A study found brief exposure to diesel exhaust fumes altered functional connectivity in a human brain in ways researchers suggest could affect cognitive function..Depositphotos
Researchers in Canada have, for the first time ever, demonstrated how acute exposure to traffic pollution can immediately impair human brain function, offering unique evidence of the connection between air quality and cognition. Healthy adults were exposed to diesel fumes before having their brain activity imaged in a fMRI machine.
Air pollution in urban environments has long been associated with poor cardiovascular, respiratory and brain health. But connecting the dots between air quality and human health has been challenging for researchers. It’s difficult to accurately quantify a person’s exposure to air pollution beyond associating rates of certain diseases in geographical areas of high pollution.
Plenty of cell and animal studies can demonstrate how air pollution affects organisms. But as we know, there can often be a huge chasm between the effects of toxins on a mouse in a lab and chronic exposure to a human in the real world.
So perhaps the final missing piece in the puzzle for researchers has been direct human exposure studies. Of course, it’s not exactly ethical to expose volunteers to high levels of toxic fumes just to watch what happens, so these kinds of experiments, unsurprisingly, have been lacking.
This new research used a model of human exposure to diesel exhaust fumes developed over a decade ago. The technique delivers controlled and diluted concentrations of diesel exhaust particulate matter to human subjects at levels deemed to be representative of real-world exposure but also proven to be safe. In a lab setting, 25 healthy adults were exposed to either diesel exhaust, or filtered air for two hours and had their brain activity measured using fMRI before and after each exposure.
The main focus of the study was on the impact of this kind of traffic-associated air pollution on what is known as the default mode network (DMN). This is a set of inter-connected cortical brain regions that play a crucial role in cognition, memory and emotion.
The findings revealed brief exposure to diesel exhaust caused a decrease in DMN activity, essentially yielding a drop in functional connectivity between different brain regions, compared to what was seen when subjects were exposed to filtered air. Jodie Gawryluk, first author on the study, said these kinds of DMN alterations have been linked to depression and cognitive decline.
“We know that altered functional connectivity in the DMN has been associated with reduced cognitive performance and symptoms of depression, so it’s concerning to see traffic pollution interrupting these same networks,” said Gawryluk. “While more research is needed to fully understand the functional impacts of these changes, it’s possible that they may impair people’s thinking or ability to work.”
Alone, these new findings are not particularly meaningful. No evaluations were performed in the study to suggest the observed DMN changes impacted cognition. But alongside a growing body of epidemiological and preclinical studies linking air pollution with a number of neurodegenerative diseases, these findings may be much more significant. They effectively demonstrate the acute effects of air pollution on the human brain in a way never before shown.
According to senior author on the study Chris Carlsten, it is unclear what long-term effects this kind of pollution exposure will have on a human brain. On the positive side of things the researchers did seen DMN brain activity return to normal relatively soon after the diesel fume exposure. So Carlsten is only able to hypothesize what the impact of more chronic, continuous exposure could be.
“People may want to think twice the next time they’re stuck in traffic with the windows rolled down,” said Carlsten. “It’s important to ensure that your car’s air filter is in good working order, and if you’re walking or biking down a busy street, consider diverting to a less busy route.”
Rich has written for a number of online and print publications over the last decade while also acting as film critic for several radio broadcasters and podcasts. His interests focus on psychedelic science, new media, and science oddities. Rich completed his Masters degree in the Arts back in 2013 before joining New Atlas in 2016.
Whether it’s taking fruit to work (and to the bedroom!), being polite to rude strangers or taking up skinny-dipping, here’s a century of ways to make life better, with little effort involved …
1 Exercise on a Monday night (nothing fun happens on a Monday night).
2 On the fence about a purchase? Wait 72 hours before you buy it.
3 Tip: the quickest supermarket queue is always behind the fullest trolley (greeting, paying and packing take longer than you think).
4 Bring fruit to work. Bring fruit to bed!
5 Consider going down to four days a week. It’s likely a disproportionate amount of your fifth day’s work is taxed anyway, so you’ll lose way less than a fifth of your take-home pay.
