public administration, and its budget may be isolated from the main state budget. Some systems do not provide universal healthcare or restrict coverage to public health facilities. Some countries, such as Germany, have multiple public insurance organizations linked by a common legal framework. Some, such as the Netherlands and Switzerland, allow private for-profit insurers to participate.

See also

Regeneron Says Antibody Therapy Prevents COVID-19 Infections

Regeneron Pharmaceuticals is planning to ask the Food and Drug Administration (FDA) to allow its antibody cocktail to be used as a preventive treatment for COVID-19, the company said Monday.

New results from a clinical trial conducted with the National Institute of Allergy and Infectious Diseases found the drug reduced the risk of symptomatic infection by 81 percent in people who were not infected at the start of the trial, Regeneron said.

The company has already received emergency use authorization from the FDA to use its antibody drugs to treat adults with mild to moderate COVID-19 and pediatric patients at least 12 years old who have tested positive for the virus and are at high risk of severe disease but are not yet hospitalized.

The trial enrolled 1,505 people who were not infected with the virus but lived in the same household as someone who recently tested positive. The patients were randomized to receive either one dose of the antibody therapy or a placebo administered as injections.

After 29 days, 11 people out of the 753 who received a single 1,200 mg dose of the treatment developed symptomatic COVID-19; 59 people who received a placebo out of 752 participants developed symptomatic COVID-19.

The drug provided 72 percent protection against symptomatic infections in the first week and 93 percent protection in subsequent weeks, Regeneron said. The data has not yet been peer reviewed or published.

Regeneron also said the trial found individuals treated with the therapy who experienced a symptomatic infection resolved their symptoms in one week, compared to three weeks with placebo. Infected individuals also cleared the virus faster with the therapy, the company said.

Adverse events occurred in 20 percent of patients who received the antibody drug and 29 percent of those who received a placebo, Regeneron said, but nobody withdrew from the trial because of them.

None of the participants who received the therapy were hospitalized or went to the ER because of COVID-19 over the course of 29 days; four in the placebo group did so. There were four deaths in the trial — two in the therapy group and two in the placebo group — but none were reported due to COVID-19 or the drug.

“With more than 60,000 Americans continuing to be diagnosed with COVID-19 every day, the REGEN-COV antibody cocktail may help provide immediate protection to unvaccinated people who are exposed to the virus, and we are also working to understand its potential to provide ongoing protection for immunocompromised patients who may not respond well to vaccines,” George Yancopoulos, president and chief scientific officer at Regeneron, said in a statement.

The trial tested the antibody treatment for use as a “passive vaccine,” which involves directly injecting antibodies into the body. Traditional vaccines rely on a person’s immune system to activate and develop its own antibodies.

That means the treatment may provide immediate benefits, in contrast to active vaccines, which take weeks to provide protection. In addition, using injections rather than an infusion could make administering it more convenient than the currently authorized use for antibody drugs.

While much of the attention has been focused on vaccines, experts say therapeutic treatments are just as important to ending the pandemic, which has killed more than 562,000 Americans.

Source: Regeneron says antibody therapy prevents COVID-19 infections | TheHill

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The Strange Story Of Remdesivir, A Covid Drug That Doesn’t Work

Remdesivir in a syringe.

While clinical trials suggest remdesivir isn’t very effective in treating Covid-19, recent studies have shown that it does block Coronavirus activity. That apparent contradiction makes the antiviral drug even more controversial.

Remdesivir is an experimental drug developed by biotech company Gilead Sciences (under the brand name Veklury) in collaboration with the US Centers for Disease Control and Army Medical Research Institute of Infectious Diseases.

It’s one of many drug candidates that were originally designed in response to the threat from emerging diseases caused by RNA viruses — germs like the one behind the 2002 SARS outbreak — that have potential to cause global pandemics.

Such ‘broad-spectrum’ drugs target features shared by a wide range of disease-causing germs. In remdesivir’s case, that’s the virus’ genetic material, RNA. The drug proved ineffective against the Ebola virus, however, yet was still subsequently repurposed for SARS-CoV-2 coronavirus.

Remdesivir is not effective for Covid

News media prematurely reported that patients were responding to treatment. But the published data lated showed that “remdesivir was not associated with statistically significant clinical benefits [and] the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.”

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As our special series On the Front Lines continues, NBC’s Joe Fryer profiles one of the country’s first COVID-19 patients, Raymond Sismaet, who spent nearly a month in a hospital before recovering. His story spotlights the antiviral drug remdesivir as a possible coronavirus treatment. » Subscribe to TODAY: http://on.today.com/SubscribeToTODAY » Watch the latest from TODAY: http://bit.ly/LatestTODAY About: TODAY brings you the latest headlines and expert tips on money, health and parenting. We wake up every morning to give you and your family all you need to start your day.
If it matters to you, it matters to us. We are in the people business. Subscribe to our channel for exclusive TODAY archival footage & our original web series. Connect with TODAY Online! Visit TODAY’s Website: http://on.today.com/ReadTODAY Find TODAY on Facebook: http://on.today.com/LikeTODAY Follow TODAY on Twitter: http://on.today.com/FollowTODAY Follow TODAY on Instagram: http://on.today.com/InstaTODAY Follow TODAY on Pinterest: http://on.today.com/PinTODAY #Coronavirus #Remdesivir #TodayShow

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The controversy surrounding remdesivir therefore revolves around whether the drug is actually an effective treatment. Early studies produced conflicting evidence on remdesivir’s effectiveness. Some found that Covid patients who received the drug recovered faster and fewer people died, but other studies showed that it didn’t reduce the length of hospitalization or death rate.

