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The objective of the current study was to compare the responses to different ex vivo immunogenic challenges between immune cells derived from metabolically healthy subjects with obesity and subjects with obesity and type 2 diabetes.
Our results suggest that compared with obese individuals metabolically healthy individuals with obesity and type 2 diabetes have an impaired neutrophil function and T cell response on challenge despite having a T cell population expressing more activation markers which may be partly responsible for the increased prevalence of infection reported in this population.
We demonstrated for the first time that compared with obese individuals metabolically healthy individuals with obesity and type 2 diabetes have an impaired T cell response after challenge despite having a T cell population expressing more activation markers.
Neutrophil function was also altered in subjects with obesity and type 2 diabetes with a lower stimulation index poststimulation compared with metabolically healthy individuals with obesity.
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