ChatGPT Won’t Fix Healthcare, But It Might Save Doctors Some Time

Nicolas Ortega for forbes

Every week, Eli Gelfand, chief of general cardiology at Beth Israel Deaconess Medical Center in Boston, wastes a lot of time on letters he doesn’t want to write — all of them to insurers disputing his recommendations. A new drug for a heart failure patient. A CAT scan for a patient with chest pain. A new drug for a patient with stiff heart syndrome. “We’re talking about appeal letters for things that are life-saving,” says Gelfand, who is also an assistant professor at Harvard Medical School.

So when OpenAI’s ChatGPT began making headlines for generally coherent artificial intelligence-generated text, Gelfand saw an opportunity to save some time. He fed the bot some basic information about a diagnosis and the medications he’d prescribed (leaving out the patient’s name) and asked it to write an appeal letter with references to scientific papers.

ChatGPT gave him a viable letter — the first of many. And while the references may sometimes be wrong, Gelfand told Forbes the letters require “minimal editing.” Crucially, they have cut the time he spends writing them down to a minute on average. And they work.

Gelfand has used ChatGPT for some 30 appeal letters, most of which have been approved by insurers, he says. But he’s under no illusion that ChatGPT or the AI that powers it is going to save the U.S. healthcare system anytime soon. “It’s basically making my life a little easier and hopefully getting the patients the medications they need at a higher rate,” Gelfand says. “This is a workaround solution for a problem that shouldn’t really exist.”

That problem: The U.S. spends more money on healthcare administration than any other country. In 2019, around a quarter of the $3.8 trillion spent on healthcare went to administrative issues like the ones bemoaned by Gelfand. It’s estimated around $265 billion of that was “wasteful” — unnecessary expenditures necessitated by the antiquated technology that undergirds the U.S. healthcare system.

Gelfand can use a chatbot to electronically generate an appeal letter. But he has to fax it to the insurer. And that encapsulates the challenge facing companies hoping to build time-saving AI back-office tools for a healthcare system stuck in the 1960s.

Cut The “Scut”

The fax machine isn’t going away anytime soon, says Nate Gross, cofounder and chief strategy officer of Doximity, a San Francisco-based social networking platform used by two million doctors and other healthcare professionals in the U.S. That’s why Doximity’s new workflow tool, DocsGPT, a chatbot that helps doctors write a wide range of letters and certificates, is connected to its online faxing tool.

“Our design thesis is to make it as easy as possible for doctors to interface with the novel digital standards, but also be backwards compatible with all the old stuff that healthcare actually runs on,” says Gross.

Often referred to as a “LinkedIn For Doctors,” Doximity has a $6.3 billion market cap and generates most of its revenue ($344 million in its fiscal year 2022) from pharma companies looking to advertise and health systems looking to hire. But it also offers a range of tools for doctors to help “cut through the scut” – medical slang for reducing administrative burden. The basic versions are generally free with upsells for enterprise integrations, says Gross.

DocsGPT is built on ChatGPT but is trained on healthcare data, such as anonymized insurance appeals letters. Doctors can use the tool to draft letters, including patient referrals, insurance appeals, thank you notes to colleagues, post-surgery instructions and even death certificates. It provides a library of curated prompts based on what other doctors have searched for in the past, and is designed to remind doctors who use it that it is not a medical professional.

Before each response DocsGPT generates, a disclaimer runs across the top, asking the user to “PLEASE EDIT FOR ACCURACY BEFORE SENDING.” In an earnings call earlier this month, cofounder and CEO Jeff Tangney was asked how Doximity planned to monetize DocsGPT. “I’ll make a joke here,” he replied. “We probably spent more time worrying about the liability of that product than the monetization of it so far.”

Bot-To-Bot

While DocsGPT might save some time for the doctor, the subsequent back and forth with insurance companies over fax and phone means it can still take days to verify a patient’s insurance benefits or get a prior authorization for a surgery approved. Currently, a person in a doctor’s office or hospital staring at a screen needs to call a person at an insurance company who is also staring at a screen to manually sort through the specific details of each patient’s insurance benefits.

