Behavior Is a Miracle Drug

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Healthcare is broken. Chronic diseases are eating up an increasing share of healthcare resources in every healthcare system across the world in ways that are not sustainable. Yes, there is a golden age of innovation happening in the form of new technologies like gene therapy, neural technology, immunotherapy, and increasingly the impact of AI on diagnoses and drug development.

But we can’t let these extraordinary technological advances blind us to the tragedy of modern healthcare and to the much neglected miracle drug right in front of us: our daily behaviors. Whether for preventing disease or optimizing the treatment of disease, behavior is indeed a miracle drug. There are five foundational daily behaviors that, together, make up this miracle drug: sleep, food, movement, stress management, and connection.

Because the science is clear that when we improve these daily aspects of our lives, dramatic improvements in our health and well-being follow. The breakthroughs this can bring in our health aren’t over the horizon—they’re here right now…..Continue reading

By: Arianna Huffington

Source: Behavior Is a Miracle Drug | Time

Critics:

As experimental behavioural psychology is related to behavioral neuroscience, we can date the first researches in the area were done in the beginning of 19th century. Later, this essentially philosophical position gained strength from the success of Skinner’s early experimental work with rats and pigeons, summarized in his books The Behavior of Organisms and Schedules of Reinforcement.

Of particular importance was his concept of the operant response, of which the canonical example was the rat’s lever-press. In contrast with the idea of a physiological or reflex response, an operant is a class of structurally distinct but functionally equivalent responses. For example, while a rat might press a lever with its left paw or its right paw or its tail, all of these responses operate on the world in the same way and have a common consequence.

Operants are often thought of as species of responses, where the individuals differ but the class coheres in its function-shared consequences with operants and reproductive success with species. This is a clear distinction between Skinner’s theory and S–R theory. Skinner’s empirical work expanded on earlier research on trial-and-error learning by researchers such as Thorndike and Guthrie with both conceptual reformulations

Thorndike’s notion of a stimulus-response “association” or “connection” was abandoned; and methodological ones—the use of the “free operant”, so-called because the animal was now permitted to respond at its own rate rather than in a series of trials determined by the experimenter procedures. With this method, Skinner carried out substantial experimental work on the effects of different schedules and rates of reinforcement on the rates of operant responses made by rats and pigeons.

He achieved remarkable success in training animals to perform unexpected responses, to emit large numbers of responses, and to demonstrate many empirical regularities at the purely behavioral level. This lent some credibility to his conceptual analysis. It is largely his conceptual analysis that made his work much more rigorous than his peers, a point which can be seen clearly in his seminal work Are Theories of Learning Necessary? in which he criticizes what he viewed to be theoretical weaknesses then common in the study of psychology.

An important descendant of the experimental analysis of behavior is the Society for Quantitative Analysis of Behavior. As Skinner turned from experimental work to concentrate on the philosophical underpinnings of a science of behavior, his attention turned to human language with his 1957 book Verbal Behavior and other language-related publications; Verbal Behavior laid out a vocabulary and theory for functional analysis of verbal behavior, and was strongly criticized in a review by Noam Chomsky.

Skinner did not respond in detail but claimed that Chomsky failed to understand his ideas, and the disagreements between the two and the theories involved have been further discussed. Innateness theory, which has been heavily critiqued, is opposed to behaviorist theory which claims that language is a set of habits that can be acquired by means of conditioning. According to some, the behaviorist account is a process which would be too slow to explain a phenomenon as complicated as language learning.

What was important for a behaviorist’s analysis of human behavior was not language acquisition so much as the interaction between language and overt behavior. In an essay republished in his 1969 book Contingencies of Reinforcement, Skinner took the view that humans could construct linguistic stimuli that would then acquire control over their behavior in the same way that external stimuli could. The possibility of such “instructional control” over behavior meant that contingencies of reinforcement would not always produce the same effects on human behavior as they reliably do in other animals.

