A Brain Expert Shares His 7 Hard Rules For Boosting Memory and Fighting Off Dementia

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The average human brain shrinks by approximately 5% per decade after the age of 40. This can have a major impact on memory and focus. What’s more, brain disorders are on the rise. In 2020, 54 million people worldwide had Alzheimer’s disease or other dementias, and that number is expected to grow.

But serious mental decline doesn’t have to be an inevitable part of aging. In fact, certain lifestyle factors have a greater impact than your genes do on whether you’ll develop memory-related diseases. As a neuroscience researcher, here are seven hard rules I live by to keep my brain sharp and fight off dementia.

1. Keep blood pressure and cholesterol levels in check

Your heart beats roughly 115,000 times a day, and with every beat, it sends about 20% of the oxygen in your body to your brain. High blood pressure can weaken your heart muscle, and is one of the leading causes of strokes. Ideally, your blood pressure should be no higher than 120/80.

Cholesterol is critical to your brain and nervous system health, too. The American Heart Association recommends getting your cholesterol levels measured every four to six years.

2. Manage sugar levels

Blood sugar is the primary fuel of the brain. Not enough of it, and you have no energy; too much, and you can destroy blood vessels and tissue, leading to premature aging and cardiovascular disease.

Keep in mind that sugar isn’t enemy, excess sugar is. It’s easy for grams of sugar to add up, even if you think you’re being careful — and usually, sugar will sneak in through packaged foods.

Where is the sugar hidden? Look for these in the ingredients list:

  • Dextrose
  • Fructose
  • Galactose
  • Glucose
  • Lactose
  • Maltose
  • Sucrose

And be wary of any product that includes syrup, such as agave nectar syrup or high-fructose corn syrup.

3. Get quality sleep

Studies show that people with untreated sleep apnea raise their risk of memory loss by an average of 10 years before the general population. For most people, a healthy brain needs somewhere between seven and nine hours of sleep a night.

My tips for memory-boosting, immune-enhancing sleep:

  • Keep a consistent bedtime and wake-up schedule.
  • Turn off devices one hour before bedtime.
  • Do something relaxing before bedtime, like listening to soft music or doing mindful breathing exercises.
  • Go outside and get in natural sunlight as soon as you can after waking up.

4. Eat a nutritious diet

One way I keep things simple is to have most, if not all, of these items in my grocery cart:

  • Fatty fish like salmon
  • Avocados
  • Nuts
  • Blueberries
  • Cruciferous veggies like arugula, broccoli, Brussels sprouts and collard greens

When food shopping, I ask myself three questions to help determine whether something is good for my brain:

1. Will it spoil? In many cases, perishable is a good thing. The additives and preservatives that keep food from spoiling wreak havoc on your gut bacteria.

2. Are there tons of ingredients in that packaged food? And for that matter, can you pronounce the ingredients? Or does it look like the makings of a chemical experiment? Also avoid anything where sugar is one of the first few ingredients.

3. Do you see a rainbow on your plate? The chemicals that give fruits and vegetables their vibrant colors help boost brain health.

5. Don’t smoke (and avoid secondhand and thirdhand smoke)

Smokers have a 30% higher risk of developing dementia than non-smokers. They also put those around them at risk: Secondhand smoke contains 7,000 chemicals — and at least 70 of them can cause cancer.

Then there’s thirdhand smoke, which is not actually smoke. It’s the residue of cigarette smoke that creates the telltale smell on clothing or in a room. That residue alone can emit chemicals that are toxic to the brain.

6. Make social connections

In a recent study, people over the age of 55 who regularly participated in dinner parties or other social events had a lower risk of losing their memory. But it wasn’t because of what they ate, it was the effect of the repeated social connection.

To lessen isolation and loneliness, you can also boost brain chemicals like serotonin and endorphins by performing small acts of kindness:

  • Wish others well or check in with somebody.
  • Give a compliment without expecting anything in return.
  • Make a phone call to somebody you don’t usually reach out to.

7. Continuously learn new skills

Maintaining a strong memory is not all about brain games like Sudoku, Wordle and crossword puzzles.

Learning skills and acquiring information are much more effective ways to make new connections in the brain. The more connections you make, the more likely you are to retain and even enhance your memory.

When you think about learning something new, approach it the way you would with fitness training. You want to work out different muscles on different days. The same goes for the brain.