That eats up a lot of time for both insurers and doctors, and a shortage of workers isn’t helping, “It’s not just about it being slow, it’s stuff is not getting done,” says Ankit Jain, cofounder and CEO of conversational AI startup Infinitus Systems. “There was [an insurer] we were talking to who had 32 trailers of faxes that they’re backlogged on.”

With Infinitus, which raised more than $50 million since he cofounded it in 2019, Jain is trying to build a future where instead of people endlessly discussing benefits and approvals, bots do the talking for them.

“When a doctor makes stuff up, that’s called lying. When a model makes stuff up, we use this odd phrase called hallucination.”

Jain, a former Googler and cofounder of the tech giant’s AI-focused fund Gradient Ventures, says the problem is that every doctor, insurer and health system records information in different formats. Unlike long-suffering health industry employees, AI can very quickly make sense of it. Infinitus has built its own models and doesn’t rely on OpenAI’s technology, but Jain says the underlying premise is the same: “What large language models do is, they say, ‘Throw all that data at us.’ And the large language models can extract the right connections between phrases and concepts.”

So far, the conversation is one-sided: Infinitus used large language models to create Eva Lightyear, a robot that has made more than 1 million calls to insurance companies on behalf of doctors to verify insurance benefits and prior authorization requirements. One day, he hopes Eva won’t be calling a human on the other end of the phone, but another robot — though not literally.

“It’s not robots talking to robots in English or exchanging faxes with each other,” says Jain. “That becomes an API. The future needs to be digital highways, where you just submit information, it’s judged, it’s adjudicated, and you get a response instantaneously.”

Crawling Ahead

While Jain may be optimistic about end-to-end automation, when it comes to adoption, chatbots and other kinds of AI-powered technology are facing a serious hurdle: Models like ChatGPT spout falsities as if they were true and have to be constantly retrained with the most up-to-date information out there.

“When a doctor makes stuff up, that’s called lying. When a model makes stuff up, we use this odd phrase called hallucination,” says Nigam Shah, chief data scientist at Stanford Healthcare.

ChatGPT was only trained on data available until 2021, and isn’t regularly updated. The field of medicine is constantly changing, with new guidelines, drugs and devices coming on the market, which means outdated data would pose a problem. Shah says he doesn’t see the possibility for broad adoption of generative AI in healthcare until there are systems in place to regularly retrain the models on new information and detect when the answers are wrong.

“We have to figure out how to verify the veracity and truthfulness of the output,” he says. There is also the risk that a doctor, no matter how well-intentioned, enters protected health information into ChatGPT. While anonymization and encryption are two ways to protect patient data, these measures alone may not be enough, says Linda Malek, a partner at the law firm Moses Singer.

“Even if you try to de-identify the data that is stored in ChatGPT, the AI capabilities can re-identify information,” she says. “ChatGPT is a particular target for cyber criminals as well, because it can be utilized for ransomware and different types of cyber attacks.”

Potential dangers aside, generative AI’s achievements continue to wow users. In January, researchers found that ChatGPT could pass the US medical licensing exam with “moderate accuracy” without any special training. (It’s not alone in this – at least two other AI programs, Google’s Flan-PaLM and Chinese AI-powered bot Xiaoyi, have also passed national medical licensing exams.)

The motivation was to get ChatGPT to perform standardized tasks without being specifically trained on any healthcare datasets, says Morgan Cheatham, a vice president at Bessemer Venture Partners and medical student at Brown University, who co-authored the study, which was published in PLOS Digital Health. While Cheatham says the results suggest ChatGPT’s large language models “have inherent value in healthcare applications,” he says any path forward is going to require a “crawl, walk, run approach.”

For now, the hope is generative AI could help doctors bring their attention and time to the most important part of their jobs: their patients. “What got me excited about becoming a doctor was the face-to-face interaction in the exam room with another human being,” says David Canes, a urologist at Beth Israel Lahey Health and cofounder of patient education startup Wellprept. “What’s intruded now is thousands of mouse clicks and keyboard entries.”