The focus of a radical behaviorist analysis of human behavior therefore shifted to an attempt to understand the interaction between instructional control and contingency control, and also to understand the behavioral processes that determine what instructions are constructed and what control they acquire over behavior. Recently, a new line of behavioral research on language was started under the name of relational frame theory.

Health behavior refers to a person’s beliefs and actions regarding their health and well-being. Health behaviors are direct factors in maintaining a healthy lifestyle. Health behaviors are influenced by the social, cultural, and physical environments in which we live. They are shaped by individual choices and external constraints. Positive behaviors help promote health and prevent disease, while the opposite is true for risk behaviors.

Health behaviors are early indicators of population health. Because of the time lag that often occurs between certain behaviors and the development of disease, these indicators may foreshadow the future burdens and benefits of health-risk and health-promoting behaviors. Health behaviors impact upon individuals’ quality of life, by delaying the onset of chronic disease and extending active lifespan.

Smoking, alcohol consumption, diet, gaps in primary care services and low screening uptake are all significant determinants of poor health, and changing such behaviors should lead to improved health. For example, in US, Healthy People 2000, United States Department of Health and Human Services, lists increased physical activity, changes in nutrition and reductions in tobacco, alcohol and drug use as important for health promotion and disease prevention.

Any interventions done are matched with the needs of each individual in an ethical and respected manner. Health belief model encourages increasing individuals’ perceived susceptibility to negative health outcomes and making individuals aware of the severity of such negative health behavior outcomes. E.g. through health promotion messages.

In addition, the health belief model suggests the need to focus on the benefits of health behaviors and the fact that barriers to action are easily overcome. The theory of planned behavior suggests using persuasive messages for tackling behavioral beliefs to increase the readiness to perform a behavior, called intentions. The theory of planned behavior advocates the need to tackle normative beliefs and control beliefs in any attempt to change behavior.

Challenging the normative beliefs is not enough but to follow through the intention with self-efficacy from individual’s mastery in problem solving and task completion is important to bring about a positive change. Self efficacy is often cemented through standard persuasive techniques.

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What Does a Sell-By Date Mean? What to Know About Food Expiration Dates

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Here’s one simple way to cut your grocery bill: Stop throwing away so much food. That may seem obvious, but you could actually be tossing perfectly good food without realizing it. If you’ve been following sell-by dates on labels in the name of food safety, you may be wasting a ton of food unnecessarily.

Each year, Americans waste $161 billion in food at the retail and consumer levels, a lot of it unnecessary, according to the U.S. Food and Drug Administration. How much are you wasting at home that you don’t have to?

What Do Sell-By Dates Really Mean?

A sell-by date tells stores how long wikipediato display a product for sale. It’s based on when a manufacturer believes food will be freshest. Sell-by dates are just one kind of label manufacturers might use on your food, and none of them mean food will be unsafe to eat after the date, the USDA explains.

No federal regulations require companies to include date labels on food (with the exception of baby formula). For those companies that do, nothing regulates when those dates should be or what they actually mean. Without a consistent system or actual safety guidelines, most of us don’t know what to make of any of it….Continue reading

By:

Source: How to Decode What a Sell-By Date Means on a Food Label

Critics:

Generally, foods that have a use by date written on the packaging should not be eaten after the specified date. This term is generally applied to foods that may go bad due to physical instability, chemical spoilage, bacterial spoilage, pathogenic spoilage, or other factors that can make the food injurious to health. Milk, meat, fish and eggs are all subject to spoilage. Such foods should be thrown away if past their use by date or if showing signs of deterioration such as changes in smell or color.

Fruits, vegetables, breads and other baked goods can also spoil, but may be less likely to become dangerous. It is important to follow storage and preparation instructions carefully for perishable foods. Some product may require refrigeration. Others may need to be cooked to particular temperatures. Most U.S. expiration dates are used as guidelines based on normal and expected handling and exposure to temperature.