Over the course of this week, try cross-training your brain by mixing mental activities (learning a new language or reading a book) and physical learning activities (playing tennis or soccer) .

By: Marc Milstein

Marc Milstein, PhD, is a brain health expert and author of “The Age-Proof Brain: New Strategies to Improve Memory, Protect Immunity, and Fight Off Dementia.” He earned both his PhD in Biological Chemistry and his Bachelor of Science in Molecular, Cellular, and Developmental Biology from UCLA, and has conducted research on genetics, cancer biology and neuroscience. Follow him on Twitter and Instagram.

Source: A brain expert shares his 7 ‘hard rules’ for boosting memory and fighting off dementia

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What Is Seed Cycling? Experts Weigh In On Eating Seeds For Fertility, Hormone Balance

If you’re trying to get pregnant, you’ve likely come across the practice of seed cycling, which involves eating specific seeds in the hopes of boosting fertility.

Of course, the irresistibly salty crunch of sunflower or pumpkin seeds makes them great snacks. But could those seeds actually do more for your health or even help balance hormone levels?

While seeds may be nutritious and tasty, experts are skeptical that seed cycling can produce real results. Here’s what you should know before you try it — and why you might want to go slow when adding seeds to your diet.

What is seed cycling?

The basic premise of seed cycling is that eating certain types of ground seeds (pumpkin seeds, flax seeds, sesame seeds and sunflower seeds) every day at different points in your menstrual cycle can affect hormone levels. And seed cycling proponents claim the practice may increase fertility and ease PMS symptoms.

“The theory — emphasis on the word theory — of seed cycling is that compounds called lignans can stimulate estrogen activity,” Whitney Linsenmeyer, a registered dietitian, spokesperson for the Academy of Nutrition and Dietetics and assistant professor at Saint Louis University, told TODAY.

Lignans are a set of compounds found in seeds (especially flax seeds) that can have anti-inflammatory properties, TODAY explained previously. And there is some limited research, like this 2011 study in mice, that suggests lignans can interact with estrogen and even produce estrogen-like effects.

Other components in seeds, primarily fatty acids, “can serve as precursors to steroid hormones, potentially, or could impact inflammation,” Dr. Emily Jungheim, chief of reproductive endocrinology and infertility at Northwestern Medicine, told TODAY.

It’s “possible” that eating more fatty acids could affect hormone levels and “create a more favorable environment for hormone signaling,” she said. There are few studies suggesting that eating sesame seeds and flax seeds can affect hormone levels in women.

But there are no randomized controlled trials on seed cycling specifically, Jungheim said. And infertility is more likely to be caused by other underlying health issues that can’t be solved with seeds, she added.

Does seed cycling improve fertility?

“The general idea that nutrition can impact your fertility is absolutely valid,” said Linsenmeyer, who is also an assistant professor at Saint Louis University. And there is some evidence that certain dietary factors (like unsaturated fats, whole grains, fish and vegetables) as well as being underweight or having obesity can make a difference.

“But there is no evidence that this specific practice — seed cycling — can impact fertility in any clinically significant way,” she said. “In terms of actually making a clinically significant impact on hormonal levels, there’s just no science there to support that,” Linsenmeyer said.

The truth is, “if somebody’s struggling with infertility, usually there’s some major thing that needs to be addressed,” Jungheim said. It might be that someone isn’t ovulating, that there’s an underlying health condition (like thyroid disease) making it more challenging to get pregnant or that their partner’s sperm count is too low, for instance.

But, if issues like those are causing fertility problems, eating a bunch of seeds isn’t likely to help. “There’s nothing I can think of physiologically or scientifically that would make it biologically feasible that eating a specific type of seed in one portion of the cycle would make you ovulate,” Jungheim said.

There may be other benefits to eating seeds, of course

“Seeds are very nutritious,” Linsenmeyer said. “So, the bottom line is yes — if you want to incorporate more seeds in your diet, go for it.” They can be a great source of fiber, protein and omega-3 fatty acids, she said.

But if you’re adding a lot of seeds to your diet at once, you may experience some gastrointestinal changes as your body adjusts to having more fiber. “Frankly, I would expect to see changes in bowel movements that might be just, like, startling to people,” Linsenmeyer said. “The insoluble fiber content adds a lot of bulk to the stool.”