6 Everyone has an emotional blind spot when they fight. Work out what yours is, and remember it.
7 Plant spring bulbs, even if they’re just in a pot.
8 Send a voice note instead of a text; they sound like personal mini podcasts.
9 Keep a bird feeder by a window, ideally the kitchen. It’ll pass the time when you’re washing up.
10 Always bring ice to house parties (there’s never enough).
11 Get the lighting right: turn off the overhead one, turn on lots of lamps (but turn off when you leave the room).
12 Sharpen your knives.
13 Feeling sluggish at work? Try the Pomodoro technique: 25 minutes on, five-minute break, and repeat.
14 Buy a cheap blender and use it to finely chop onions (it saves on time and tears).
15 Keep your children’s drawings and paintings. Put the best ones in frames.
16 Set aside 10 minutes a day to do something you really enjoy – be it reading a book or playing Halo.
17 Don’t be weird about how to stack the dishwasher.
18 Reuse all plastic bags – even bread bags. Much of the packaging you can’t reuse can be taken to larger branches of supermarkets for recycling.
19 Take a photo of the tag you are given when leaving your coat in a cloakroom.
20 Can’t sleep? Try a relaxing soak with lavender bath oil before bed.
21 Add the milk at least one minute after the tea has brewed.
22 Laugh shamelessly at your own jokes.
23 It might sound obvious, but a pint of water before bed after a big night avoids a clanger of a hanger.
24 Start a Saturday morning with some classical music – it sets the tone for a calm weekend.
25 Look closely.
26 Set time limits for your apps. Just go to the settings on your smartphone and add a limit – for example, if you have an iPhone turn on Screen Time.
27 If possible, take the stairs.
28 Always be willing to miss the next train.
29 Eat meat once a week, max. Ideally less.
30 Be polite to rude strangers – it’s oddly thrilling.
31 Ask questions, and listen to the answers.
32 Connect with nature: stand outside barefoot for a few minutes – even when it’s cold.
33 Join your local library – and use it. Find yours here.
34 Go for a walk without your phone.
35 Eat salted butter (life’s too short for unsalted).
36 Stretch in the morning. And maybe in the evening.
37 If you’re going less than a mile, walk or cycle. About half of car journeys are under two miles, yet these create more pollution than longer journeys as the engine isn’t warmed up yet.
38 Sleep with your phone in a different room (and buy an alarm clock).
39 Send postcards from your holidays. Send them even if you’re not on holiday.
40 Instead of buying new shoes, get old ones resoled and buy new laces.
41 Buy a plant. Think you’ll kill it? Buy a fake one.
42 Don’t have Twitter on your phone.
43 If you find an item of clothing you love and are certain you will wear for ever, buy three.
44 Try taking a cold shower (30 seconds to two minutes) before your hot one. It’s good for your health – both physical and mental.
54 Always bring something – wine, flowers – to a dinner/birthday party, even if they say not to.
55 Learn the names of 10 trees.
56 Call an old friend out of the blue.
57 Every so often, search your email for the word “unsubscribe” and then use it on as many as you can.
58 Buy a newspaper. (Ideally this one.)
59 Always have dessert.
60 Drop your shoulders.
61 Make something from scratch. Works best if it’s something you’d normally buy, such as a dress or a bag.
62 Go to bed earlier – but don’t take your phone with you.
63 Volunteer. Go to gov.uk/government/get-involved for ideas.
64 Dry your cutlery with a cloth (it keeps it shiny).
65 Instead of buying a morning coffee, set up a daily transfer of £2 from a current into a savings account and forget about it. Use it to treat yourself to something different later.