Use prior to the expiration date does not guarantee the safety of a food or drug, and a product is not necessarily dangerous or ineffective after the expiration date. According to the United States Department of Agriculture, “canned foods are safe indefinitely as long as they are not exposed to freezing temperatures, or temperatures above 90 °F (32.2 °C). If the cans look okay, they are safe to use. Discard cans that are dented, rusted, or swollen.

High-acid canned foods (tomatoes, fruits) will keep their best quality for 12 to 18 months; low-acid canned foods (meats, vegetables) for 2 to 5 years”. 80 °F (27 °C). Expiration dates for infant formula should not be ignored. If formula is stored too long, it may lose its nutritional value. The expiration date of pharmaceuticals specifies the date the manufacturer guarantees the full potency and safety of a drug. Most medications continue to be effective and safe for a time after the expiration date.

A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. A study conducted by the U.S. Food and Drug Administration covered over 100 drugs, prescription and over-the-counter. The study showed that about 90% of them were safe and effective as long as 15 years past their expiration dates. Joel Davis, a former FDA expiration-date compliance chief, said that with a handful of exceptions – notably nitroglycerin, insulin and some liquid antibiotics – most expired drugs are probably effective.

Best before or best by dates appear on a wide range of frozen, dried, tinned and other foods. These dates are advisory and refer to the quality of the product, in contrast with use by dates, which may indicate that the product may no longer be safe to consume after the specified date. Food kept after the best before date will not necessarily be harmful, but may begin to lose its optimum flavour and texture.

Eggs can be a special case, since they may contain salmonella which multiplies over time; they should therefore be eaten before the best before date. In Britain, this is 21 days from when they were laid. In the USA, this is a maximum of 45 days after the eggs are packed. Quality of the eggs will degrade over time, due to a variety of factors. As a result, some prefer to use fresher eggs for eating and eggs a few days old for cooking.

Sometimes the packaging process involves using pre-printed labels, making it impractical to write the best before date in a clearly visible location. In this case, wording like best before see bottom or best before see lid might be printed on the label and the date marked in a different location as indicated.

Sell by date is a less ambiguous term for what is often referred to as an “expiration date”. Most food is still edible after the expiration date. A product that has passed its shelf life might still be safe, but quality is no longer guaranteed. In most food stores, waste is minimized by using stock rotation, which involves moving products with the earliest sell by date from the warehouse to the sales area, and then to the front of the shelf, so that most shoppers will pick them up first and thus they are likely to be sold before the end of their shelf life.

This is important, as consumers enjoy fresher goods, and furthermore some stores can be fined for selling out of date products; most if not all would have to mark such products down as wasted, resulting in a financial loss. Sale of expired food products, per se, is lightly regulated in the US. Some states restrict or forbid the sale of expired products, require expiration dates on all perishable products, or both, while other states do not.

However, sale of contaminated food is generally illegal, and may result in product liability litigation if consumption of the food results in injury. The Food and Drug Administration in the United States notes that “[a] principle of U.S. food law is that foods in U.S. commerce must be wholesome and fit for consumption”. However, with the exception of infant formula, the United States government does not require or specify uniform terminology for use on food labels, the use of date labeling is entirely at the discretion of the manufacturer, and dates on labels do not indicate product safety.

U.S. law does state that labels should be truthful and not misleading. Specific foods may be subject to regulations from the Food Safety and Inspection Service. With the exception of infant formula, the laws that the Food and Drug Administration (FDA) administers do not preclude the sale of food that is past the expiration date indicated on the label. FDA does not require food firms to place terms such as expired by, use by and best before dates on food products. This information is entirely at the discretion of the manufacturer.

After losing a lawsuit, pharmacy chain CVS implemented a system that causes its registers to recognize expired products and avert their sale. The United States Department of Agriculture (USDA), which regulates fresh poultry and meats, only requires labeling of the date when poultry is packed. However, many manufacturers also voluntarily add sell-by or use-by dates.