You might also notice yourself feeling fuller sooner or not feeling as hungry when it comes time for your next meal due to the high fat content in seeds, she said.

All of that is why Linsenmeyer recommends people who are interested in adding more seeds to their diet do so gradually over the course of a week or two — and be sure to drink plenty of water.

Before you try seed cycling to boost fertility…

First, remember that it can take a while to get pregnant — and that is generally normal. “If you’re younger than 35, we generally recommend trying for a year,” Jungheim said, noting that over-the-counter ovulation prediction kits make it easier to know when you’re most fertile. For those over 35, she recommends checking in after six months.

But if you’re not having periods for three months in a row, that’s a sign that you may not be ovulating normally, Jungheim said, and you should talk with your doctor. Or, if you know you have a history of fibroids, endometriosis, PCOS or other issues that can affect fertility, it makes sense to check in with your doctor earlier on in the process, she said.

“I would encourage folks to get at least a diagnostic workup before turning to seed cycling,” Jungheim said. While treatments are not always covered by insurance, those initial tests usually are, she added. Early testing can screen for underlying (generally treatable) issues, like thyroid disease, and your diagnosis may be delayed if you’re spending time with seed cycling instead of talking to your doctor.

And recognize that there may also be emotional costs to pinning your hopes on something like seed cycling, Linsenmeyer added. “To me, the risk is getting somebody’s hopes up when there is no science to support the practice.”

Source: What Is Seed Cycling? Experts Weigh In On Eating Seeds For Fertility, Hormone Balance

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The Secrets Of A Successful Social Media Strategy For Startups

The age of social media has disrupted conventional ways of advertising and transformed the way that businesses reach consumers. In recent years, social media itself has undergone radical changes. Mike Mandell is a leading lawyer on social media thanks to the popularity of his legal tips and entertaining posts. Here he shares his advice for startups and their founders.

Alison Coleman: Why is it so important for startups to develop a great social media strategy for their business?

Mike Mandell: In the past, companies had to spend years amassing a large following to have any hope of a substantial number of views. Today, short-form video content, 15 to 30 seconds in length, is the cutting edge. Quickly produced videos can launch a business into the spotlight overnight, or even faster.

By studying what captured the public’s attention, companies can follow up with more viral content on a consistent basis, keeping their brand relevant and vital. Social media represents a quantum leap in identifying niche markets. Algorithms know things about users that they might not know themselves. As the software learns more about individuals, its ability to influence them only grows.

Coleman: Many startup founders lack the time, resources, and budgets to create valuable viral content; how can they compete?

Mandell: First, let’s talk about budgets. With the dominance of short-form content, it’s not necessary to have one. Posting consistent, quality content alone can create a huge audience for your work. That said, even a shoestring budget can go far on social media. Allocating a few hundred bucks to boosting your posts would allow you to experiment until you see enough leads to justify the time and effort.

The beauty of this system is that cost scales with your success. If you’re making money, you’ll eventually want to hire staff to handle your social media. Businesses can do this more cheaply than they might expect. A million young people ache for these jobs, and they don’t expect a fortune in salary. They want in the game. That’s it. Keep in mind that these skills are learnable, as well. Consider offering paid internships.

Coleman: What tips do you have for startups for building a winning social media presence that pays dividends?

Mandell: Build an inventory before you launch. Have 10 to 20 videos on hand as a cushion. Avoid making your topics too time-sensitive, if you require your ‘rainy day’ fund for later, rather than sooner. Keep a list of your thoughts. You’d be surprised how often you can forget a brilliant idea if you don’t record it. Listen to followers and consumers; they’ll tell you what they want. On social media they leave comments. Read these and let the feedback, both positive and negative, guide your future content.

The algorithms favor consistency, and part of maintaining your audience is ensuring followers know when to expect something new. If you release new content on Monday and Friday, then do that consistently. Even consider letting subscribers know you’ll be going away on vacation for a week. If your content isn’t seeing sufficient returns, consider taking a hard look at its appeal from an audience-centered perspective.

Coleman: What’s the key to going viral?

Mandell: Firstly, you don’t need to go viral to have a successful social media presence. The key is engagement, not the number of views or your follower count. The more people engage with your content, the farther along you are in creating a community of supporters who love your brand.

