Should You Microdose to Treat Depression

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The following article is written by . Author of the book, Unstoppable: A 90-Day Plan to Biohack Your Mind and Body for Success. Buy it now from Amazon | Barnes & Noble | iBooks | IndieBound. And be sure to order The Unstoppable Journal, the only journal of its kind based on , and biohacking to help you reach your goals.

If you asked 100 people about psychedelics, you’d most likely get 100 opinions based on their firsthand experience, strong condemnation or stories from their adventures at Woodstock in the ’60s. No matter what people might know or think they know about psychedelics, the 40-year moratorium that closed down related research in the ’70s is now coming to an end. Psychiatrists are beginning to realize that strategic, supervised use of these psychopharmacological drugs is helping people with mental disorders including obsessive-compulsive disorder, post-traumatic stress disorder, alcoholism, depression and cluster headaches. Still, are there enough scientific studies to warrant the use of these drugs in mainstream society?

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I’ll admit that talk of psychedelic therapy to treat depression makes me nervous. In researching my book, Unstoppable, I looked at other key triggers that can mimic psychological disorders like depression and , such as inflammation, nutritional deficiencies, hormonal changes, side effects from medications, gut imbalances and food sensitivities. The reality is, depression is complex. What works for one may not work for another. Any successful treatment must first identify the root cause of one’s depression successfully, which can be a complex process if not done under the right medical care. A psychedelic treatment isn’t suddenly going to fix a nutritional deficiency, for example, but it may help target other symptoms and behaviors that correspond with depression. This is why it was critical to set my own biases aside and speak to an expert.

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I was fortunate enough to interview Dr. Domenick J. Sportelli, who is board-certified by the American Board of Neurology and for General Psychiatry and fellowship-trained and Board Certified in Child and Adolescent Psychiatry. He also specializes in human behavior and psychopharmacology. I wanted to get the most current information on the use of psychedelics in treatment for depression, anxiety and PTSD, so I first asked him first to clarify what psychedelics were.

“The term ‘psychedelic substance’ refers to an exogenous substance [derived outside the body] that, when taken into the body in various ways, physiologically, neurologically and psychologically manifest an internal personal experience of altered states of consciousness,” he explains. “This includes perceptual distortions, hallucinations, synesthesia [a mixing of the senses], altered sense of time and space, as well as potentially inducing what researchers call a ‘mystical experience’ — a sense of oneness, of noetic experience and an undefinable but profoundly spiritual quality.”

Is there enough evidence to support psychedelic therapy? 

Sportelli wants to make clear that the most researched psychedelics — LSD, psilocybin (mushrooms), peyote, MDMA, DMT and ketamine — have different mechanisms of action and even induce subtle, subjective experiential differences. Although each is grouped under the term “psychedelics,” they are quite disparate.

Dr. Sportelli is cautiously optimistic about the multitudes of large-scale, university-based testing and prior research compiled decades ago, but worries about the abiliity to circumvent bureaucracy and conduct safe, credible and substantial testing today. He does add that recent testing of psilocybin, LSD, ketamine and MDMA in particular has generated cause for optimism, and that they will likely have a place not only in continued, diverse research design and protocol, but eventually in therapeutic use.

What types of depression can psychedelics treat?

If we were to look at the onset of most mental illnesses, the majority start to become evident between the ages of 11 and 24, according to the National Institute of Health. With only 42 percent of people getting treatment, most typically do not seek out assistance until a secondary mental illness occurs several years later.

When asked how broadly psychedelics might be able to help treat people with depression, Sportelli concedes that, “Unfortunately, research hasn’t determined the level of scientific data to specify the type of depression or mood disorder that psychedelic therapy will benefit.” But he does add that research and data are beginning to show statistically significant improvements in mood, reduced anxiety, change in positive personality traits over time, the possibility of reducing addictive behaviors, reduction in suicidal tendencies and increased personal insight.

Do psychedelics treat the symptoms or the cause?

According to Dr. Sportelli, depression stems from a mix of genetic, biological, neurological, psychological and sociological factors. Recent research has demonstrated how the chemical breakdown of psilocybins closely resembles that of serotonin, and indicated the promising interplay of select hormone transmission. Dr. Sportelli stresses the critical role that these drugs might offer in mood disorders is at the forefront of the pharmaceutical quest for treatment.

“We have never seen substances like these that can potentially change the way that we look at our life and change perspective with lasting results,” he says, noting that they might be able to help “supercharge psychotherapy.”

Is this ultimately a recommend treatment, and where does one turn for it?