A freshness date is the date used in the American brewing industry to indicate either the date the beer was bottled or the date before which the beer should be consumed. Beer is perishable. It can be affected by light, air, or the action of bacteria. Although beer is not legally mandated in the United States to have a shelf life, freshness dates serve much the same purpose and are used as a marketing tool.

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Findings About Dostarlimab, A New Antibody Drug, Very Encouraging, Says Expert In Cancer Treatment

Representational image. Image Credit: Kidney Research UK

According to New York Times, in a small clinical trial, 18 patients took a drug called Dostarlimab for around six months, and in the end, every one of them saw their tumours disappear. The findings concerning dostarlimab, an antibody drug, in experimental treatment of rectal cancer patients is very encouraging but there is need for long-term studies to understand the real impact, an expert in cancer treatment has said.

“This new trial at MSKCC in a small number of patients, with locally advanced rectal cancer patients who had MMR (MisMatch repair) deficiency, have shown total disappearance of tumour without any additional treatment in all 100 percent of them. This is very encouraging but we must note that long term studies are required to understand the real impact,” Dr. (Col.) R. Ranga Rao, Chairman, Oncology, of Paras Hospitals in Gurugram said.

“The drug is still investigational and the trial is limited to patients of a specific type , that constitute about 4 to 5 per cent of rectal cancers. While this is highly encouraging, we must not prematurely jump to conclusions that we have found a cure for all cancers, all stages, and no chemotherapy, surgery is ever required,” he added.

He said it is well recognized that Immunotherapy with PDL 1 blockers in MMRd patients is effective. “Already immunotherapy has made a big difference in the field of cancer of all types. Several earlier trials have shown encouraging responses,” Dr Rao said.

In what appears to be a miracle and ‘first time in history’, a small clinical trial has found that every single rectal cancer patient who received an experimental treatment found that their cancer had vanished.

According to New York Times, in the small clinical trial conducted by Memorial Sloan Kettering Cancer Center, 18 patients took a drug called Dostarlimab for around six months, and in the end, every one of them saw their tumours disappear. Dr Luis A. Diaz J. of New York’s Memorial Sloan Kettering Cancer Center (MSKCC) said this was “the first time this has happened in the history of cancer”.

According to experts, Dostarlimab is a drug with laboratory-produced molecules and it acts as substitute antibodies in the human body. The cancer is undetectable by physical exam; endoscopy; positron emission tomography or PET scans or MRI scans, added Experts. This proves that Dostarlimab can be a ‘potential’ cure for one of the most deadly common cancers.

According to New York Times, patients involved in the clinical trial earlier underwent treatments such as chemotherapy, radiation, and invasive surgery that could result in bowel, urinary, and even sexual dysfunction. The 18 patients went into the trial expecting to have to go through these procedures as the next step. However, to their surprise, no further treatment was needed.

The findings of this trial have shocked experts and they have pointed out that complete remission in every single patient is “unheard-of”. Dr Alan P. Venook, who is a colorectal cancer specialist at the University of California, said that the complete remission in every single patient is “unheard-of”. He hailed the research as a “world-first”. Experts stated that the research was impressive as not all of the patients suffered significant complications from the drug trial.

Critics:

Tesaro, a biotech company based out of Massachusetts developed the drug. Tesaro was acquired by GlaxoSmithKline in 2019, dostarlimab is also known by the brand name Jemparli. Dostarlimab was developed to treat women with recurrent or advanced endometrial cancer.

On August 17, 2021, the FDA approved dostarlimab-gxly (brand name Jemperli) for adult patients with mismatch repair-deficient recurrent or advanced solid tumours, as determined by an FDA-approved test, that have progressed on or following prior treatment and who have no satisfactory alternative treatment options.

Rectal cancer remission

According to reports, 18 patients in the clinical trial took Dostarlimab for around six months and after over 12 months the doctors found that their cancer disappeared. While it’s a small trial so far, the results have been impressive; they were published in The New England Journal of Medicine and featured at the nation’s largest gathering of clinical oncologists in June 2022.