What’s weird about remdesivir is that it hasn’t been held to the same standards as other drug candidates. Covid-19 vaccines have been developed 10 times faster than traditional drugs, but they’ve passed the phase-3 clinical trials that test whether a potential medicine is both safe and effective in thousands of people.

Normally, a drug is only approved for use by a regulatory body like the US Food and Drug Administration if it meets the two criteria for safety and efficacy. Nonetheless, in October 2020, remdesivir was granted approval by FDA based on promising data from relatively small trials with about 1000 participants.

A large-scale analysis by the World Health Organization’s Solidarity trial consortium has cleared-up the confusion. Based on interim results from studying more than 5000 participants, the international study concluded that remdesivir “had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.”

As a consequence of being mostly ineffective, WHO recommends against the use of remdesivir in Covid-19 patients.

Remdesivir is an expensive drug

The drug is administered over 5 or 10 days. A five-day course of treatment costs around $2600 per person. So for a hospital with hundreds of Covid patients, that would amount to millions of dollars for one antiviral.

That price could be cost-effective if remdesivir saved lives and its use was limited to moderate or severe disease, but it’s also being made available for milder cases and WHO found that it isn’t a lifesaving drug.

What next for remdesivir? Following WHO’s finding, an article in the British Medical Journal highlighted another antiviral as a cautionary tale: oseltamivir or ‘Tamiflu’ — a drug that aims to block the influenza virus.

During the early 2000s, governments started stockpiling Tamiflu, paying billions to its manufacturer, pharmaceutical firm Roche. Then in 2013, independent researchers gained access to Roche’s unpublished data, revealing that the drug caused many side effects and only shortened the duration of flu symptoms by a few hours.

Tamiflu only cost $75 per treatment and yet was still a massive waste of money. The BMJ article implies that the story of remdesivir is another scandal waiting to happen.

Given that remdesivir is expensive and doesn’t seem to save lives, does it have any value? Maybe — but not as a medicine itself. Recent research suggests scientists should at least keep studying how it works in order to develop better drugs.

Remdesivir does block Coronavirus

Remdesivir doesn’t prevent people from being infected by the SARS-CoV-2 virus.

Whereas a vaccine is designed prompt your immune system to recognize the spike protein that allows Coronavirus to invade cells — and protect people from infection — antivirals such as remdesivir aim to disrupt the virus’ ability to replicate, to slow its spread and give your body extra time to develop immunity.

Coronaviruses use RNA for their genetic material — not the DNA used by cells — which means that they need a special molecular machine to copy their genes when producing new virus particles. That machine, ‘RNA polymerase’, is what’s targeted by remdesivir.

Two studies have now revealed how remdesivir blocks SARS-CoV-2 at the molecular level.

First, chemical engineers at the University of Chicago found that remdesivir is better at reducing virus replication than two similar antivirals, ribavirin and favilavir. Their computer models suggest that remdesivir beats the other drugs because it’s the best at binding and destabilizing the RNA polymerase.

In the second new study, researchers at the University of Texas at Austin used ‘cryogenic-electron microscopy’ (cryo-EM) to take snapshots of the structure of the molecules involved in replication as they would interact in a Covid patient.

After adding remdesivir to RNA polymerase, cryo-EM images showed that the drug acts like a blockage in a photocopier, getting stuck in the RNA polymerase. When four molecules of remdesivir get between the gears of the polymerase machine, its copies of RNA ‘paper’ can no longer pass through, stalling the virus-copying process.

That leads us to why it’s worth studying remdesivir. As structural biologist David Taylor explains, “We were able to identify the point where that paper jam happens […] If we want to make the blockage even worse, we could do so.”

One of remdesivir’s flaws is its (possibly toxic) high dosage over a short timeframe, which contributes to adverse side effects. By tweaking the drug molecule’s structure, scientists may be able to make it block the RNA polymerase machine with fewer molecules, which would then allow the drug to be delivered in a smaller dose.

In fact, Gilead Sciences has already isolated a compound similar to remdesivir, GS-441524, which costs less and is easier to manufacture. It’s also simpler to administer: while remdesivir must be injected, GS-441524 could be ingested in pill form. More of the molecule reaches the lungs — the main site of infection — too, which led researchers to state that “GS-441524 is superior to remdesivir for Covid-19 treatment.”

As SARS-CoV-2’s genetic material mutates to create new strains of the virus — and variants of Covid-19 — we may need antivirals to buy us time if those new strains end-up evading our current vaccines.

So despite being expensive and ineffective at treating Covid, remdesivir’s true value could be to help researchers create more effective medicines.

Follow me on Twitter or LinkedIn. Check out my website or some of my other work here.

I’m a science communicator specialising in public engagement and outreach through entertainment, focusing on popular culture. I have a PhD in evolutionary biology and spent several years at BBC Science Focus magazine, running the features section and writing about everything from gay genes and internet memes to the science of death and origin of life. I’ve also contributed to Scientific American and Men’s Health. My latest book is ’50 Biology Ideas You Really Need to Know’