Canes says he plans to use ChatGPT for “low-stakes communications,” and he looks forward to the day when he can spend less time dealing with never-ending bureaucracy.

“My days would be perfect if they were just filled with patient care. I love that as much now as I ever did,” he says. “I look at these improvements and it makes me really hopeful that we’re on the verge of maybe a new era where the worst aspects of medicine can be minimized.”

Correction: The research involving ChatGPT taking the U.S. medical licensing exam was published in PLOS Digital Health in February.

I’m a senior writer at Forbes covering healthcare technology. I was previously a healthcare reporter for POLITICO covering the European Union from Brussels and the New Jersey

Rashi Shrivastava

I am an assistant editor based in Columbia, Missouri covering consumer technology. I graduated from the Missouri School of Journalism with a master’s degree in magazine journalism

Source: ChatGPT Won’t Fix Healthcare, But It Might Save Doctors Some Time

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4 Things Aging Experts Do To Live Longer and Feel Better

Mobility training is important for healthy aging because it helps make everyday tasks easier. Image Credit: Jose Luis Pelaez Inc/DigitalVision/GettyImages

When you look into your future, who do you want to see? Someone who’s full of life and chatting everyone up, telling vibrant stories about your past? Still signing up for 10Ks well into your seventh decade? Someone whose doctor tells them they have the heart of someone decades younger?

It’s possible to live longer and feel better if you have the right habits. Here’s what internal medicine doctors, registered dietitians and certified personal trainers do to make sure they age well:

1. ‘I Switch Up My Food’

Variety is the X-factor when it comes to building a healthy diet for longevity, Angel Planells, MD, RDN, a Seattle-based national media spokesperson for the Academy of Nutrition & Dietetics, tells LIVESTRONG.com.

“Consuming a wide variety of foods — whole grains, fruits, vegetables, nuts, seeds, beans, dairy and meat and non-meat protein — helps to fuel my body and have it running like a high-octane sports car,” he says. As Planells explains, variety beats boredom and ensures he’s getting a range of nutrients, including carbohydrates, protein, fat, vitamins and minerals.

That’s on display with his protein choices, where he toggles between chicken, fish, pork and lamb, as well as snacking on nuts and seeds. In addition to being used to build and repair muscles and maintain the strength of your skeleton, protein is also important for the health of hair and nails, too, he says.

2. ‘I Get Some Sort of Movement in Every Day’

Eric Goldberg, MD, clinical associate professor of medicine at NYU Langone Health and senior director of NYU Langone Internal Medicine Associates, heads out for a run first thing in the morning.”Establishing a strong baseline for fitness at a younger age has been shown to lead to healthier aging,” he tells LIVESTRONG.com.

Movement has looked different for him during the pandemic, and he’s had to make adjustments that would benefit his health the most during the changes of the past year. “I started to run more days of the week — but shorter distances — in order to combat the stress of the past year and to have some intentional movement each day, especially with longer days sitting on a screen,” Dr. Goldberg explains.

Not only does this buoy his physical and mental health today, but it protects against the risk of frailty in the future. Frailty is a syndrome where loss of muscle leads to weakness, slowness, poor endurance and a low level of physical activity, per the Medical University of South Carolina. People who have frailty are more likely to fall, be hospitalized and have an increased risk of mortality — but frailty is not inevitable with aging.

The key, Dr. Goldberg says, is to get into the habit so that this daily movement becomes more automatic. “Habits generally take a month to build, so consistency is essential. Once integrated into your routine, they are easier to maintain,” he says.

3. ‘I Commit to Sleep’

One of the best pieces of healthy aging and longevity advice can be the hardest one to follow: Prioritize sleep as best as you can. Brent Agin, MD, founder and medical director at Priority You MD in Clearwater, Florida, aims for 7 to 8 hours per night. “Quality of sleep is more important than quantity in most cases, so I don’t try to achieve a sleep cycle that’s unrealistic,” Dr. Agin tells LIVESTRONG.com.