Focus on that. I’d rather have 1,000 followers who engage with me all the time than 500,000 who never comment. People want to do business with someone they feel connected to, and social media provides you with that opportunity. A tight-knit audience that has ‘buy-in’ will do more for you than a huge passive following.

When it comes to creating viral content, the keys are to innovate, engage with followers, produce solid material, and release it on a consistent schedule. Most importantly, persist. One of the quickest ways to fail involves assuming you’ll strike gold, failing to do so, and quitting. Building a following on social media can be a grind. Luck does indeed play a role. But the longer you push, the luckier you are bound to get.Coleman: What are the common social media mistakes made by startups and small businesses, and how can they be corrected?

Mandell: Don’t develop a persona and try to perform. Be genuine. People respond to authenticity. And don’t bandwagon. If you just echo what everyone else is already saying, then you’ll get lost in the shuffle. Most people can tell you are just fishing for likes or followers. Instead, create a purposeful brand and stick to it, even when others shift in another direction. People can change their minds overnight, and they might switch back before you know it. Your consistency will beget their trust.

Be careful what you say. What you put online stays there. This goes for private messages, which someone could screenshot and share on multiple platforms. Finally, long-form content is popular – but only if you have a base audience that wants it. If not, short means short. If it’s not essential to post, remove it.

I’m a freelance journalist, founder of Coleman Media. For the last 20 years I’ve covered business stories for national and international online and

Source: The Secrets Of A Successful Social Media Strategy For Startups

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Beyond Psilocybin: These Mushrooms May Offer Brain-Boosting Compounds, Too

While the trippier fungi have stolen the show, several of their relatives are being investigated to treat common mental health conditions and neurodegenerative disorders.

Psilocybin, a psychoactive compound found in some psychedelic species of fungi, has received a flood of attention in recent years for its potential in treating mental health conditions like anxiety, depression and PTSD. But it isn’t just trippy fungi that could deliver major brain benefits:

Scientists are also looking into a host of other species that could help combat conditions affecting the mind, such as neurodegenerative disorders like Alzheimer’s and Parkinson’s disease and common mental illnesses.

Fungi have long attracted scientific inquiry. For starters, they’re known to offer diverse, powerful collections of compounds called secondary metabolites that help them compete in the wild. These compounds have already provided us with a range of life-saving drugs, such as the antibiotic penicillin, the chemotherapy treatment Taxol, and the cholesterol medication Lovastatin.

Many types of fungi are sold in the U.S. as supplements in the form of ground powders. Lab experiments, meanwhile, typically extract biologically-active compounds using ethanol, certain enzymes or other agents that seem to boost their positive effects.

And while recent epidemiological studies have identified a possible link between regularly eating mushrooms and a reduced risk of cognitive decline, researchers hope to incorporate the powerful fungi-derived compounds into more targeted treatments.

Currently, the vast majority of studies have analyzed the effects of fungi extracts and certain isolated compounds on cells and rodents, along with relatively tiny samples of humans, so it’s far too early to make any conclusions.

Still, some results have nevertheless been encouraging. Here are some varieties that are currently being studied for their potential brain benefits:

Shiitake

While it’s one of the most popular edible mushrooms worldwide, you may not know that Lentinula edodes has also received attention in labs for its possible neurological applications. Shiitake are particularly prized for carbohydrates called polysaccharides, specifically beta-glucans, that are also found in the cell walls of various fungi. Beta-glucans offer a variety of possible advantages, including their ability to reduce inflammation, regulate the immune system and combat infections. 

In recent years, scientists have found that beta-glucans can improve gut microbiome diversity in mice. This is a win for the brain, because the two are closely linked via a two-way communication channel called the gut-brain axis. In fact, feeding mice beta-glucans from Shiitake mushrooms helped counteract the cognitive impairments caused by a high-fat diet — which wreaks brain inflammation — a 2021 Journal of Translational Medicine study found.

Lion’s Mane

The hairy-looking Hericium erinaceus, commonly referred to as lion’s mane, is found in Asia, Europe and North America on decaying or dead trees. Research has indicated that it could help treat or prevent a wide range of conditions, including cancer, diabetes and high cholesterol. Among other medicinal mushrooms, this species has received particular attention for its potential neuroprotective properties. These may stem from chemical compounds that can promote cell growth, fight inflammation and regulate reward pathways within the brain. 