66 Don’t save things for “best”. Wear them – enjoy them.
67 Sing!
68 Think about your posture: don’t slouch, and don’t cross your legs.
69 Hang your clothes up. Ideally on non-wire hangers (it’s better for them).
70 Skinny-dip with friends.
71 Switch your phone off on holiday (or at least delete your work email app).
72 Always use freshly ground pepper.
73 Thank a teacher who changed your life.
74 Respect your youngers.
75 Keep your keys in the same place.
76 Ditch the plastic cartons and find a milkman – The Modern Milkman has a comprehensive list.
77 Rent rather than buy a suit/dress for that forthcoming wedding (even if it’s your own).
78 Always book an extra day off after a holiday.
79 Ignore the algorithm – listen to music outside your usual taste.
80 Mute or leave a WhatsApp group chat.
81 Learn a TikTok dance (but don’t post it on TikTok).
82 Cook something you’ve never attempted before.
83 Join a local litter-picking group.
84 Handwash that thing you’ve never cleaned.
85 Don’t get a pet/do get a pet.
86 Nap.
87 Learn how to breathe deeply: in through the nose, out through the mouth, making the exhale longer than the inhale.
88 Buy a bike and use it. Learn how to fix it, too.
89 Politely decline invitations if you don’t want to go.
90 If you do go, have an exit strategy (can we recommend a French exit, where you slip out unseen).
91 If in doubt, add cheese.
92 Don’t look at your phone at dinner.
93 Do that one thing you’ve been putting off.
94 Give compliments widely and freely.
95 Set up an affordable standing order to a charity. RNLI and Greenpeace spring to mind …
96 Keep a book in your bag to avoid the temptation to doomscroll.
97 Listen to the albums you loved as a teenager.
98 Make a friend from a different generation.
99 Staying over at a friend’s place? Strip the bed in the morning.
100 For instant cheer, wear yellow.
This article was inspired by a similar exercise in Weekend magazine in January 2000. See the original list at theguardian.com/100-tips-from-2000
A new study in Nature Sustainability incorporates the damages that climate change does to healthy ecosystems into standard climate-economics models. The key finding in the study by Bernardo Bastien-Olvera and Frances Moore from the University of California at Davis:
The models have been underestimating the cost of climate damages to society by a factor of more than five. Their study concludes that the most cost-effective emissions pathway results in just 1.5 degrees Celsius (2.7 degrees Fahrenheit) additional global warming by 2100, consistent with the “aspirational” objective of the 2015 Paris Climate Agreement.
Models that combine climate science and economics, called “integrated assessment models” (IAMs), are critical tools in developing and implementing climate policies and regulations.
In 2010, an Obama administration governmental interagency working group used IAMs to establish the social cost of carbon – the first federal estimates of climate damage costs caused by carbon pollution. That number guides federal agencies required to consider the costs and benefits of proposed regulations.
Economic models of climate have long been criticized by those convinced they underestimate the costs of climate damages, in some cases to a degree that climate scientists consider absurd. Given the importance of the social cost of carbon to federal rulemaking, some critics have complained that the Trump EPA used what they see as creative accounting to slash the government’s estimate of the number. In one of his inauguration day Executive Orders, President Biden established a new Interagency Working Group to re-evaluate the social cost of all greenhouse gases.
IAMs often have long been criticized by those convinced they underestimate the costs of climate damages, in some cases to a degree that climate scientists consider absurd. Perhaps the most prominent IAM is the Dynamic Integrated Climate-Economy (DICE) model, for which its creator, William Nordhaus, was awarded the 2018 Nobel Prize in Economic Sciences.
Judging by DICE, the economically optimal carbon emissions pathway – that is, the pathway considered most cost-effective – would lead to a warming increase of more than 3°C (5.4°F) from pre-industrial temperatures by 2100 (under a 3% discount rate). IPCC has reported that reaching this level of further warming could likely result in severe consequences, including substantial species extinctions and very high risks of food supply instabilities.
In their Nature Sustainability study, the UC Davis researchers find that when natural capital is incorporated into the models, the emissions pathway that yields the best outcome for the global economy is more consistent with the dangerous risks posed by continued global warming described in the published climate science literature.
Accounting for climate change degrading of natural capital
Natural capital includes elements of nature that produce value to people either directly or indirectly. “DICE models economic production as a function of generic capital and labor,” Moore explained via email. “If instead you think natural capital plays some distinct role in economic production, and that climate change will disproportionately affect natural capital, then the economic implications are much larger than if you just roll everything together and allow damage to affect output.”
Bastien-Olvera offered an analogy to explain the incorporation of natural capital into the models: “The standard approach looks at how climate change is damaging ‘the fruit of the tree’ (market goods); we are looking at how climate change is damaging the ‘tree’ itself (natural capital).” In an adaptation of DICE they call “GreenDICE,” the authors incorporated climate impacts on natural capital via three pathways:
The first pathway accounts for the direct influence of natural capital on market goods. Some industries like timber, agriculture, and fisheries are heavily dependent on natural capital, but all goods produced in the economy rely on these natural resources to some degree.
According to GreenDICE, this pathway alone more than doubles the model’s central estimate of the social cost of carbon in 2020 from $28 per ton in the standard DICE model to $72 per ton, and the new economically optimal pathway would have society limit global warming to 2.2°C (4°F) above pre-industrial temperatures by 2100.
The second pathway incorporates ecosystem services that don’t directly feed into market goods. Examples are the flood protection provided by a healthy mangrove forest, or the recreational benefits provided by natural places.
In the study, this second pathway nearly doubles the social cost of carbon once again, to $133 per ton in 2020, and it lowers the most cost-effective pathway to 1.8°C (3.2°F) by 2100. Finally, the third pathway includes non-use values, which incorporate the value people place on species or natural places, regardless of any good they produce. The most difficult to quantify, this pathway could be measured, for instance, by asking people how much they would be willing to pay to save one of these species from extinction.