Source: The Strange Story Of Remdesivir, A Covid Drug That Doesn’t Work

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Day before procurement starts, trucks carrying illegal wheat from Bihar found in Bathinda : The Tribune India
[…] 3 hours ago Govt prohibits exports of remdesivir till COVID situation improves in India Drugs inspectors, other officers directed to verify stocks, […]
58
RTPCR negative report mandatory for those coming to Chhattisgarh by rail, air route: CM Baghel instructs officials | Law-Order
[…] He has instructed the Chief Secretary that for smooth supply of Remdesivir injection in the state, senior officers should be sent to Hyderabad and Maharashtra fo […] this issue with the President of the Drug Association and asked him to increase the supply of Remdesivir Injection from other states […]
0
Lockdown Needed, But Decision After Wednesday: Maharashtra Minister Rajesh Tope
[…] with the State Task Force, the chief minister discussed the availability of oxygen & beds, use of Remdesivir, treatment protocols, increase in capacity of facilities, imposition of restrictions & fines fo […] in a meeting with the State Task Force discussed the availability of oxygen & beds, use of Remdesivir, treatment protocols, increase in capacity of facilities, imposition of restrictions & fines fo […]
16
India finalises air bubble pact with Sri Lanka: Ministry : The Tribune India
[…] 3 hours ago Govt prohibits exports of remdesivir till COVID situation improves in India Drugs inspectors, other officers directed to verify stocks, […]
1
Maha CM discusses strengthening of health infra with task force | Health
[…] plants, upgrading the number of beds and other medical facilities, besides availability of Remdesivir injections in a meeting held with members of the state COVID-19 task force […] The meeting also discussed how to stop the ”irrational use” of Remdesivir drug, which is in high demand for the treatment of COVID-19 patients […]
0
Maharashtra Covid task force feels ‘lockdown is required’, but decision only after 14 April
theprint.in – Today
[…] with the State Task Force, the chief minister discussed the availability of oxygen & beds, use of Remdesivir, treatment protocols, increase in capacity of facilities, imposition of restrictions & fines fo […]
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Coronavirus latest news: South Africa variant can ‘break through’ Pfizer’s vaccine
[…] 4:46pm India bans export of Covid-19 treatment drug remdesivir India on Sunday banned the export of remdesivir as infections soared to a new daily high and hospitals grappled with increasing demand fo […] Remdesivir, made by US pharma giant Gilead, was one of the first drugs to show relative promise in shortenin […]
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Headlines now: Centre flags gaps in Covid containment measures of 3 states, and other top news
scroll.in – Today
[…] Centre bans export of antiviral drug Remdesivir amid surge in cases: The government said the ban will be in place till the Covid-19 situation i […]
1
Experts demand generic version of drug effective against Covid-19
[…] Among the medicines that have shown to work in Covid-19 are steroids and Remdesivir. The patent owner of Remdesivir, Gilead, had given voluntary licence to six Indian pharmaceuticals […] on rationalising the use of Remedesivir with strict adherence to the guidelines, making multiple Remdesivir stores or Remdesivir banks with strict sales control, and making racketeering of Remdesivir punishable under the Epidemic Act of India […]
1
Decision on Maharashtra lockdown after April 14: State Health Minister | Business Standard News
[…] with the State Task Force, the chief minister discussed the availability of oxygen & beds, use of Remdesivir, treatment protocols, increase in capacity of facilities, imposition of restrictions & fines fo […]
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Enterprise Information | Inventory and Share Market Information – Information by Automobilnews.eu
automobilnews.eu – Today
The Centre has taken the step at a time when the nation is seeing a rising demand for Remdesivir injections attributable to a steep rise in COVID-19 circumstances within the wake of the secon […]
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Nitin Gadkari calls up Sun Pharma’s chief to arrange Remdesivir injections for Nagpur | Indiablooms – First Portal on Digital News Management
[…] today Nitin Gadkari Image: PIB Nitin Gadkari calls up Sun Pharma’s chief to arrange Remdesivir injections for Nagpur India Blooms News Service | @indiablooms | 11 Apr 2021, 07:55 p […] India Blooms News Service | @indiablooms | 11 Apr 2021, 07:55 pm #NitinGadkari, #SunPharma, # Remdesivir, #Nagpur Nagpur/UNI: Union Minister Nitin Gadkari called up Sun Pharma’s chief to arrange fo […] With Maharashtra witnessing a spurt in COVID-19 cases, Remdesivir injections are in high demand in the state. Remdesivir is considered a key anti-viral drug in the fight against COVID-19, especially in adult patient […]
0
Remdesivir Shortage In Nagpur; Gadkari Dials Sun Pharma Chief
Remdesivir [Image: Reuters] Union minister Nitin Gadkari has called up Sun Pharma’s chief to arrange fo […] Union minister Nitin Gadkari has called up Sun Pharma’s chief to arrange for 10,000 injections of Remdesivir in Nagpur in view of a shortage of the medicine here in Maharashtra. Remdesivir is considered a key anti-viral drug in the fight against COVID-19, especially in adult patient […] over phone to inform him about the situation here and appealed to him to make available the Remdesivir injections […]
6
Appropriate decision on lockdown in Maha after April 14: Tope | Politics
[…] with the State Task Force, the chief minister discussed the availability of oxygen & beds, use of Remdesivir, treatment protocols, increase in capacity of facilities, imposition of restrictions & fines fo […]
0
India bans remdesivir exports as COVID-19 cases surge | India News | Al Jazeera
India has banned the export of antiviral drug remdesivir and its active pharmaceutical ingredients as demand rocketed amid a record surge in COVID-1 […] In addition to the remdesivir ban “till the situation improves”, the health ministry said in a statement that manufacturers ha […] The World Health Organization in November issued a conditional recommendation against the use of remdesivir on hospitalised patients, regardless of disease severity, saying there was no evidence that th […]
13
India at third spot on Forbes billionaires’ list : The Tribune India
[…] 2 hours ago Govt prohibits exports of remdesivir till COVID situation improves in India Drugs inspectors, other officers directed to verify stocks, […]
4
India bans export of Covid-19 treatment drug remdesivir