Studies in mice and cells have accordingly suggested that lion’s mane may improve mental function in people with Alzheimer’s and help treat epilepsy. Small human trials suggest it could mitigate depression, improve sleep quality and alleviate early-stage cognitive decline, but researchers have called for more rigorous studies in people.

Cordyceps

This parasitic genus of fungus is known to get gruesome. For example, the Ophiocordyceps unilateralis species can infiltrate the bodies of ants via spores and turn them into “zombies” before sprouting out of the insects’ heads. Fittingly, Cordyceps even inspired a zombie-themed horror video game series

Despite their frightening behavior toward insects, humans have long prized these Cheeto-like fungi. Chinese medicine has used the Ophiocordyceps sinensis species to promote lung and kidney health since at least the 18th century. Natural forms of O. sinensis, which grow high in the Tibetan Plateau and Himalayas on ghost moths, can cost up to $63,000 a pound. Research teams therefore commonly study samples of this species that have been cultivated in labs.

In recent years, various varieties of Cordyceps have been studied for their anti-inflammatory, antitumor, immune system-regulating and neuroprotective properties, among others. Their various powers are thought to come from a unique compound called cordycepin, along with polysaccharides and sterols, which are somewhat similar to the cholesterol produced by humans. 

Experiments with animal models have demonstrated that the compounds within Cordyceps could help mitigate learning and memory impairment, symptoms associated with neurological diseases like Alzheimer’s and Parkinson’s disease. This could occur through various mechanisms, including cordycepin’s ability to prevent neuronal cell death.

Chaga

The Inonotus obliquus fungus, commonly called chaga, typically grows as a parasite on birch trees in cold climates. It has long been incorporated in folk medicine in China, Korea, Japan and eastern Europe. And historical sources claim that 12th-century Kiev Prince Vladimir Monomakh used chaga to get rid of a lip tumor.

As with the other fungi on this list, the polysaccharides within I. obliquus may offer a range of helpful properties, including antitumor, anti-fatigue, antioxidant, antiviral and anti-inflammatory effects.

So far, compounds isolated from chaga have been shown to protect against Alzheimer’s and Parkinson’s diseases in cell studies by mitigating oxidative stress, which can cause excess unstable molecules called free radicals to attack brain cells. While some medicinal fungi have received human trials, albeit tiny ones, chaga does not appear to have been tested in humans for any possible neurological benefits. 

Reishi

Known as the “Mushroom of Immortality” in Korea and China, reishi, or Ganoderma lucidum, sprouts up on dying or dead trees, including maple, elm and oak. In Chinese medicine, reishi is used to boost overall health and longevity. Like plenty of other sought-after fungi, reishi may get its magic from substances such as sterols, polysaccharides and peptides.

Reishi offers a laundry list of potential benefits, such as sedative, anti-inflammatory, antiviral, and antitumor effects. Evidence suggests that it could prove a helpful treatment for neurodegenerative conditions. Studies performed on cells and animals have highlighted the possibility that the polysaccharides from Ganoderma lucidum could, for example, slow the progression of Alzheimer’s disease. These substances may encourage neuron growth in the brain and alleviate cognitive decline.

Results in humans, however, haven’t been as promising. A first-of-its-kind experiment in just 42 people with Alzheimer’s disease found that spore powder made from G. lucidum failed to improve symptoms or enhance patients’ quality of life measurements, according to a 2018 Medicine study. But the authors noted that it was a brief treatment period (six weeks) and small sample size.

If future research succeeds (and plenty more is needed), this mushroom could perhaps compete with widely prescribed antidepressants. Reishi extracts seemed to exhibit an effect comparable to that of the SSRI fluoxetine in studies from 2017 and 2021 performed on mice. Its relative Ganoderma applanatum might also help ease depression and anxiety, according to another mouse experiment.

Beyond that, a small study in 64 women with fibromyalgia failed to find statistically significant effects of Ganoderma lucidum supplementation on subjective measures like feelings of happiness, depression and life satisfaction. But researchers did notice a positive trend in these outcomes post-treatment, as reported in the journal Healthcare in 2020. And in a 2011 study assessing reishi’s effect on fatigue in breast cancer patients, subjects reported reduced anxiety and depression.

By Molly Glick

Source: Beyond Psilocybin: These Mushrooms May Offer Brain-Boosting Compounds, Too | Discover Magazine

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