In every case, rectal cancer disappeared after immunotherapy — without the need for the standard treatments of radiation, surgery, or chemotherapy — and cancer has not returned in any of the patients, who have been cancer-free for up to two years.

It’s incredibly rewarding to get these happy tears and happy emails from the patients in this study who finish treatment and realise, ‘Oh my God, I get to keep all my normal body functions that I feared I might lose to radiation or surgery,’ expressed Dr Andrea Cercek, Medical Oncologist, Memorial Sloan Kettering Cancer Center (MSK).

Dr Cercek added, “The most exciting part of this is that every single one of our patients has only needed immunotherapy. We haven’t radiated anybody, and we haven’t put anybody through surgery.” She continued, “They have preserved normal bowel function, bladder function, sexual function, fertility. Women have their uterus and ovaries. It’s remarkable.”

This clinical trial could pave the way for treating other forms of cancer in the future. As the trial continues at MSK, Dr Luis Alberto Diaz, Medical Oncologist, Memorial Sloan Kettering Cancer Center (MSK) said, “It’s the tip of the iceberg.” He explains, “We are investigating if this same method may help other cancers where the treatments are often life-altering and tumours can be MMRd. We are currently enrolling patients with gastric (stomach), prostate, and pancreatic cancers.”

Dostarlimab clinical trial reception by the Indian medical community

Since the trial results have been published, it has created a lot of buzz and has got the entire medical community discussing how it could pave the path for future treatment for various cancers, ETHealthWorld spoke to few experts on the drug trial. Commenting on the trial, “It is definitely a big step towards efficient cancer care. The preliminary data on Dostarlimab PD1 monotherapy has been very encouraging in high-risk rectal cancer patients and has been recently presented at the ASCO meeting in Chicago and subsequently published in NEJM.

We would definitely need further studies on larger groups of patients across the globe to establish it as a standard of care for rectal cancer. Trials are also being conducted to study its effectiveness for cervical cancer, and endometrial cancer amongst others,” said Dr Pankaj Kumar Panda, Senior Research Officer, Apollo Proton Cancer Centre.

Source: Findings about Dostarlimab, a new antibody drug, very encouraging, says expert in cancer treatment

More contents:

New therapies reduce breast cancer treatment time by 70-90 per cent, say experts The New Indian Express

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00:42 Thu, 27 Octpigenetic field defects in progression to cancer” Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression”.pigenetic modifications in cancer”.

Epigenetics Offer New Horizons for Colorectal Cancer Prevention”. Epigenetics and colorectal cancer”.DNA Methylation in Cancer and Aging”Mutator pathways unleashed by epigenetic silencing in human cancer”. “Epigenetic field defects in progression to cancer”

“Colorectal Cancer”Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer”.The consensus molecular subtypes of colorectal cancer”.“Colorectal Cancer”Colon, Rectosigmoid, and Rectum Equivalent Terms and Definitions C180-C189, C199, C209,

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Impact Of Covid-19 Pandemic Extends To Tuberculosis And Neglected Tropical Diseases

Last month, the World Health Organization reported that for the first time in 15 years the number of people who have died from tuberculosis has increased. Worldwide, in 2020, more than 1.5 million deaths were attributed to tuberculosis; the first year-on-year increase since 2005. Multiple reasons have been cited, one of which is diversion of resources due to the Covid-19 pandemic.

And, tuberculosis is not the only diseasethat has been impacted, with disproportionately severe health burdens on the world’s poorest populations.

Since the spring of 2020, there has been acute disruption of activities, such as neglected tropical disease (NTD) control and elimination programs. Across the globe, for example, mass drug administration campaigns targeting NTDs have been postponed. NTDs are a heterogeneous group of infections which are common in developing regions of Africa, Asia, and the Americas.