India on Sunday banned the export of remdesivir as infections soared to a new daily high and hospitals grappled with increasing demand for th […] Remdesivir, made by US pharma giant Gilead, was one of the first drugs to show relative promise in shortenin […] generic pharmaceutical producers based in India, Pakistan and Egypt, allowing them to manufacture remdesivir for distribution in 127 mostly low and lower-middle income nations […] firms in India — the world’s biggest producer of generic drugs — are licensed to manufacture remdesivir […]
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Lack of testing, Covid appropriate behaviour not being followed in three states, says Centre
scroll.in – Today
[…] “Similarly, shortage of Remdesivir, Low Molecular Weight Heparin needs urgent attention in Korba District,” the central governmen […]
1
India bans exports of Remdesivir drug as new COVID-19 cases hit another record
thefinancialexpress.com.bd – Today
India on Sunday banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in COVID-1 […] In addition to the Remdesivir ban “till the situation improves”, the health ministry said in a statement that manufacturers ha […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for COVID-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,” Rajesh Tope, health minister of India’ […]
1
Centre bans exports of anti-viral drug Remdesivir
[…] The Centre on Sunday prohibited exports of injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the Covid-19 situation in the country improves […] In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the statement said […] The government has taken the following steps to ensure easy access of hospital and patients to Remdesivir: 1. All domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […]
2
SPL7013 COVID-19 nasal spray virucidal against SARS-CoV-2
starpharma.com – Today
[…] very favourably with the selectivity index against SARS-CoV-2 reported in the literature of 279 for remdesivir and 55 for hydroxychloroquine […]
13
India bans Remdesivir exports as coronavirus rages on; rallies continue | MarketScreener
[…] sixth record rise in seven days, harried relatives of patients made a kilometre-long queue to buy Remdesivir outside a big hospital in the western state of Gujarat, witnesses said […] In addition to the Remdesivir ban “till the situation improves”, the health ministry said that manufacturers had been asked t […] The World Health Organization in November issued a conditional recommendation against the use of Remdesivir in hospitalised patients, saying there was no evidence that the drug improved survival and othe […]
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India bans Remdesivir exports as coronavirus rages on; rallies continue | Health
India on Sunday banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in COVID-1 […] sixth record rise in seven days, harried relatives of patients made a kilometre-long queue to buy Remdesivir outside a big hospital in the western state of Gujarat, witnesses said […] In addition to the Remdesivir ban “till the situation improves”, the health ministry said that manufacturers had been asked t […] The World Health Organization in November issued a conditional recommendation against the use of Remdesivir in hospitalised patients, saying there was no evidence that the drug improved survival and othe […]
0
Maharashtra: Decision on Covid lockdown after 14 April, says health minister Tope
The Maharashtra CM discussed several issues including availability of beds, use of Remdesivir and imposition of restrictions in today’s meeting The worst-hit Covid-19 state has administered over 1 crore vaccine doses state so far
7
India bans export of anti-viral drug Remdesivir amid surge in Covid cases
inquest.org.in – Today
[…] In the order, the government said it has banned the export of Remdesivir injection and Remdesivir active pharmaceutical ingredients (API) till the pandemic situation in the country stabilises […] To ensure more people can get Remdesivir, the government said manufacturers of Remdesivir have been asked to show on their website the details of their stockists and distributors […] of Pharmaceuticals has been in contact with the domestic manufacturers to ramp up the production of Remdesivir,” the government said. The National Clinical Management Protocol for COVID-19 lists Remdesivir as an investigational therapy, where informed and shared decision making is essential […]
5
India bans exports of antiviral drug Remdesivir as COVID-19 cases surge
NEW DELHI: India on Sunday (Apr 11) banned the export of antiviral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in COVID-1 […] In addition to the Remdesivir ban “till the situation improves”, the health ministry said in a statement that manufacturers ha […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for COVID-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,” Rajesh Tope, health minister of India’ […]
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Coronavirus Lockdown India News Live Updates: Covid-19 Cases, Lockdown, Night Curfew Guidelines in Delhi, UP, Maharashtra, MP Today Latest News
indianexpress.com – Today
[…] As Covid-19 cases continued to surge, Centre on Sunday banned the export of anti-viral drug remdesivir in view of increased demand, news agency PTI reported […] easy access of the drug, which is used in treatment of coronavirus, all domestic manufacturers of remdesivir have been requested to display details of their stockists and distributors on their website, th […] 13:52 (IST) 11 APR 2021 Two including nurse arrested for illegal Remdesivir sale The Crime Branch of Pune City police has arrested two persons, including a nurse from […]
3
Covid-appropriate behaviour not being followed in three states: Govt | Business Standard News
[…] Shortage of Remdesivir and low molecular weight Heparin needs urgent attention in Korba, the ministry said […]
1
Govt bans export of Remdesivir: Know all about the drug
[…] What is Remdesivir? Remdesivir is an investigational antiviral drug to fight Sars-cov 2, the virus that causes Covid-19 […] How did Remdesivir come into use? FDA had to issue an emergency use authorisation of Remdesivir to give doctors access to the medication outside of an investigational (clinical trial) setting […]
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COVID appropriate behaviour not being followed in 50 most-affected districts in 3 states: Govt | Health
[…] Shortage of Remdesivir and low molecular weight Heparin needs urgent attention in Korba, the ministry said […]
0
Govt prohibits exports of remdesivir till COVID situation improves in India | India News,
indianexpress.com – Today