In GreenDICE, non-use values increase the social cost of carbon to $160 per ton of carbon dioxide in 2020 (rising to about $300 in 2050 and $670 per ton in 2100) and limit global warming to about 1.5°C (2.8°F) by 2100 in the new economically optimal emissions pathway. (Note for economics wonks – the model runs used a 1.5% pure rate of time preference.)
Climate economics findings increasingly reinforce Paris targets
It may come as no surprise that destabilizing Earth’s climate would be a costly proposition, but key IAMs have suggested otherwise. Based on the new Nature Sustainability study, the models have been missing the substantial value of natural capital associated with healthy ecosystems that are being degraded by climate change.
Columbia University economist Noah Kaufman, not involved in the study, noted via email that as long as federal agencies use the social cost of carbon in IAMs for rulemaking cost-benefit analyses, efforts like GreenDICE are important to improving those estimates. According to Kaufman, many papers (including one he authored a decade ago) have tried to improve IAMs by following a similar recipe: “start with DICE => find an important problem => improve the methodology => produce a (usually much higher) social cost of carbon.”
For example, several other papers published in recent years, including one authored by Moore, have suggested that, because they neglect ways that climate change will slow economic growth, IAMs may also be significantly underestimating climate damage costs. Poorer countries – often located in already-hot climates near the equator, with economies relying most heavily on natural capital, and lacking resources to adapt to climate change – are the most vulnerable to its damages, despite their being the least responsible for the carbon pollution causing the climate crisis.
Another recent study in Nature Climate Change updated the climate science and economics assumptions in DICE and similarly concluded that the most cost-effective emissions pathway would limit global warming to less than 2°C (3.6°F) by 2100, without even including the value of natural capital. Asked about that paper, Bastien-Olvera noted, “In my view, the fact that these two studies get to similar policy conclusions using two very different approaches definitely indicates the urgency of cutting emissions.”
Recent economics and climate science research findings consistently support more aggressive carbon emissions efforts consistent with the Paris climate targets.
Wesleyan University economist Gary Yohe, also not involved in the study, agreed that the new Nature Sustainability study “supports growing calls for aggressive near-term mitigation.” Yohe said the paper “provides added support to the notion that climate risks to natural capital are important considerations, especially in calibrating the climate risk impacts of all sorts of regulations like CAFE standards.”
But Yohe said he believes that considering the risks to unique and threatened systems at higher temperatures makes a more persuasive case for climate policy than just attempting to assess their economic impacts. In a recent Nature Climate Change paper, Kaufman and colleagues similarly suggested that policymakers should select a net-zero emissions target informed by the best available science and economics, and then use models to set a carbon price that would achieve those goals.
Their study estimated that to reach net-zero carbon pollution by 2050, the U.S. should set a carbon price of about $50 per ton in 2025, rising to $100 per ton by 2030. However climate damages are evaluated, whether through a more complete economic accounting of adverse impacts or via risk-based assessments of physical threats to ecological and human systems, recent economics and climate science research findings consistently support more aggressive carbon emissions efforts consistent with the Paris climate targets.
CREDIT: PETER AND MARIA HOEY -Plant-based meats claim to offer the sensory experience of real meat at a fraction of the environmental cost. Are they really as green as they say?
Marketed to meat lovers, plant-based burgers like Impossible and Beyond claim to taste like the real thing and to have far lighter environmental footprints. Here’s what the numbers have to say.
If you’re an environmentally aware meat-eater, you probably carry at least a little guilt to the dinner table. The meat on our plates comes at a significant environmental cost through deforestation, greenhouse gas emissions, and air and water pollution — an uncomfortable reality, given the world’s urgent need to deal with climate change.
That’s a big reason there’s such a buzz today around a newcomer to supermarket shelves and burger-joint menus: products that look like real meat but are made entirely without animal ingredients. Unlike the bean- or grain-based veggie burgers of past decades, these “plant-based meats,” the best known of which are Impossible Burger and Beyond Meat, are marketed heavily toward traditional meat-eaters. They claim to replicate the taste and texture of real ground meat at a fraction of the environmental cost.
If these newfangled meat alternatives can fill a large part of our demand for meat — and if they’re as green as they claim, which is not easy to verify independently — they might offer carnivores a way to reduce the environmental impact of their dining choices without giving up their favorite recipes.
That could be a game-changer, some think. “People have been educated a long time on the harms of animal agriculture, yet the percentage of vegans and vegetarians generally remains low,” says Elliot Swartz, a scientist with the Good Food Institute, an international nonprofit organization that supports the development of alternatives to meat. “Rather than forcing people to make behavior changes, we think it will be more effective to substitute products into their diets where they don’t have to make a behavior switch.”