Sleep, along with a nutrient-packed diet and regular exercise, is what Dr. Agin considers the three essentials for a healthy lifestyle. “Lifestyle is the driving force behind healthy aging,” he says.

If you know you’re lacking the sleep component, a good place to start is to aim to sleep more than six hours and then incrementally add on 15 minutes from there until you get to a duration that feels good to you. Sleeping fewer than six hours per night is associated with a higher risk of death from heart disease, stroke and cancer, according to the ​Journal of the American Heart Association​.

4. ‘I Exercise According to the 3 Pillars’

There is actually no one right way to exercise, but for the most benefit, you should mix it up. “To make sure I’m prepared for healthy aging, I stick to the idea that my training is diverse and it covers the three pillars that I always go by: cardiovascular training for your heart, strength training for bone health and flexibility, and mobility training for balance,” Aleksandra Stacha-Fleming, certified personal trainer and founder of Longevity Lab NYC, tells LIVESTRONG.com.

The end goal isn’t a specific look or body type, but to allow your body to move freely and do what you need it to do. “Everyone who’s active knowns how good it feels to be able to do everyday tasks without being out of breath, such as being strong enough to shovel the snow out of your driveway or carry groceries home from the store,” Stacha-Fleming says. “To simply do the normal stuff of living freely is aging gracefully with strength, and we should work on that every day.”

Source: 4 Things Aging Experts Do to Live Longer and Feel Better | livestrong

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Why You’re Gaining Weight Suddenly, According to Doctors and Dietitians

Photo by Malte Mueller/Getty Images

It’s understandable when you gain a few pounds after vacation or if you break your ankle and spend six weeks propped on the sofa bingeing obscure British cooking shows (and the chocolate scones to go with them).

But when you can’t zip your jeans for no freaking reason at all — you swear you’re not eating any more or exercising any less — it can feel like there’s some dark magic at play. You may find yourself standing on the bathroom scale, screaming into the void:

“Why am I gaining weight?!”

Deep breath. You got this.

Most likely, there’s something in your life that’s shifted just enough to make a difference, but not so much that you’d notice, says Alexandra Sowa, MD, an obesity specialist and clinical instructor of medicine at NYU Langone Health. “I see this all the time — you may not step on the scale for a while, and you feel like you haven’t changed anything, and all of a sudden you go to the doctor’s office and notice you’ve gained 10 or 20 pounds,” she says.

But that doesn’t mean it’s your destiny to go up another size every year. Here are some of the most likely reasons for unexplained weight gain, and how to stop it in its tracks.

Your insulin levels may be out of whack.

If you’ve been battling weight issues for a while and none of your efforts are moving the needle, make an appointment with your primary care doc or a weight-management physician, who can assess you for insulin resistance or prediabetes. (Your doctor can also test you for hypothyroidism, in which your thyroid gland doesn’t produce enough hormone, slowing down your metabolism and potentially leading to weight gain.)

“Insulin is the hormone that signals the body to pull glucose out of the bloodstream and store it in the muscles, liver, and fat,” explains Tirissa Reid, MD, an obesity medicine specialist at Columbia University Medical Center and Diplomate of the American Board of Obesity Medicine. “But when you’re overweight, the cells don’t recognize the insulin as well, so the pancreas has to pump out more and more — sometimes two or three times the normal amount — until the cells respond.”

(This is also common in women who have polycystic ovary syndrome — a condition in which the egg follicles in the ovaries bunch together to form cysts.) These high insulin levels keep the body in storage mode and make weight loss more difficult, says Dr. Reid. The beginning of this road is insulin resistance — when your pancreas is working overtime, but blood sugar levels are still normal.

All that extra work wears out the pancreas until it can barely do the job of keeping the blood sugar in normal range. Left unchecked, insulin resistance can lead to prediabetes, in which blood-sugar levels are slightly elevated; if that’s not treated, you can develop full-blown type-2 diabetes.