In view of increased demand for remdesivir due to a surge in COVID-19 cases, the Centre on Sunday said the export of the antiviral injectio […] which is used in treatment of coronavirus, to hospitals and patients, all domestic manufacturers of remdesivir have been advised to display on their website details of their stockists and distributors, th […] This has led to a sudden spike in demand for remdesivir injection used in treatment of COVID patients,” the ministry said […] “In light of the above, Government of India has prohibited the exports of remdesivir injection and remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” it said […]
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Mathura’s Banke Bihari temple issues new guidelines amid surge in COVID-19 cases | India News • eeKPe News
news.eekpe.com – Today
[…] As India experiences a second wave of novel coronavirus infections, the demand for anti-viral drug Remdesivir has surged too. The Centre on… Read more India Bans Export Of Anti-Viral Drug Remdesivir Amid Surge In… INDIA eekpe – April 11, 2021 0 <!– –>7 Indian corporations are producing Remdesivir beneath voluntary licensing settlement with Gilead Sciences (File)New Delhi: India has banne […]
0
Doctors continue debate over ivermectin for COVID-19
[…] that only 16 deaths have been reported involving ivermectin, compared to much higher totals for remdesivir, which is used to treat COVID-19 symptoms, as well as COVID-19 vaccines […]
24
Can natural antioxidants help fight new GI symptoms in Covid patients?
yespunjab.com – Today
[…] (Agency) Covid Spike: India Prohibits Export Of Remdesivir – Advertisement – ShareFacebook Twitter Pinterest WhatsApp Linkedin Telegram Yes Punjab – TO […]
1
Covid spike: India prohibits export of remdesivir
[…] trend, the Ministry said: “There is a potential of further increase in demand of injection remdesivir and remdesivir active pharmaceutical ingredients (API) in the coming days […] of the above increasing Covid cases, Government of India has prohibited the exports of injection remdesivir and remdesivir active pharmaceutical ingredients (API) till the situation improves […] ” Govt of India prohibited exports of injection remdesivir and active pharmaceutical ingredients Seven Indian companies are producing injection remdesivir under voluntary licensing agreement with Gilead Sciences, US […]
0
India bans exports of anti-viral drug Remdesivir as Covid-19 cases surge
kathmandupost.com – Today
India said on Sunday it had banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients after a record spike in Covid-19 cases sent deman […] “In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the health ministry said in a […]
0
India bans exports of Remdesivir drug as new Covid-19 cases hit another record, South Asia News & Top Stories
NEW DELHI (REUTERS) – India on Sunday (April 11) banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in Covid-1 […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for Covid-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,”Mr Rajesh Tope, health minister of India’ […]
3
India bans exports of Remdesivir drug as new Covid-19 cases hit another record
NEW DELHI (REUTERS) – India on Sunday (April 11) banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in Covid-1 […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for Covid-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,”Mr Rajesh Tope, health minister of India’ […]
1
Centre prohibits export of Injection Remdesivir in view of surge in COVID cases
[…] This has led to a sudden spike in demand for Injection Remdesivir used in the treatment of COVID patients […] In light of the above, the Government of India has prohibited the export of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves […] Government of India has taken the following steps to ensure easy access of hospital and patients to Remdesivir: All domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […]
1
Vaccine universalisation, vaccine nationalism need of the hour: AAP leader Chadha writes to PM | Politics
[…] for all and taking steps like prohibiting COVID medicine export as it has today banned export of remdesivir injections,” he said […]
0
India bans export of Remdesivir amid rising Covid-19 cases
newsvibesofindia.com – Today
New Delhi (NVI): India has prohibited exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the COVID-19 situation improves, as the countr […] It said that there is a potential of further increase in the demand of Injection Remdesivir in the coming days. At present, seven Indian companies are producing Injection Remdesivir under voluntary licensing agreement with M/s […] In light of the above, India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves, the Ministry said […]
0
Maharashtra: Thane Covid centre patients shifted over oxygen concerns | Business Standard News
[…] as officer in charge to coordinate the purchase, storage and distribution of medical oxygen gas and Remdesivir injections, a release by civic spokesperson Sandeep Malavali said […]
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India bans exports of Remdesivir drug as new COVID-19 cases hit another record | MarketScreener
[…] In addition to the Remdesivir ban “till the situation improves”, the health ministry said in a statement that manufacturers ha […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for COVID-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,” Rajesh Tope, health minister of India’ […]
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Maha: Thane COVID centre patients shifted over oxygen concerns | Health
[…] as officer in charge to coordinate the purchase, storage and distribution of medical oxygen gas and Remdesivir injections, a release by civic spokesperson Sandeep Malavali said […]
0
India Bans Exports of Antiviral Drug Remdesivir as COVID-19 Cases Surge
science.thewire.in – Today
Seven Indian companies have licensed the drug from Gilead Sciences, with an installed capacity of about 3.9 million units per month.
2
India bans exports of Remdesivir drug as new COVID-19 cases hit another record | Health
India on Sunday banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in COVID-1 […] In addition to the Remdesivir ban “till the situation improves”, the health ministry said in a statement that manufacturers ha […] media posts on Sunday showed large queues of people in the western state of Gujarat waiting to buy Remdesivir injections for COVID-19 patients. “Every day the central government is providing 50,000 Remdesivir injections but all of them are getting consumed,” Rajesh Tope, health minister of India’ […]
0
Amidst sharp rise in COVID-19 cases, India bans export of Remdesivir; its active pharmaceutical ingredients
asianews.press – Today