These diseases – caused by a variety of pathogens, including viruses, bacteria, protozoa, and parasites – include, among others, onchocerciasis (river blindness), African trypanosomiasis, leishmaniasis, cholera, Chagas disease, and Dengue fever. Diseases are said to be neglected if they are (often) overlooked and therefore underfunded by drug developers, owing to a lack of commercial prospects.

And, while tuberculosis has also suffered from neglect, it belongs to the so-called “big three infectious diseases” – HIV/AIDS, tuberculosis,and malaria – which have generally received more media attention and research and development funding than the NTDs.

The WHO had developed an NTD roadmap that was meant to officially launch in June 2020. The roadmap included specific disease targets to control and eliminate NTDs by 2030. Not only did the Covid-19 pandemic postpone the launch of the work plan, many NTD activities that had been ongoing were suspended to prevent the risk of additional transmission of the coronavirus.

In fact, interruptions in NTD program work were experienced in at least 44% of low and middle income countries: Specifically, suspension of mass administration campaigns of vaccines and treatments, case detection, and vector control. In addition, there was disruption to supply chains and reduction in the manufacturing of active pharmaceutical ingredients. In brief, there was diversion of financial resources, which effectively meant a reassignment of NTD personnel to the Covid-19 response.

It’s not all been bad news, as a month ago the WHO endorsed the first malaria vaccine (a recombinant, protein-based agent) for use among children in at-risk areas. Malaria is a preventable disease that kills around 500,000 people a year; mostly African children.

It should be noted, however, that most of the clinical development of the malaria vaccine occurred prior to the Covid-19 pandemic. Furthermore, the vaccine – called Mosquirix – has modest efficacy, as it reduces the number of severe malaria cases by approximately 30%.

To save the most lives, African countries must continue to scale up teams of local health workers to identify and respond to cases, and increase access to mosquito nets and antimalarial drugs, such as the fixed dose combination Coartem (artemether/lumefantrine). Yet, it’s precisely in these areas that the pandemic has been the most disruptive.

Opportunity Cost

One of the core tenets of economics is that resource allocation decisions invariably involve trade-offs. As an illustration, there is an opportunity cost of allocating large amounts of resources towards the Covid-19 response. The dollars spent on combating the coronavirus can’t be used to address other diseases.

Unless the overall amount of healthcare resources is expanded, there will be forgone alternatives left unfunded. And, government budgetary constraints often prevent expansion of healthcare budgets from happening. Alternatively, it is difficult to draw down budgets in other sectors, such as defense, in order to fund healthcare sector expansion, whether domestically or for the purposes of international health aid projects.

Budget impact analyses lay bare the individuals or groups who lose out; in other words, those who bear the opportunity cost of spending resources in one area, say, Covid-19, rather than another.

This doesn’t mean that a substantial amount of resources shouldn’t have been spent (or continue to be expended) on developing and paying for coronavirus vaccines or Covid-19 treatments. It does, however, imply that policymakers be made aware of forgone alternative uses of resources, account for the extent to which society can afford to crowd out non-Covid-19 resources, and fill in the budgetary gaps where necessary.

At multiple levels – local, state, federal, and global – when a healthcare system or international program with a relatively fixed budget “overpays” in one area, it must extract resources from elsewhere in the budget, or enlarge the budget.

Early in the pandemic, it was clear that federal regulators in the U.S. were aware of the issue of opportunity cost. In reallocating resources to address the novel coronavirus, the Food and Drug Administration (FDA) stated that new drug and biologics programs were being impacted by “considerable increases in Covid-19 related work.” As a result, the agency said “it’s possible that we will not be able to sustain our current performance level in meeting goal dates.”

Of course, this wasn’t just an issue at the FDA. Other government regulators, as well as global agencies such as WHO, were faced with similar sets of problems.

With government deficits running at record levels, it’ll be extraordinarily difficult to expand budgets to sustain non-Covid-19 related work at the desired levels. But, moving forward, such expansion will have to occur in order to meet the needs of underserved populations worldwide.