What you can do: The most effective way to reverse this trend is to eat a diet low in refined carbs and added sugars, and to become more physically active, since muscles respond better to insulin after exercise, says Dr. Reid.

She recommends either investing in a fitness tracker or simply using the one that comes with your phone. “People hear you need 10,000 steps each day, which sounds intimidating, but you can also use it just to see where you’re at and make doable increases,” Dr. Reid says. “If you’re at 2,000 steps, try to go up to 2,500 a day next week and continue to increase.”

Swapping to foods with a lower glycemic index (GI) — which means they’re digested more slowly, keeping blood-sugar levels steady — is also important for controlling your insulin levels. Dr. Sowa recommends these lower-GI food swaps: riced cauliflower instead of white rice; zucchini spirals or shirataki noodles (made from plant fiber) instead of pasta; and pumpernickel or stone-ground whole wheat bread instead of white bread or bagels.

Stress and exhaustion are throwing you off.

If you’re up at night worrying about your aging parents, your hormonal teens, and the general crappy state of the world, this can affect your metabolism. “Stress and lack of sleep can cause a cascade of hormonal changes that change your metabolism and affect your sense of hunger and fullness,” Dr. Sowa explains.

Stress pumps up the hormones ghrelin and cortisol, which increase your appetite and can make you crave carbs; at the same time, it dials down the hormone leptin, which helps you feel full. Not surprisingly, a recent Swedish study of 3,872 women over 20 years found that the more stressed you are by work, the likely you are to gain weight. Stress also affects your ability to get a good night’s sleep, and we know that lack of sleep can also throw off your metabolism rates and hunger cues.

What you can do: It’s easy — just fix the world and make everyone around you kinder and more sane.

Hm, maybe not. But you can manage your stress by downloading a free app such as Pacifica, (now Sanvello) which can help you work toward personal goals such as thinking positively and decreasing anxiety by sending you meditations and visualizations to do throughout the day. To sleep more soundly, you already know you should put down your phone, computer, and iPad an hour before bedtime, but new research shows that shutting out all light — including that sliver of moon through your window — can help with both sleep and metabolism.

A study at Northwestern University Feinberg School of Medicine found that after subjects spent just one night of sleeping in a room with dim light, insulin levels the next morning were significantly higher than those who slept in complete darkness, potentially affecting metabolism rates. So consider investing in some good blackout curtains.

Your allergy pills are to blame.

“We’re not 100% sure why, but it’s believed that histamines, chemicals produced by your immune system to fight allergens, have a role in appetite control,” says Dr. Reid. That means that “antihistamines may cause you to eat more,” she says. A large study from Yale University confirmed that there is a correlation between regular prescription antihistamine use and obesity. Dr. Reid points out that some antihistamines such as Benadryl also cause drowsiness, which could make you less apt to exercise.

What you can do: If you suffer from seasonal allergies and are constantly taking antihistamines, talk to your allergist about alternative treatments such as nasal steroid sprays, nasal antihistamines (which have less absorption into the bloodstream, and therefore less effect on hunger), leukotriene inhibitors such as Singulair, or allergy shots, suggests Jeffrey Demain, MD, founder of the Allergy Asthma and Immunology Center of Alaska.

He also says that managing your environment — using a HEPA filter, washing your sheets frequently in hot water, keeping pets out of your bedroom — can help reduce the need for allergy meds. While you’re at it, do an inventory of any prescription medications you’re taking that are known to cause weight gain (including certain antidepressants, beta blockers, corticosteroids, and the birth control shot) and discuss with your doctor if there are equally effective alternatives that don’t affect weight, says Dr. Reid.

Your portions are probably bigger than you think.

Anyone who’s ever sat in a vinyl booth staring down a bowl of pasta big enough for a toddler to swim knows that portion sizes in America are ginormous. But research from the University of Liverpool published last year found that after being served large-size meals outside the home, people tend to serve themselves larger portions up to a week later, meaning supersizing appears to be normalized, says Lisa R. Young, PhD, author of Finally Full, Finally Slim.