[…] As a result, it has led to a sudden spike in demand for Injection Remdesivir used in the treatment of COVID patients and the potential for a further increase in this demand i […] The Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) “till the situation improves in the country […] India govt has taken the following steps to ensure easy access of hospital and patients to Remdesivir: All domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […]
1
No export of Remdesivir till COVID situation improves in India: Govt
New Delhi: In view of increased demand for Remdesivir due to a surge in COVID-19 cases, the Centre on Sunday said the export of the antiviral injectio […] which is used in treatment of coronavirus, to hospitals and patients, all domestic manufacturers of Remdesivir have been advised to display on their website details of their stockists and distributors, th […] This has led to a sudden spike in demand for Remdesivir injection used in treatment of COVID patients,” the ministry said […] “In light of the above, Government of India has prohibited the exports of remdesivir injection and remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” it said […]
0
India halts export of key Covid drug Remdesivir as cases rise across country
theprint.in – Today
Text Size: A- A+ New Delhi: The Centre on Sunday prohibited exports of injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the Covid-19 situation in the country improves. Remdesivir is considered a key anti-viral drug in the fight against Covid-19 […] addition, the government has taken three steps to ensure easy access of hospitals and patients to Remdesivir. All domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […]
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Enterprise Information | Inventory and Share Market Information – Information by Automobilnews.eu
automobilnews.eu – Today
“Export of injection Remdesivir and Remdesivir Energetic Pharmaceutical Components (API) prohibited until the COVID-19 state of affairs within the […]
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As coronavirus cases spike, Indore’s health infrastructure gets stretched | Business Standard News
[…] uploading videos and messages on social media about shortage of beds and key medicines like Remdesivir […] He said Remdesivir consignments were coming in at present and their distribution was taking place as per guidelines […] “Doctors have been told to give Remdesivir injections only to those who absolutely need it,” Satya said […]
2
India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge
India on Sunday banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients as demand rocketed due to a record surge in COVID-1 […] sixth record rise in seven days, harried relatives of patients made a kilometre-long queue to buy Remdesivir outside a big hospital in the western state of Gujarat, witnesses said […] In addition to the Remdesivir ban “till the situation improves,” the health ministry said that manufacturers had been asked t […] The World Health Organization in November issued a conditional recommendation against the use of Remdesivir in hospitalized patients, saying there was no evidence that the drug improved survival and othe […]
10
Covid-19: India bans export of Remdesivir injection, API
India today prohibited the export of Remdesivir injection, which is used to treat Covid patients, and also Remdesivir Active Pharmaceutical Ingredients (API), amidst a surge in coronavirus cases in the country […] “This has led to a sudden spike in the demand for injection Remdesivir used in treatment of Covid patients […] Seven Indian companies are producing the Remdesivir injection under voluntary licensing agreement with M/S Gilead Sciences of the USA […]
3
Maharashtra likely to announce 15-day lockdown after weekend curbs, marginal drop in Covid-19 cases after night curfew
[…] Other suggestions by Fadnavis like the early report of tests, availability of Remdesivir and oxygen for treatment will also be considered […]
1
“For God’s Sake, Get Vaccine, Drugs”: Top Mumbai Doctor’s Desperate Appeal
[…] The hospital was not only short of vaccines but also life-saving drugs like Remdesivir, said Dr Jalil Parkar, a pulmonary consultant with the hospital […] There is a shortage of Remdesivir, there is shortage of Tosilizubam […] “My earnest request for god’s sake please see to it that Remdesivir, Tosilizubam, vaccination — they are available […]
0
COVID-19: Centre bans exports of anti-viral drug Remdesivir till situation in India improves
COVID-19: Centre bans exports of anti-viral drug Remdesivir till situation in India improves India’s sudden spike in COVID-19 cases has led to an increase i […] Zee Media Updated: Apr 11, 2021, 06:29 PM IST The Centre on Sunday prohibited exports of injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the Covid-19 situation in the country improves […] data on deaths In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the statement said […]
1
8k Remdesivir vials have arrived: Madhya Pradesh official as cases surge
[…] (Representational image: IE) Amid a surge in coronavirus cases and a clamour for Remdesivir, a drug considered useful in the treatment of the infection, a senior Madhya Pradesh official o […]
1
India bans Remdesivir exports till COVID surge abates
Seven Indian companies producing Remdesivir injections under voluntary licensing agreement with US-based Gilead Sciences have an installed capacity of about 38.80 lakh units per month
2
Government Halts Export Of Remdesivir Till COVID-19 Situation Improves
[…] The Government of India said: “Export of injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) prohibited till the COVID-19 situation in the countr […] of Pharmaceuticals has been in contact with the domestic manufacturers to ramp up the production of Remdesivir in India. Notably, there are seven Indian companies that are currently producing injection Remdesivir under voluntary licensing agreement with M/s Gilead Sciences, USA […]
6
Export of anti-viral drug remdesivir prohibited in view of increased demand due to surge in COVID-19 cases: Centre. | Newsalert
Export of anti-viral drug remdesivir prohibited in view of increased demand due to surge in COVID-19 cases: Centre. PTI | New Delhi | Updated: 11-04-2021 18:11 IST | Created: 11-04-2021 18:11 IST Export of anti-viral drug remdesivir prohibited in view of increased demand due to surge in COVID-19 cases: Centre. (This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.) POST / READ COMMENTS Country India Share
0
Clinical Research Forum Presents Moderna and Pfizer with Award for Extraordinary Impact on Health | NEWS-Line for Healthcare Professionals
