Weight Loss Drug Belviq Pulled From Market Over Cancer Risk

The maker of a weight loss drug pulled it from the market Thursday at the request of federal regulators, who said it posed a slight increased risk of cancer.

Japan’s Eisai Inc. said it was voluntarily withdrawing the drug, Belviq. (The company’s U.S. headquarters is in Woodcliff Lake, New Jersey.) However, the company said in a statement that it disagreed with the U.S. Food and Drug Administration’s interpretation of new data on the drug’s safety and still believes Belviq’s benefit outweighs the risk.

The FDA said patients should stop taking Belviq immediately, dispose of leftover pills and contact their doctor for advice on alternatives. The agency also told doctors to notify their patients to stop taking the drug.

Belviq was approved in 2012, roughly the same time that a couple of other promising weight loss drugs hit the market. None became the blockbusters they were expected to be, but they offered an option for the many people struggling with excess weight or obesity and related health problems.

Belviq was the first drug proven to help people lose weight and keep it off for several years without raising their risk for heart problems. That was the conclusion of a five-year, 12,000-patient study of the drug’s heart safety, which the FDA required Eisai to conduct as a condition of approval.

A recently completed FDA analysis of the data from that study showed 7.7% of participants who took Belviq were diagnosed with cancer, slightly more than the 7.1% who developed cancer in a comparison group given dummy pills. There was a range of cancers, with pancreatic, colorectal and lung cancer reported more often in the patients who took Belviq, the FDA said.

The agency said no special cancer screening is needed for anyone who took Belviq. It noted the increased risk was only seen after extended use of the drug.

Eisai said its assessment is that Belviq has more benefit than risk for its intended patients. It’s specifically approved for adults with a body mass index (BMI) of 30 and adults with a BMI of 27 who have other conditions that carry heart risks, such as high blood pressure, high cholesterol or Type 2 diabetes.

An extended-release version called Belviq XR also is being pulled from the market.

In testing before Belviq was approved, nearly half of participants given Belviq lost at least 5% of their weight over a year, and nearly one-quarter lost at least 10%. Those results were more than two times better than those of participants given dummy pills.

Of the competing drugs launched about the same time, Qsymia produced more weight loss than Belviq. Contrave, approved in 2014, produced similar weight loss to Belviq but carried a strong warning about the risk of increased suicidal thoughts and behavior.

The drugs’ costs hurt sales. Belviq and Contrave retail for roughly $300 per month without insurance, and Qysmia sells for about $200 per month, depending on the pharmacy.

Several older diet drugs were previously withdrawn from sale after they were found to raise the risk for heart valve damage, suicidal thoughts or other problems.

By Linda A. Johnson / AP February 14, 2020

Source: Weight Loss Drug Belviq Pulled From Market Over Cancer Risk

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Life-Changing Hacks For Coffee And Weight Loss

You may not be thinking of all of the goodness in your coffee when you wake up, stumble to the kitchen, and put on that pot. But, in addition to providing warmth, comfort, and a boost of fuel you need to start your day, that cup of Joe has amazing health benefits.

Your morning cup of coffee is filled with good-for-you antioxidants that can protect cells and combat free radicals in your body that cause illnesses and disease. Caffeine (in moderation) is also effective at boosting your metabolism for fat-burning benefits.

And, if you want to increase those benefits even more, this is the one calorie-burning nutrient nutritionists say you should start adding to your coffee for a flat stomach.

woman holding latte with latte artThanks to the popularity of diets like the Keto Diet, many people are getting on board with the fact that fat isn’t so bad for us after all.

The latest coffee craze is one that may have its roots in Keto logic, but has expanded to become mainstream popular thanks to three factors: it’s unusual, tasty, and, according to many who have tried it, works wonders when it comes to giving you energy and helping you burn stubborn fat.

woman leaning on counter drinking coffee out of mug

Drinking Bulletproof Coffee For Weight Loss

Add Butter To Your Coffee

To those already in the know, “bulletproof” coffee is coffee that has been spiked with butter. A few tablespoons of grass-fed butter can give your coffee a rich, buttery flavor that many say tastes like creamer. But its unusual and unexpected health benefits are what keep coffee lovers coming back for more.

espresso machine making a latteWhile there’s no denying that adding butter to your coffee also means adding upwards of 200 calories to a beverage that contains zero calories, some nutritionists say the benefits may outweigh the negatives.