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I’m an independent healthcare analyst with over 22 years of experience analyzing healthcare and pharmaceuticals. Specifically, I analyze the value (costs and benefits) of biologics and pharmaceuticals, patient access to prescription drugs, the regulatory framework for drug development and reimbursement, and ethics with respect to the distribution of healthcare resources. I have over 110 publications in peer-reviewed and trade journals, in addition to newspapers and periodicals. I have also presented my work at numerous trade, industry, and academic conferences. From 1999 to 2017 I was a research associate professor at the Tufts Center for the Study of Drug Development. Prior to my Tufts appointment, I was a post-doctoral fellow at the University of Pennsylvania, and I completed my PhD in economics at the University of Amsterdam. Before pursuing my PhD I was a management consultant at Accenture in The Hague, Netherlands. Currently, I work on freelance basis on a variety of research, teaching, and writing projects.

Source: Impact Of Covid-19 Pandemic Extends To Tuberculosis And Neglected Tropical Diseases

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Related Contents:

Njie GJ, Morris SB, Woodruff RY, Moro RN, Vernon AA, Borisov AS (August 2018). “Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis”. American Journal of Preventive Medicine. 55 (2): 244–252. doi:10.1016/j.amepre.2018.04.030. PMC 6097523. PMID 29910114.

To Get Kids Vaccinated Against COVID-19, Health Officials Will Need to Reach Hesitant Parents

For as long as COVID-19 vaccines have existed, Melissa Chernofsky has been practically counting down the days until she can get one for her 5-year-old son. “If it was like getting Lollapalooza tickets, where you have to camp out all night, that’s what I would do,” says the 46-year-old from Brooklyn.

Chernofsky got a shot for herself as soon as she was eligible, and says she has never hesitated about doing the same for her child once she has the option. “As a parent, our number one job is to keep our kids safe,” she says. “I don’t really understand the idea that if there is a tool that can keep your kid from getting a disease, that you wouldn’t give it to them.”

One such tool—Pfizer-BioNTech’s COVID-19 vaccine for 5- to 11-year-olds—was authorized by the U.S. Food and Drug Administration on Oct. 29, bringing it a step closer to widespread availability. If the U.S. Centers for Disease Control and Prevention (CDC) recommends it for some or all children in that age group, kids could start getting vaccinated in the coming days.

But for every parent who feels as passionately pro-vaccine as Chernofsky does, there is at least one other with serious concerns about vaccinating their child. According to an October Kaiser Family Foundation poll, 27% of parents with kids ages 5 to 11 said they would vaccinate their child right away. But even more—35%—said they either definitely wouldn’t vaccinate or wouldn’t unless required. The rest were somewhere in the middle and said they would “wait and see.”

That split illustrates the significant challenge ahead of federal officials and health care workers, who must be ready to fulfill many families’ urgent desire for shots while also reaching those who are hesitant. Dr. Sara Bode, who is the medical director of school-based and mobile-care clinics for Ohio’s Nationwide Children’s Hospital, says pediatric hospitals and public-health departments around the country are gearing up to hold larger-scale clinics that can satisfy much of the pent-up demand for pediatric shots.

Vaccine supply is no longer an issue, so she thinks parents who want to vaccinate their kids should be able to do so easily. But “once this initial surge is over and everyone who wanted it gets it,” Bode says, “that’s where the real work starts to happen.”

Once it begins, a successful vaccine rollout must serve parents with questions or concerns about the vaccine in addition to those who are highly motivated—not just for the sake of those families, but for U.S. public health. Immunizing the roughly 28 million U.S. kids between the ages of 5 and 11 is a key piece of federal officials’ plan for controlling the virus, following their push to vaccinate older children after a shot was authorized for 12- to 15-year-olds in May.

“Not getting vaccinated means that our kids could potentially pass on the virus to others if they get infected,” U.S. Surgeon General Dr. Vivek Murthy said during a May call with parents, pediatricians, youth organizations and community leaders. “Breaking the chain of transmission is going to require us vaccinating our children.”