[…] Hospital; Margaret Lippincott, MD, Instructor in Medicine, Massachusetts General Hospital · Remdesivir in COVID 19 – John Beigel, MD, Associate Director for Clinical Research, National Institute o […]
1
Centre bans export of Remdesivir amid crunch, eases access of Covid patients to anti-viral drug – Coronavirus Outbreak News
[…] being used in the treatment of Covid-19 patients, the Centre has prohibited the export of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) […] In a press note on Sunday, the Centre prohibited exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API). A number of companies in India produce Injection Remdesivir under a voluntary licensing agreement with US pharma giant Gilead Sciences […]
3
For God’s Sake, Get Vaccine, Drugs: Top Mumbai Doctor’s Desperate Appeal
[…] The hospital was not only short of vaccines but also life-saving drugs like Remdesivir, said Dr Jalil Parkar, a pulmonary consultant with the hospital […] There is a shortage of Remdesivir, there is shortage of Tosilizubam […] “My earnest request for god’s sake please see to it that Remdesivir, Tosilizubam, vaccination — they are available […]
16
Government bans export of Remdesivir till Covid-19 situation improves
economictimes.indiatimes.com – Today
[…] In an order, the government said it has banned export of Remdesivir injection and Remdesivir active pharmaceutical ingredients (API) till the pandemic situation in the country stabilises […] the government has also taken a few steps to ensure easy access of hospital and patients to Remdesivir. These steps are: – All domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […]
6
COVID-19: India bans export of Remdesivir drug, injection as coronavirus cases surge | India News
zeenews.india.com – Today
CORONAVIRUS COVID-19: India bans export of Remdesivir drug, injection as coronavirus cases surge The Centre banned the export of Remdesivir and its active pharmaceutical ingredients as the demand for anti-viral drug Remdesivir has surged […] As India experiences a second wave of novel coronavirus infections, the demand for anti-viral drug Remdesivir has surged too. The Centre on Sunday (April 11, 2021) banned the export of Remdesivir and its active pharmaceutical ingredients […]
16
India bans export of Remdesivir, its ingredients till COVID situation improves | Coronavirus News | Inshorts
inshorts.com – Today
india has banned the export of injection remdesivir and its active pharmaceutical ingredients api till the coronavirus situation in the country improves the centre said on sunday theres potential for further increase in demand for remdesivir in the coming days the government said adding that the …
0
Centre Bans Export of Remdesivir and Its Active Ingredients till Covid Crisis Eases in India
The Centre on Sunday prohibited the export of Remdesivir injection and its active pharmaceutical ingredients (API) till the pandemic situation arising ou […] The decision has been taken to ensure easy access of Remdesivir to infected patients and hospitals providing treating against the virus […] Several hospitals have complained of shortage of Remdesivir, considered a key anti-viral drug in the fight against COVID-19, especially in adult patients wit […] other steps to bring the situation under control, including advising all domestic manufactures of Remdesivir to display on their website, details of their stockists and distributors to facilitate access t […]
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India bans export of Remdesivir injection amid surge in Covid cases | India News – Times of India
NEW DELHI: India on Sunday banned the export of Remdesivir injection till the Covid-19 situation improves in the country […] The government in a statement said that all domestic manufactures of Remdesivir have been advised to display on their website, details of their stockists/distributors t […] of Pharmaceuticals has been in contact with the domestic manufacturers to ramp up the production of Remdesivir […] The alarming spike in Covid cases in the country has led to a sudden increase in demand for the Remdesivir injection used in treating Covid patients […]
0
India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge
NEW DELHI: India said on Sunday it had banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients after a record spike in COVID-19 cases sent deman […] “In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the health ministry said in a […]
0
India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge | Reuters
[…] 1 MIN READ NEW DELHI (Reuters) – India said on Sunday it had banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients after a record spike in COVID-19 cases sent deman […] “In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the health ministry said in a […]
2
India bans export of Remdesivir injection amid surge in Covid cases | India News – Times of India
timesofindia.indiatimes.com – Today
India News: NEW DELHI: India on Sunday banned the export of Remdesivir injection till the Covid-19 situation improves in the country.
19
No lockdown in Madhya Pradesh, only ‘corona curfew’, says CM | Business Standard News
[…] We have received 4,000 injections of Remdesivir (the key anti-viral drug) and would be getting 5,000 more today […]
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Coronavirus: Centre bans export of antiviral drug Remdesivir amid surge in cases
scroll.in – Today
The Centre on Sunday banned the export of antiviral drug Remdesivir indefinitely, in view of the rising coronavirus cases in the country, ANI reported […] The government said the ban, which covers Remdesivir injections and Remdesivir active pharmaceutical ingredients, will be lifted only after there is an improvement in th […] Remdesivir is considered a key drug in combating Covid-19, especially in adult patients with sever […]
1
Gilead Sciences : India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge | MarketScreener
“In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the health ministry said in a statement. Seven Indian companies have licensed the drug from Gilead Sciences, with an installed capacity of about 3.9 million units per month. (Reporting by Krishna N. Das and Devjyot Ghoshal; Editing by Susan Fenton)
0
Centre Prohibits Export of Remdesivir till COVID-19 Situation in Country Improves
Centre Prohibits Export of Remdesivir till COVID-19 Situation in Country Improves…
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India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge
mumbaimirror.indiatimes.com – Today
India bans exports of anti-viral drug Remdesivir as COVID-19 cases surge Reuters / Updated: Apr 11, 2021, 17:50 IST Representational Image […] Photo: BCCL New Delhi: India said on Sunday it had banned the export of anti-viral drug Remdesivir and its active pharmaceutical ingredients after a record spike in COVID-19 cases sent deman […] “In light of the above, Government of India has prohibited the exports of Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the situation improves,” the health ministry said in a […]