“This may make the drink slower to digest and absorb, therefore potentially prolonging the effects of the caffeine,” Jaclyn London, MD, RD, CDN, Good Housekeeping Institute told Good Housekeeping. “As for the grass-fed distinction, proponents tout the slightly higher concentration of omega-3 fatty acids and some vitamins that come from cows grazing on an all-green diet.”

woman holding blue coffee mug

Correlation Between Bulletproof Coffee And Weight Loss

There is still a lack of data on whether bulletproof coffee truly helps your health, London says, and the only evidence that currently exists stems from research performed on rats. If it’s any consolation, those rats did experience higher metabolism and energy burn levels after drinking coffee with butter.

woman eating breakfast of yogurt cereal and strawberries in bedAccording to London, bulletproof coffee may help you lose weight — but that depends entirely on your overall diet.

“Bulletproof coffee could help you lose weight if you use it to replace a daily sugary short stack, or if you currently don’t eat breakfast at all,” London told Good Housekeeping. “In that case, BPC may provide a sense of fullness that you might not have experienced otherwise. Eating more calories from longer-lasting sources of energy can help you cut back on random grazing later on.”

But be aware because bulletproof coffee could also backfire on you: drinking your calories and sources of fat could make you feel more “ravenous,” London says. You could end up consuming even more calories each day.

cinnamon sticks and grown cinnamon on a table

If you aren’t sold on the idea of putting butter in your coffee, don’t worry. There are plenty of other healthy coffee additive alternatives that won’t pack on added calories and fat. Alternate coffee add-ons to consider include cardamom, cinnamon, vanilla extract, and coconut milk.

Source: Life-Changing Hacks For Coffee And Weight Loss

Entrepreneur Dave Asprey first added butter to his coffee to boost his brainpower. Now, he reveals what he learned about his brain to achieve his weight-loss goals. Subscribe to Dr. Oz’s official YouTube channel: https://bit.ly/1QhiDuv

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Exercise Can’t Save Us: Our Sugar Intake Is The Real Culprit, Say Experts

LEIPZIG, GERMANY - MAY 23: A man with a large belly eats junk food on May 23, 2013 in Leipzig, Germany. Photo by Sean Gallup/Getty Images

In a fascinating and scorching editorial in the British Journal of Sports Medicine, three authors argue that the myth that exercise is the key to weight loss – and to health – is erroneous and pervasive, and that it must end. The evidence that diet matters more than exercise is now overwhelming, they write, and has got to be heeded: We can exercise to the moon and back but still be fat for all the sugar and carbs we consume. And perhaps even more jarring is that we can be a normal weight and exercise, and still be unhealthy if we’re eating poorly. So, they say, we need a basic reboot of our understanding of health, which has to involve the food industry’s powerful PR “machinery,” since that was part of the problem to begin with.

The major point the team makes – which they say the public doesn’t really understand – is that exercise in and of itself doesn’t really lead to weight loss. It may lead to a number of excellent health effects, but weight loss – if you’re not also restricting calories – isn’t one of them. “Regular physical activity reduces the risk of developing cardiovascular disease, type 2 diabetes, dementia and some cancers by at least 30%,” they write. “However, physical activity does not promote weight loss.”

Plus, in the last 30 years, exercise has stayed about the same, while overweight and obesity have skyrocketed. So something else must be at play – like the type of food we’re eating. That part has gotten steadily worse over the years, as highly-processed sugary foods and sodas have taken over as our go-to choices. “According to the Lancet global burden of disease reports,” they write, “poor diet now generates more disease than physical inactivity, alcohol and smoking combined.” This is a disturbing statistic. But it gets worse.