Even if your home-cooked portions have crept up only 5% over the last few years, that can be an extra 100 calories a day, which adds up to more than 11 pounds a year, says Lawrence Cheskin, MD, chair of nutrition and food studies at George Mason University. And the official measure of what’s a “serving” isn’t helping.

“The FDA standards for how many ‘servings’ are in a package of food are based on how much food people actually eat, not how much you should eat,” Young explains. For example, to reflect the growing appetites of the American people, a serving of ice cream was increased last year from 1/2 cup to 2/3 cup. More realistic, perhaps, but still more calories than many of us need.

Here’s what to do: First, Young suggests you spend a few days getting a reality check on how much food you’re actually eating at each meal. “When you pour the cereal in the bowl in the morning, pour it back into a measuring cup. What you thought was 1 cup might actually be 3 cups, especially if you’re using a large bowl,” she says.

Also, instead of relying on a government agency (or the chef at your favorite restaurant) at to tell you how much to eat, learn to listen to your own body, says Young. “Serve yourself just one modest portion on a small plate, and when you’re done, wait 20 minutes,” she says. It takes that long for the hormones in your belly to reach your brain and tell it you’re full. If you get to 20 minutes and your stomach is grumbling, have a few more bites.

You’re eating the right thing, but at the wrong time.

Let’s say you switched jobs recently, and dinner is now at 9 p.m. instead of 6:30. Or your new habit of streaming Neflix until the wee hours also involves snacking well past midnight. Even if you’re not eating more, per se, this change might account for the extra poundage.

There’s a delicate dance between your circadian rhythm (the way your body and brain respond to the daily cues of daylight and darkness) and your calorie intake that can mean that same sandwich or bowl of fro-yo that you eat at lunchtime may actually cause more of a weight gain when eaten at night.

A 2017 study at Brigham & Women’s Hospital found that when college students ate food closer to their bedtime — and therefore closer to when the sleep-inducing hormone melatonin was released — they had higher percentages of body fat and a higher body-mass index. The researchers theorize that this is because the amount of energy your body uses to digest and metabolize food drops as your inner clock tells it to get ready to snooze.

What you can do: There are a few life hacks to keep the late-night snacking to a minimum. Dr. Sowa suggests you commit to writing down every bite you eat after dinner: “Whether it’s on a sticky pad or on an app, keeping track of what you’re eating, how much you’re eating, and how you’re feeling when you eat it will hold you accountable for the calories, and it will also help you figure out if you’re truly hungry or just bored,” she says.

She also suggests capping off your evening meal with a brain-and-heart-healthy tablespoon of Fish Oil. “It’s a healthy fat that coats your stomach and makes you feel less hungry later,” she says.

Your “healthy” food is packed with calories.

You could be eating the cleanest, most organic, dietitian-approved variety of plant-based, or ethically farmed food, but that doesn’t mean the calories evaporate into pixie dust when they go in your mouth.

And in fact, research has shown that when you’re eating something healthy — avocados, salad, yogurt, whole grains — part of your attention to fullness tends to turn off. “Even when you’re eating healthy foods, you really have to pay attention to your hunger and satiety signals,” says Véronique Provencher, PhD, professor of nutrition at Université Laval in Quebec City, Canada.

“In several studies we have found that when we perceive a food as healthy it creates a bias in our own judgment, and we think (consciously or not) that we can eat more of it, no problem. We think a salad is healthy, so we feel we can eat as much as we want with as many dressings or toppings as we want.”

What you can do First of all, treat eating like going to the theater, and turn your phone off — and turn away from the computer or TV screen. “We have found when you are eating and working on your computer or watching TV or on a screen you are disconnected from hunger and satiety clues,” says Provencher.

Something else that may help, other experts say, is to become more aware of portion sizes and what’s in your food. Try the Weight Watchers app, which helps you sort out questions like which “healthy” yogurts are full of sugar and calories, and how much avocado you should spread on your toast.

Weight loss, health and body image are complex subjects — before deciding to go on a diet, we invite you gain a broader perspective by reading our exploration into the hazards of diet culture.