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Centre prohibits export of Remdesivir & its API till COVID-19 situation improves in India
With several states complaining of shortage of Remdesivir injections – which is used in COVID-19 treatment, the Centre on Sunday, has banned the export of Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) till the COVID-19 situation in the country improves […] READ | Remdesivir shortage in Nagpur; Union Minister Nitin Gadkari dials Sun Pharma chief Govt bans export of Remdesivir Additionally, Centre has taken the following steps to streamline Remdesivir supply: All domestic manufactures of Remdesivir have been advised to display on their website […]
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Govt suspends export of Remdesivir till coronavirus situation improves | Business Standard News
The union government on Sunday suspended the export of Remdesivir injections and Remdesivir Active Pharmaceutical Ingredients (API) till the coronavirus situation improves in the country […] “The current situation has led to a sudden spike in demand for Remdesivir injection used in treatment of Covid patients […] In addition, the government has taken the steps to ensure easy access of hospital and patients to Remdesivir All domestic manufactures of Remdesivir have been advised to display on their website, details of their stock lists or distributors t […]
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India bans export of Remdesivir drug, injection till Covid situation improves
“Export of injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) prohibited till the COVID-19 situation in the countr […] This has led to a sudden spike in demand for Injection Remdesivir used in treatment of COVID patients. There is a potential of a further increase in demand for Remdesivir injection in the coming days,” the Centre said in a statement […] of Pharmaceuticals has been in contact with domestic manufacturers to ramp up the production of Remdesivir, it further stated. In its fresh order, it said that all domestic manufactures of Remdesivir advised to display on their website, details of their stockists/distributors to facilitate acces […]
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No lockdown in MP, only ‘corona curfew’: Chouhan | Health
[…] We have received 4,000 injections of Remdesivir (the key anti-viral drug) and would be getting 5,000 more today […]
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India Bans Export Of Anti-Viral Drug Remdesivir Amid Surge In Covid Cases
[…] In an order, the government said it has banned export of Remdesivir injection and Remdesivir active pharmaceutical ingredients (API) till the pandemic situation in the country stabilises […] To ensure more people can get Remdesivir, the government said manufactures of Remdesivir have been asked to show on their website the details of their stockists and distributors […] of Pharmaceuticals has been in contact with the domestic manufacturers to ramp up the production of Remdesivir,” the government said. The National Clinical Management Protocol for COVID-19 lists Remdesivir as an investigational therapy, where informed and shared decision making is essential […]
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Remdesivir injections and Favipiravir tablets vanish from UP’s Prayagraj medicine shops | Allahabad News
dlsnewsindia.com – Today
PRAYAGRAJ: The Remdesivir injection and Favipiravir tablets seem to have vanished from the city-based medicine market wit […] at Leader road dealing wholesale medicine market claimed that there was an acute shortage of Remdesivir injection and Favipiravir tablets […] UP Chemist & Druggist Federation admitted to TOI that there has been an acute shortage of Remdesivir injection and Favipiravir tablets in markets and we have been demanding from concerne […] “ I have made calls to my relatives to arrange Remdesivir injection after seeing its acute crisis in city” said Ashutosh who arrived Leader road medicin […]
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NEWS HIGHLIGHTS FROM WESTERN REGION AT 5 pm. | Law-Order
[…] BOM2 MH-REMDESIVIR-CONTROL ROOMS Maha to set up control rooms for smooth supply of Remdesivir Mumbai: The Maharashtra government has decided to set up district-level control rooms to ensur […] government has decided to set up district-level control rooms to ensure smooth supply of Remdesivir injections and prevent hoarding and black-marketing of the drug, officials said on Sunday […]
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Coronavirus update: Latest Covid-19 vaccine and world news
[…] India has banned the export of anti-viral drug remdesivir and its active pharmaceutical ingredients following a rise in coronavirus cases, a statement fro […] The ban would apply to Injection Remdesivir and Remdesivir Active Pharmaceutical Ingredients (API) until the Covid-19 situation in the country improves, th […] ministry said, adding that this rise has led to a sudden spike in demand for the anti-viral drug remdesivir and its active pharmaceutical ingredients used in the treatment of coronavirus patients […]
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Business & Financial News, U.S & International Breaking News | Reuters
[…] Carnival-loving, eloquent Soeder wants to be Germany’s first Bavarian chancellor 2h ago India bans Remdesivir exports as coronavirus rages on; rallies continue 2h ago Pacific island devotees of Prince Phili […]
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AAP slams BJP’s ‘free Remdesivir distribution’ in Surat; Guj CM says ‘not from govt stock’
Last Updated: 11th April, 2021 16:37 IST AAP Slams BJP’s ‘free Remdesivir Distribution’ In Surat; Guj CM Says ‘not From Govt Stock’ Slamming BJP’s Gujarat unit over Remdesivir injection hoarding, AAP said that the BJP had taken PM Modi’s message of  “converting disasters o […] Currently, Gujarat’s neighbouring state Maharashtra too is facing an acute Remdesivir shortage. READ | Maharashtra to set up control rooms for smooth supply of Remdesivir amid COVID crisis “About Surat, C R Paatil has arranged for 5,000 Remdesivir injections […]
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FREE Coronavirus Awareness Training – Free E-Learning Course
[…] trials are looking at the potential use of two HIV drugs as well as another antiviral called Remdesivir that was developed to tackle haemorrhagic fevers including Ebola […]
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