The related and larger issue is that even normal weight people who exercise will, if they eat poorly, have metabolic markers that put them at very high risk of chronic illness and early mortality. “Up to 40% of those with a normal body mass index will harbour metabolic abnormalities typically associated with obesity, which include hypertension, dyslipidaemia, non-alcoholic fatty liver disease and cardiovascular disease.”

And the crux of the issue is this: We’re continually “fed” the idea that all that’s behind the rise in obesity is lack of exercise, or sedentariness. There have certainly been a lot of studies and popular articles suggesting that sitting is our downfall. Instead of effective messages about diet and health that science actually knows to be true, “members of the public are drowned by an unhelpful message about maintaining a ‘healthy weight’ through calorie counting,” the team writes, “and many still wrongly believe that obesity is entirely due to lack of exercise. This false perception is rooted in the Food Industry’s Public Relations machinery, which uses tactics chillingly similar to those of big tobacco.”

What we know to be true is much simpler: “Sugar calories promote fat storage and hunger,” the write. “Fat calories induce fullness or satiation.” For every additional 150 calories in sugar (i.e., a can of soda) a person consumes per day, the risk for diabetes rises 11-fold, regardless of how much or little we exercise. The single most effective thing people can do for their weight, they write, is to restrict calories – and even more, restrict carbohydrates.

So if this is all true, and research seems to suggest it is, how will it change? It might take quite a lot of work to shift our psychology around food, especially since advertising is so saturated with the message that carbohydrates are good for us. The celebrity endorsements might need to be tweaked, the authors say, and certainly the way foods are advertised and, perhaps, created, need to be shifted. The public should be repeatedly hit with the message that whole, natural foods, where possible and affordable is the best way to go. If you’re trying to lose weight, reduce your calories (especially sugars) – don’t think exercise alone will cut it. And even if you’re normal weight, you can’t subside solely on junk and stay healthy.

The authors end with this powerful finale: “It is time to wind back the harms caused by the junk food industry’s Public Relations machinery. Let us bust the myth of physical inactivity and obesity. You cannot outrun a bad diet.”

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Source: Exercise Can’t Save Us: Our Sugar Intake Is The Real Culprit, Say Experts

Fat Burning Soup Recipes For Weight Loss

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You’ll be able to see exactly how our professional chef does as he prepares a range of tasty dishes. So – even if you struggle to boil an egg, right now – you’ll soon be your very own master chef.. You can easily see how this program can provide the excitement of seeing you’ve lost ANOTHER few pounds nearly every time you step on the scales plus enjoy admiration of the opposite sex and the envy of your buddies. But you’re concerned that such an extensive program requires a large investment. So effective is my program just seven days should be enough time for you to start to notice the dramatic transformation in your body – because you could lose as much as TEN pounds in those seven days. So check out the program and try a few of the simple, mouthwatering recipes. Then be delighted as you discover just how easy – and tasty – it is to lose weight this revolutionary way eating just one scientifically designed meal a day…Read more

 

10 At-Home Exercises to Get Rid of Belly Fat In a Month – BRIGHT SIDE

How to get rid of belly fat quickly? 💪 If you have no time to go to the gym, try these 10 at-home exercises to finally lose belly fat once and for all! It will take you a month to reduce excess fat around your waistline. No leaving your house, no special equipment needed, and no excuses!

💥 TIMESTAMPS: #1. 5 Jumping Jacks + 1 Burpee 1:00 #2. 4 Mountain Climbers + 2 Sit-throughs 2:08 #3. Plyo step-ups 3:21 #4. Push-ups 4:08 #5. 2 Split Squat Jumps + 1 Burpee 4:50 #6. Toe Taps 5:34 #7. Plank Walks 6:29 #8. Sprinter Sit-ups 7:28 #9. Squat thrusts 8:15 #10. Sumo Goblet Squat Pulses 9:01 #absworkout #flatstomach #bellyfat

 

 

 

 

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