“At this time, in the U.S., I would only recommend this treatment be a part of, and under the close supervision of, a university-based IRB [Institutional Review Board]-monitored clinical trial,” Sportelli emphasizes. Before any psychiatric treatment, Dr. Sportelli also recommends a full medical and neurological evaluation to rule out any of the multitudes of medical circumstances that can manifest as a primary mood disorder, and reiterates that significant and often profoundly adverse outcomes associated with such powerful, mind-altering chemicals need to be weighed further as well. That’s why, as part of any regulated trial, all the necessary medical workups would be completed before participation.

Is the stigma around psychedelic therapy warranted? 

Sportelli acknowledges that there is a safety concern associated with psychedelics, and does not condone their recreational or illict use. But he does believe that regulated clinical trials, judicious and ethical research methodology and the progression for therapeutic intervention should not be overlook based on previous stigma and possible misclassification.

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I’ve never been one to throw the baby out with the bathwater. After interviewing Dr. Sportelli, I hold hope for the future, but also a concern for those who may seek out this kind of treatment without an accurate medical diagnosis. My number-one hesitation remains — that is we simply do not have the studies to show which types of depression psychedelic therapy successfully treats, which may result in people attempting to use a hammer when in fact they need a nail.

Either way, if you are to venture into this arena, find someone who specializes in it. The risk of going it alone could come at too a high price.

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Number of Children Who Visit ER Due to Suicidal Thoughts Is Rising at a Shocking Pace

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More and more kids are visiting the emergency room for both attempted suicide and suicidal thoughts. According to a new study published on Monday, the number of suicide-related ER visits for children and teens ages five to 18 has nearly doubled since 2007, up from 580,000 to almost 1.2 million in 2015.

“The numbers are very alarming,” Dr. Brett Burstein, lead study author and a pediatric ER doctor at Montreal Children’s Hospital of McGill University Health Centre, told FOX 8, adding, “It also represents a larger percentage of all pediatric emergency department visits. Where suicidal behavior among the pediatric population was just 2 percent of all visits, that’s now up to 3.5 percent.”

The study, which appeared in JAMA Pediatrics, used data from the annual National Hospital Ambulatory Medical Care Survey run by the U.S. Centers for Disease Control and Prevention. Researchers analyzed children and teens from 300 emergency rooms across the country who were diagnosed with suicidal thoughts or suicide attempts.

In addition to the rising rate of visits, they found that the average age admitted was 13 years old and that almost half of the visits (43 percent) were for children between the ages of five and 11.

This came on the heels of a similar study published in the American Academy of Pediatrics’ journal, Pediatrics, which found that the number of young people visiting the emergency room due to “psychiatric reasons” between 2011 and 2015 was up nearly 28 percent. And in March, another national study revealed that the rate of depression among children and teens had increased over 60 percent since 2009.

The results have many medical professionals calling for improved mental healthcare for children moving forward. In Monday’s research letter, study authors explain that there is “a critical need to augment community mental health resources, ED physician preparedness, and post-emergency department risk reduction initiatives to decrease the burden of suicide among children.”

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Source: https://www.fatherly.com/news/number-emergency-room-visits-kids-suicide-doubled/

 

 

 

Stress Hormone” Cortisol Linked to Early Toll on Thinking Ability – Karen Weintraub

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The stresses of everyday life may start taking a toll on the brain in relatively early middle age, new research shows. The study of more than 2,000 people, most of them in their 40s, found those with the highest levels of the stress-related hormone cortisol performed worse on tests of memory, organization, visual perception and attention. Higher cortisol levels, measured in subjects’ blood, were also found to be associated with physical changes in the brain that are often seen as precursors to Alzheimer’s disease and other forms of dementia, according to the study published Wednesday in Neurology………

Read more: https://www.scientificamerican.com/article/ldquo-stress-hormone-rdquo-cortisol-linked-to-early-toll-on-thinking-ability/

 

 

 

 

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Prisoner, Wife Allegedly Commit Suicide During Visiting Hours – ASEAN Plus

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The Lumajang Police have reported that a prisoner and his wife allegedly committed suicide during visiting hours at the Lumajang Penitentiary Class II-B in East Java on Friday.

The Lumajang Police’s criminal investigation unit head, AKP Hasran, said the prisoner, 30, and his wife, 18, died after drinking the same beverage.

“The wife and the prisoner’s mother brought him a meal that had been checked by penitentiary officers,” Hasran said on Friday.

He explained that, according to information gathered, the prisoner asked for plastic cups from the canteen officer. He then poured the beverage into the plastic cups for himself and his wife.

“After a while, as they were hugging each other, they both laid down and experienced shortness of breath,” he said.

The penitentiary officers and several prisoners brought them to the polyclinic but they died shortly afterwards, Hasran added.

The police took the bottle and the plastic cups used by the victims to the East Java Police forensic laboratory in Surabaya for examination.

The police have also requested Lumajang Hospital to perform an autopsy on the bodies. – The Jakarta Post/Asia News Network

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