Your age might be a factor.

Each birthday you celebrate brings on one undeniable change: your basal resting metabolism (the rate at which your body at rest burns the energy you take in from food) slows down. “It’s not a dramatic drop,” says Dr. Cheskin. “But as you age, you’re probably also getting less active and more tired, and your body tends to lose muscle mass, which burns calories more efficiently than fat.”

So even if you’re eating the exact same amount of food as you did when you were younger, your body is simply not burning it off as effectively as it did during the glory days of your 20s.

Here’s what to do: You can only budge your BMR a little, but there are a few things you can do to make the math work in your favor. The first is to build up your calorie-burning muscle, says fitness expert Michele Olson, PhD, a professor of sports science and physical education at Huntingdon College. “Keep up cardio three times a week for 30 minutes, but add challenging weight training on top of that,” she says.

Olson recommends these exercises that can be done at home. Start with what you can do and build up to 2 sets of 12 of each, every other day.

  • Chair squats: Sit of the edge of a chair with arms crossed; stand up and sit back down for one rep.
  • Triceps dips: Sit on the edge of a chair, supporting yourself with your arms, slide off, walking your feet out in front of you a few steps; with knees bent and body below the seat, bend elbows; press up until arms are straight. (Use a chair without wheels!)
  • Push-ups, from your knees, or full push-ups, if you can.

Another metabolism-boosting strategy: Replace some of the carbohydrates in your diet with proteins, which take more energy to digest, therefore burning off more calories through diet-induced thermogenesis, as well as making you feel fuller for longer.

Dr. Sowa suggests you eat about 100 grams of protein over the course of the day, filling your plate with lean chicken, fish, shrimp, or plant-based proteins such as garbanzo beans, tempeh, and edamame, to give your meals more metabolism bang for your buck. This may only add up to a weight loss of a few pounds a year, but combined with exercise, the cumulative effect can be significant, says Dr. Sowa.

Marisa Cohen is a Contributing Editor in the Hearst Health Newsroom, who has covered health, nutrition, parenting, and the arts for dozens of magazines and web sites over the past two decades.

By : Marisa Cohen  Good Housekeeping

Source: Why You’re Gaining Weight Suddenly, According to Doctors and Dietitians

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Mutations In a Father’s Sperm Could Predict Risk of Autism In Children, Study Finds

A new study from the University of California San Diego School of Medicine has found that 'de novo mutations' in a father's sperm can predict the risk of autism in a child (file image)

Mutations in a father’s sperm could predict the risk of a child being diagnosed with autism, a new study suggests. The genetic flaws, known as ‘de novo mutations’, can appear in a child’s DNA through problems with sperm production.

Researchers found that 15 percent of men with autistic children had these disease-causing mutations in their sperm.The team, from the University of California San Diego School of Medicine, says the findings could lead to test in which fathers have their sperm screened to determine their future children’s risk of the developmental disorder.

Autism spectrum disorder (ASD) is a developmental disorder in which sufferers have a hard time communicating and with behavior.It encompasses several conditions – including autism and Asperger’s syndrome – and symptoms can range from mild to severe.

Children are usually diagnosed by age two after they exhibit signs such as reduced eye contact, not responding to their name and performing repetitive movements.According to the Centers for Disease Control and Prevention, about one in 59 children has ASD.

Boys are much more likely – up to four times – to have the condition than girls. Despite decades of research, the causes of ASD remain a mystery. Both genetics and environmental factors are believed to play a role. However, recent studies have suggested that de novo mutations may be the cause of between 10 and 30 percent of ASD cases.

These mutations occur for the first time in a family member as the result of a mutation in the sperm or egg of a parent. For the study, published in the journal Nature Medicine, the team looked at the sperm of eight fathers who had children already diagnosed with ASD.

The sperm was analyzed for mosaicism, a condition in which a person has genetically different sets of cells within their body. ‘While medical textbooks teach us that every cell in the body has an identical copy of DNA, this is fundamentally not correct,’ said first author Dr Martin Breuss, an assistant project scientist at UC San Diego Health Sciences.