There’s no question that today’s meat industry is bad for the planet. Livestock account for about 15 percent of global greenhouse gas emissions both directly (from methane burped out by cattle and other grazing animals and released by manure from feedlots and pig and chicken barns) and indirectly (largely from fossil fuels used to grow feed crops). Indeed, if the globe’s cattle were a country, their greenhouse gas emissions alone would rank second in the world, trailing only China.
Worse yet, the United Nations projects that global demand for meat will swell by 15 percent by 2031 as the world’s increasing — and increasingly affluent — population seeks more meat on their plates. That means more methane emissions and expansion of pastureland and cropland into formerly forested areas such as the Amazon — deforestation that threatens biodiversity and contributes further to emissions.
Global demand for meat continues to rise with little sign of slowing. Much of the increase comes from middle-income countries, where consumers use their increasing wealth to put more meat on their plates.
Not all kinds of meat animals contribute equally to the problem, however. Grazing animals such as cattle, sheep and goats have a far larger greenhouse gas footprint than non-grazers such as pigs and chickens. In large part that’s because only the former burp methane, which happens as gut microbes digest the cellulose in grasses and other forage.
Pigs and chickens are also much more efficient at converting feed into edible flesh: Chickens need less than two pounds of feed, and pigs need roughly three to five pounds, to put on a pound of body weight. (The rest goes to the energy costs of daily life: circulating blood, moving around, keeping warm, fighting germs and the like.) Compare that to the six to 10 pounds of feed per pound of cow.
As a result, the greenhouse gas emissions of beef cattle per pound of meat are more than six times those of pigs and nearly nine times those of chicken. (Paradoxically, grass-fed cattle — often thought of as a greener alternative to feedlot beef — are actually bigger climate sinners, because grass-fed animals mature more slowly and thus spend more months burping methane.)
Building fake meat
Plant-based meats aim to improve on that dismal environmental performance. Stanford University biochemist Pat Brown, for example, founded Impossible Foods after asking himself what single step he could take to make the biggest difference environmentally. His answer: Replace meat.
Researchers trawled through the scientific literature to find every available study measuring the greenhouse-gas footprint of meats and meat alternatives. Beef is by far the most emissions-heavy option, while plant-based meats and plant foods generally are linked to much lower levels of greenhouse gas emissions for production of a given quantity of protein. In the chart, (n) refers to the number of studies for each category of protein.
To do that, Impossible and its competitors basically deconstruct meat into its component parts, then build an equivalent product from plant-based ingredients. The manufacturers start with plant protein — mostly soy for Impossible, pea for Beyond, and potato, oat or equivalent proteins for others — and add carefully selected ingredients to simulate meat-like qualities. Most include coconut oil for its resemblance to the mouthfeel of animal fats, and yeast extract or other flavorings to add meaty flavors. Impossible even adds a plant-derived version of heme, a protein found in animal blood, to yield an even more meat-like appearance and flavor.
All this requires significant processing, notes William Aimutis, a food protein chemist at North Carolina State University, who wrote about plant-based proteins in the 2022 Annual Review of Food Science and Technology. Soybeans, for example, are typically first milled into flour, and then the oils are removed. The proteins are isolated and concentrated, then pasteurized and spray-dried to yield the relatively pure protein for the final formulation. Every step consumes energy, which raises the question: With all this processing, are these meat alternatives really greener than what they seek to replace?
To answer that question, environmental scientists conduct what’s known as a life cycle analysis. This involves taking each ingredient in the final product — soy protein, coconut oil, heme and so forth — and tracing it back to its origin, logging all the environmental costs involved. In the case of soy protein, for example, the life cycle analysis would include the fossil fuels, water and land needed to grow the soybeans, including fossil fuel emissions from the fertilizer, pesticides and transportation to the processing plant. Then it would add the energy and water consumed in milling, defatting, protein extraction and drying.
Similar calculations would apply to all the other ingredients, and to the final process of assembly and packaging. Put it all together, and you end up with an estimate of the total environmental footprint of the product.
Plant-based meats are highly processed products in which proteins, fats, starches, thickeners, flavoring agents and other ingredients are mixed and formed into foods that resemble traditional meat products such as burgers, hot dogs and chicken nuggets.
Unfortunately, not all those numbers are readily available. For many products, especially unique ones like the new generation of plant-based meats, product details are secrets closely held by the companies involved. “They will know how much energy they use and where they get their fat and protein from, but they will not disclose that to the general public,” says Ricardo San Martin, a chemical engineer who codirects the Alternative Meats Lab at the University of California, Berkeley. As a result, most life cycle analyses of plant-based meat products have been commissioned by the companies themselves, including both Beyond and Impossible. Outsiders have little way of independently verifying them.