And, since 5- to 11-year-olds are too young to consent to vaccination themselves, that’s going to require convincing parents who, in many cases, are even more skeptical about vaccinating their children than they were about getting inoculated themselves. All told, about 78% of U.S. residents 12 and older have gotten at least one dose, but looking specifically at 12- to 15-year-olds, that number falls to about 57%.

“Messaging has to be to the parents, not to the kids,” Bode says. “It has to be sensitive and it has to be, usually, one-on-one,” so it can address each parent’s specific concerns. Individuals also tend to respond better when they hear about the vaccine from people who live and work in their community, rather than from government agencies or mass-communications campaigns, Bode adds.

The Biden Administration is banking on that. Its plan to vaccinate kids ages 5 to 11 hinges largely on distributing shots in pediatricians’ offices and schools, capitalizing on the trust parents often inherently hold for those institutions. “You are so often the people that folks want to hear from,” Murthy said on the May call with pediatricians and community leaders. “Your story, your outreach, can make all the difference in helping people get the information they need … and ultimately take that step of protecting their children.”

Dr. Tyree Winters, a New Jersey-based pediatrician, says he and his colleagues have been fielding questions from parents of older children for months, and he expects that to continue once younger kids can get the shot. Parents—even those who are vaccinated—often come in with concerns about their children experiencing vaccine-related side effects, or worried about misinformation they’ve read online.

(The incorrect idea that the shots can cause infertility is a big source of hesitation, he says.) Some are just plain uncomfortable with giving their kids a fairly new vaccine, even if they were willing to get it themselves. Getting through to these parents requires a balance of empathy and careful explanation of the science behind the vaccines, Winters says. “I let them know, ‘You’re not crazy, you’re not being over-dramatic, you’re not being unreasonable,’” he says. “That’s the beauty of being a pediatrician …we can relate to our patients and our families.”

Dr. Kelly Moore, CEO of the pro-vaccine Immunization Action Coalition, agrees that pediatricians can get through to many parents. But “not all children have a regular health care provider that they see, and public education through school systems will be important to reach families more widely,” Moore adds. Offering the shots in schools will also improve access to them, particularly for families that do not have a strong relationship with the traditional health system or parents who can’t take time off work to bring their child to a vaccine clinic.

The desire to keep kids in school can also convince some parents to vaccinate, says Dr. Sherri Young, who led adult and adolescent vaccination efforts in West Virginia’s Kanawha County. By mid-September, just a few weeks into the 2021-2022 school year, more than 1,800 U.S. schools had already experienced COVID-related closures, according to CDC data. That’s something both parents and kids want to avoid—and pitching vaccines as the way to do that can be effective, Young says.

“Sports are very important to kids. Going to school is very important to kids. Going to school is very important for parents,” Young says. “We’re going to keep our schools open longer if we all get in this together.”

Still, there are some parents who don’t believe their children need to be vaccinated, given the low rates of serious illness and death among people 18 and under. Others, concerned by reports of rare heart-related side effects among young people, think the risks of vaccination outweigh the benefits.

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In authorizing Pfizer’s shot, the FDA said the opposite is true. The vaccine appears more than 90% effective at preventing symptomatic infections among 5- to 11-year-olds, and no serious side effects have been reported among a group of more than 3,000 kids who participated in trials. The CDC’s advisory group will soon discuss in more detail whether certain groups of kids should or should not get the shot.

Moore says the recent Delta-related spike in cases should show parents that there is serious benefit to vaccination. It remains true that children develop severe disease much less often than adults and die from coronavirus even less frequently—but images of overflowing pediatric ICUs and kids on ventilators from this past summer prove that the worst does sometimes happen, she says. Vaccines drastically reduce that risk.

Getting parents to understand that could not only save their children’s lives, but also help the U.S. finally put the worst of the pandemic in the past.

By Jamie Ducharme

Source: How Health Officials Can Reach Vaccine-Hesitant Parents | Time

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