‘Mutations occur every time a cell divides, so no two cells in the body are genetically identical.’ Mosaicism occurs in an unborn baby’s early developmental stages after an error in cell division. ‘[It] can cause cancer or can be silent in the body. If a mutation occurs early in development, then it will be shared by many cells within the body,’ said Dr Breuss.

‘But if a mutation happens just in sperm, then it can show up in a future child but not cause any disease in the father.’Disease-causing mutations were found in about 15 percent of the fathers’ sperm cells, the researchers said.

‘My laboratory has a long-standing interest in understanding the origins of pediatric brain disease, and how mutations contributes to disease in a child,’ said co-senior study author Dr Joseph Gleeson, a professor of neuroscience at UC San Diego School of Medicine.

‘We previously showed that mosaicism in a child can lead to diseases like epilepsy. Here, we show that mosaicism in one of parents is at least as important when thinking about genetic counseling.’

The researchers say their findings could be developed into a clinical test that fathers could undergo to test the risk of recurrence in future children or for men who haven’t had children yet but want to know the risk.

By:  Mary Kekatos

Source: Mutations in a father’s sperm could predict risk of autism in children, study finds | Daily Mail Online

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Scots children waiting upwards of four years for autism assessment, figures show The Scottish Herald

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Gluten free   https://jvz4.com/c/202927/296191
GMB Magic  https://jvz2.com/c/202927/377194
Graphic Alta  https://jvz2.com/c/202927/324492/
Heal Your Emptiness   https://jvz6.com/c/202927/384848/
High Converting Emails  https://jvz3.com/c/202927/386305/
HostLegends    https://jvz4.com/c/202927/384755/
Hostley Domain Creator   https://jvz1.com/c/202927/379223/
Human Synthesys Studio  https://jvz8.com/c/202927/367353/
ImageX   https://jvz6.com/c/202927/363237/
IMSyndicator  https://jvz1.com/c/202927/370769
Inboxr   https://jvz2.com/c/202927/312692
Insta Keyword    https://jvz6.com/c/202927/351606/
Instant Website   https://jvz2.com/c/202927/377557
InstantWebsiteBundle          https://jvz6.com/c/202927/377557
iTraffic X  https://jvz2.com/c/202927/320466
keysearch  https://jvz3.com/c/202927/194909
KlickCourse   https://jvz3.com/c/202927/385006/
Klippyo Kreators  https://jvz8.com/c/202927/327447
KoinCart   https://jvz2.com/c/202927/383555/
Leadvalet   https://jvz3.com/c/202927/385580/
Levidio Royal Podcasting   https://jvz6.com/c/202927/384025/
Linkable DFY   https://jvz6.com/c/202927/385873/
Linkomatic  https://jvz2.com/c/202927/380937/
LiteTrading   https://www.litefinance.com/?uid=929237543
Live Your Truth  https://jvz6.com/c/202927/379020
Living An Intentional Life    https://jvzoo.com/c/202927/382455
Living an International Life    https://jvz8.com/c/202927/382455/
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Local Sites   https://jvz4.com/c/202927/380543/
LocalAgencyBox  https://jvz2.com/c/202927/359468
LocalCentric   https://jvz2.com/c/202927/379339/
LocalioAI    https://jvz6.com/c/202927/378310/
MarketAll      https://jvz2.com/c/202927/386971/
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Mech Forex Robot   https://jvz6.com/c/202927/383447/
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Motion Kingdom Studio  https://jvz4.com/c/202927/383177/
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Organic Life Guide  https://jvz8.com/c/202927/366872/
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Video Campaignor      https://jvz4.com/c/202927/387058/
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VideoEnginePro     https://jvz2.com/c/202927/372916
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VideoRobot Enterprise   https://jvz8.com/c/202927/291061
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WebCop  https://jvz4.com/c/202927/378683/
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WordPress Mastery   https://jvz1.com/c/202927/386249/
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