Even so, those analyses suggest that plant-based meats offer clear environmental advantages over their animal-based equivalents. Impossible’s burger, for example, causes just 11 percent of the greenhouse gas emissions that would come from an equivalent amount of beef burger, according to a study the company commissioned from the sustainability consulting firm Quantis. Beyond’s life cycle analysis, conducted by researchers at the University of Michigan, found their burger’s greenhouse gas emissions were 10 percent of those of real beef.
Indeed, when independent researchers at Johns Hopkins University decided to get the best estimates they could by combing through the published literature, they found that in the 11 life cycle analyses they turned up, the average greenhouse gas footprint from plant-based meats was just 7 percent of beef for an equivalent amount of protein. The plant-based products were also more climate-friendly than pork or chicken — although less strikingly so, with greenhouse gas emissions just 37 percent and 57 percent, respectively, of those for the actual meats.
Similarly, the Hopkins team found that producing plant-based meats used less water: 23 percent that of beef, 11 percent that of pork and 24 percent that of chicken for the same amount of protein. There were big savings, too, for land, with the plant-based products using 2 percent that of beef, 18 percent that of pork and 23 percent that of chicken for a given amount of protein. The saving of land is important because, if plant-based meats end up claiming a significant market share, the surplus land could be allowed to revert to forest or other natural vegetation; these store carbon dioxide from the atmosphere and contribute to biodiversity conservation. Other studies show that plant-based milks offer similar environmental benefits over cow’s milk (see Box).
Researchers compared the amount of land needed to produce a given amount of protein for meat, plant-based meat and plant foods. Once again, beef towers above the rest, largely because grazing animals need a lot of land to forage. Plant foods are shown to require more land than plant-based meats, but this difference is not meaningful because the estimates for plant foods include crops grown in low-yielding countries, while plant-based meats rely on ingredients grown under high-yield conditions.
A caution on cultivation methods
Of course, how green plant-based meats actually are depends on the farming practices that underlie them. (The same is true for meat itself — the greenhouse gas emissions generated by a pound of beef can vary more than tenfold from the most efficient producers to the least.) Plant-based ingredients such as palm oil grown in plantations that used to be rainforest, or heavily irrigated crops grown in arid regions, cause much more damage than more sustainably raised crops. And cultivation of soybeans, an important ingredient for some plant-based meats, is a major contributor to Amazon deforestation.
However, for most ingredients it seems likely that even poorly produced plant-based meats are better, environmentally, than meat from well-raised livestock. Plant-based meats need much less soy than would be fed to actual livestock, notes Matin Qaim, an agricultural economist at the University of Bonn, Germany, who wrote about meat and sustainability in the 2022 Annual Review of Resource Economics. “The reason we’re seeing deforestation in the Amazon,” he explains, “is because the demand for food and feed is growing. When we move away from meat and more toward plant-based diets, we need less area in total, and the soybeans don’t necessarily have to grow in the Amazon.”
But green as they are, plant-based meats have a few hurdles to clear before they can hope to replace meat. For one thing, plant-based meats currently cost an average of 43 percent more than the products they hope to replace, according to the Good Food Institute. That helps to explain why plant-based meats account for less than 1 percent of meat sales in the US. Advocates are optimistic that the price will come down as the market develops, but it hasn’t happened yet. And achieving those economies of scale will take a lot of work: Even growing to a mere 6 percent of the market will require a $27 billion investment in new facilities, says Swartz.
Steak hasn’t yet been well done
In addition, all of today’s plant-based meats seek to replace ground-meat products like burgers and chicken nuggets. Whole-muscle meats like steak or chicken breast have a more complex, fibrous structure that the alt-meat companies have not yet managed to mimic outside the lab.
Part of the problem is that most plant proteins are globular in shape, while real muscle proteins tend to form long fibers. To form a textured meat-like product, scientists essentially have to turn golf balls into string, says David Julian McClements, a food scientist at the University of Massachusetts, Amherst, and an editor of the Annual Review of Food Science and Technology. There are ways to do that, often involving high-pressure extrusion or other complex technology, but so far no one has a whole-muscle product ready for market. (A fungal product, sold for decades in some countries as Quorn, is naturally fibrous, but its sales have never taken off in the US. Other companies are also working on meat substitutes based on fungal proteins.)
The environmental impact of the two leading plant-based burgers, from Impossible Foods and Beyond Meat, is much less than a comparable beef burger, according to detailed studies commissioned by the two companies. Other experts note that these studies are difficult to verify independently because they rely on proprietary information from the companies.
McClements is experimenting with another approach to make plant-based bacon: creating separate plant-based analogs of muscle and fat, then 3D-printing the distinctive marbling of the bacon. “I think we’ve got all the elements to put it together,” he says.
Some critics also note that a shift toward plant-based meat may reinforce the industrialization of global food systems in an undesirable way. Most alternative meat products are formulated in factories, and their demand for plant proteins and other ingredients favors Big Agriculture, with its well-documented problems of monoculture, pesticide use, soil erosion and water pollution from fertilizer runoff. Plant-based meats will reduce the impact of these unsustainable farming practices, but they won’t eliminate them unless current farming practices change substantially.
Of course, all the to-do about alternative meats overlooks another dietary option, one with the lowest environmental footprint of all: Simply eat less meat and more beans, grains and vegetables. The additional processing involved in plant-based meats means that they generate 4.6 times more greenhouse gas than beans, and seven times more than peas, per unit of protein, according to the Hopkins researchers. Even traditional, minimally processed plant protein such as tofu beats plant-based meats when it comes to greenhouse gas. Moreover, most people in wealthy countries eat far more protein than they need, so they can simply cut back on their protein consumption without seeking out a replacement.
But that option may not appeal to the meat-eating majority today, which makes alternative meats a useful stopgap. “Would I prefer that people were eating beans and grains and tofu, and lots of fruits and vegetables? Yes,” says Bonnie Liebman, director of nutrition at the Center for Science in the Public Interest, an advocacy organization supporting healthy eating.
“But there are a lot of people who enjoy the taste of meat and are probably not going to be won over by tofu. If you can win them over with Beyond Meat, and that helps reduce climate change, I’m all for it.”
The team at the Francis Crick Institute in London showed that rather than causing damage, air pollution was waking up old damaged cells. One of the world’s leading experts, Prof Charles Swanton, said the breakthrough marked a “new era”. And it may now be possible to develop drugs that stop cancers forming. The findings could explain how hundreds of cancer-causing substances act on the body.
The classical view of cancer starts with a healthy cell. It acquires more and more mutations in its genetic code, or DNA, until it reaches a tipping point. Then it becomes a cancer and grows uncontrollably. But there are problems with this idea: cancerous mutations are found in seemingly healthy tissue, and many substances known to cause cancer – including air pollution – don’t seem to damage people’s DNA.
So what is going on?
The researchers who also work at University College London, have produced evidence of a different idea. The damage is already there in our cell’s DNA, picked up as we grow and age, but something needs to pull the trigger that actually makes it cancerous.
The discovery came from exploring why non-smokers get lung cancer. The overwhelming majority of lung cancers are caused by smoking but still, one in 10 cases in the UK is down to air pollution. The Crick scientists focused on a form of pollution called particulate matter 2.5 (known as PM2.5), which is far smaller than the diameter of a human hair.
Through a series of detailed human and animal experiments they showed:
Places with higher levels of air pollution had more lung cancers not caused by smoking
Breathing in PM2.5 leads to the release of a chemical alarm – interleukin-1-beta – in the lungs
This causes inflammation and activates cells in the lungs to help repair any damage
But around one in every 600,000 cells in the lungs of a 50-year-old already contains potentially cancerous mutations
These are acquired as we age but appear completely healthy until they are activated by the chemical alarm and become cancerous
Crucially, the researchers were able to stop cancers forming in mice exposed to air pollution by using a drug that blocks the alarm signal. The results are a double breakthrough, both for understanding the impact of air pollution and the fundamentals of how we get cancer.
Dr Emilia Lim, one of the researchers who is based at the Crick and UCL, said people who had never smoked but developed lung cancer often had no idea why. “To give them some clues about how this might work is really, really important,” she said. “It’s super-important – 99% of people in the world live in places where air pollution exceeds the WHO guidelines so it really impacts all of us.”
Rethinking cancer
But the results also showed mutations alone are not always enough to cause cancer. It can need an extra element. Prof Swanton said this was the most exciting finding his lab had come across, as it “actually rethinks our understanding of how tumours are initiated”. He said it would lead to a “new era” of molecular cancer prevention.
The idea of taking a cancer-blocking pill if you live in a heavily polluted area is not completely fanciful. Doctors have already trialled an interleukin-1-beta drug in cardiovascular disease and found, by complete accident, they cut the risk of lung cancer. The latest findings are being presented to scientists at a conference of the European Society for Medical Oncology.
Speaking to the BBC from the conference, Prof Swanton said: “Pollution is a lovely example, but there are going to be 200 other examples of this over the next 10 years.”
And he said we needed to rethink how even smoking causes cancer – is it just the known DNA damage caused by the chemicals in tobacco or is the smoke causing inflammation, too? Curiously, the idea that mutated DNA is not enough and cancers need another trigger to grow was first proposed by scientist Isaac Berenblum in 1947.
“Philosophically, it’s fascinating. These incredible biologists have done this work 75 years ago and it’s largely been ignored,” said Dr Lim. Michelle Mitchell, chief executive of Cancer Research UK, stressed that “smoking remains the biggest cause of lung cancer”.
But she added: “Science, which takes years of painstaking work, is changing our thinking around how cancer develops. We now have a much better understanding of the driving forces behind lung cancer.”
A new mechanism has been identified through which very small pollutant particles in the air may trigger lung cancer in people who have never smoked, paving the way to new prevention approaches and development of therapies, according to late-breaking data [to be] reported at the ESMO Congress 2022 by scientists of the Francis Crick Institute and University College London, funded by Cancer Research UK.
The particles, which are typically found in vehicle exhaust and smoke from fossil fuels, are associated with non-small cell lung cancer (NSCLC) risk, accounting for over 250,000 lung cancer deaths globally per year. “The same particles in the air that derive from the combustion of fossil fuels, exacerbating climate change, are directly impacting human health via an important and previously overlooked cancer-causing mechanism in lung cells.
The risk of lung cancer from air pollution is lower than from smoking, but we have no control over what we all breathe. Globally, more people are exposed to unsafe levels of air pollution than to toxic chemicals in cigarette smoke, and these new data link the importance of addressing climate health to improving human health,” said Charles Swanton, the Francis Crick Institute and Cancer Research UK Chief Clinician, London, UK, who will present the research results at the ESMO 2022 Presidential Symposium on Saturday, 10 September.
The new findings are based on human and laboratory research on mutations in a gene called EGFR which are seen in about half of people with lung cancer who have never smoked. In a study of nearly half a million people living in England, South Korea and Taiwan, exposure to increasing concentrations of airborne particulate matter (PM) 2.5 micrometres (μm) in diameter was linked to increased risk of NSCLC with EGFR mutations.
In the laboratory studies, the Francis Crick Institute scientists showed that the same pollutant particles (PM2.5) promoted rapid changes in airway cells which had mutations in EGFR and in another gene linked to lung cancer called KRAS, driving them towards a cancer stem cell like state. They also found that air pollution drives the influx of macrophages which release the inflammatory mediator, interleukin-1β, driving the expansion of cells with the EGFR mutations in response to exposure to PM2.5, and that blockade of interleukin-1β inhibited lung cancer initiation.
These findings were consistent with data from a previous large clinical trial showing a dose dependent reduction in lung cancer incidence when people were treated with the anti-IL1β antibody, canakinumab. In a final series of experiments, the Francis Crick team used state-of-the-art, ultradeep mutational profiling of small samples of normal lung tissue and found EGFR and KRAS driver mutations in 18% and 33% of normal lung samples, respectively.
“We found that driver mutations in EGFR and KRAS genes, commonly found in lung cancers, are actually present in normal lung tissue and are a likely consequence of ageing. In our research, these mutations alone only weakly potentiated cancer in laboratory models. However, when lung cells with these mutations were exposed to air pollutants, we saw more cancers and these occurred more quickly than when lung cells with these mutations were not exposed to pollutants, suggesting that air pollution promotes the initiation of lung cancer in cells harbouring driver gene mutations.
The next step is to discover why some lung cells with mutations become cancerous when exposed to pollutants while others don’t,” said Swanton. Commenting on the results, Tony Mok, Chinese University of Hong Kong, not involved in the study, said: “This research is intriguing and exciting as it means that we can ask whether, in the future, it will be possible to use lung scans to look for pre-cancerous lesions in the lungs and try to reverse them with medicines such as interleukin-1β inhibitors.
We don’t yet know whether it will be possible to use highly sensitive EGFR profiling on blood or other samples to find non-smokers who are predisposed to lung cancer and may benefit from lung scanning, so discussions are still very speculative.” Like Swanton, he stresses the importance of reducing air pollution to lower the risk of lung diseases, including cancer.
“We have known about the link between pollution and lung cancer for a long time, and we now have a possible explanation for it. As consumption of fossil fuels goes hand in hand with pollution and carbon emissions, we have a strong mandate for tackling these issues – for both environmental and health reasons,” Mok concluded.