How Australia’s Keyman Investment offering Advisory Needs

Keyman Investment  is a Australia registered company formed with a motive to make the world earn easy money . Keyman Investment draws attention to safety of its clients investments. It means that analysts and experts in economics and finance do a huge work of monitoring, analysis and forecasting the situation on the markets. Their recommendations allow to respond quickly to processes occurring on the exchange, so there can be no price fluctuations which cause negative consequences.

They bring together a wide range of insights, expertise and innovations to advance the interests of their clients around the world. They offer a big number of 10% who promote their business  and build long-term and trusted relationships with their clients – wherever they are and wherever they invest.

They have professional highly trained and experienced team in their field of expertise enabling to provide the quality services demanded. They are seeking  to create value for their clients by constantly looking for innovative solutions throughout the investment process.

What started out as a market for professionals is now attracting traders from all over the world, and of all experience levels and all because of online trading and investment. They are also to providing a  comprehensive resource for clients new to the market or with limited experience trading Cryptocurrency investment, or interested in Forex, gold trade or stock market.

Bronze Plan

2% Daily for 6 Days
  • Minimum – $100
  • Maximum – $15,999
  • Principal Included
  • Instant Payout

Silver Plan

2.5% Daily for 6 Days
  • Minimum – $16,000
  • Maximum – $24,999
  • Principal Included
  • Instant Payout

Gold Plan

3% Daily for 6 Days
  • Minimum – $25,000
  • Maximum – $49,999
  • Principal Included
  • Instant Payout

Diamond Plan

4% Daily for 6 Days
  • Minimum – $50,000
  • Maximum – No Limit
  • Principal Included
  • Instant Payout

Through their unique combination of expertise, research and global reach, we work tirelessly to anticipate and advance what’s next—applying collective insights to help keep our clients at the forefront of change. They bring together a wide range of insights, expertise and innovations to advance the interests of our clients around the world.

Source: Keyman Investment Pty

The 5 Biggest IT Mistakes Companies Make And How To Avoid Them

Young woman working at home

A new study released by research firm Gartner shows that employees are nearly two times more likely to pretend to be working when their employers use tracking systems to monitor their output. Gartner surveyed more than 2,400 professionals in January 2021.

Across the world, IT professionals are in charge of an increasing number of servers and data coming in from disparate sources, and they’re using way too many monitoring tools to make sense of it all. The Reducing Complexity in IT Infrastructure Monitoring: A Study of Global Organizations report by the Ponemon Institute sheds light on the challenges of troubleshooting and monitoring cloud and on-premises environments.

  • 24% said the handling of scale and complexity of IT infrastructure has improved
  • 29% said the ability to easily deploy and maintain server monitoring technologies has improved

The survey also found that while a significant percentage of IT practitioners are in charge of monitoring over 50 servers, only 33% felt that they could ensure performance and system availability with their current toolset. So how can IT effectively manage increasingly complex, hybrid environments, and what are the major missteps IT organizations can correct to build a more efficient approach to infrastructure monitoring and troubleshooting?

Here are some of the biggest IT mistakes companies of all sizes make — and how to avoid them.

Problem #1: Too Many Tools

Seventy percent of IT professionals in the survey said that using data to determine root cause slows them down — ingesting and normalizing data of differing formats and types is tedious and unmanageable, and it’s difficult to make real-time decisions. This is often because companies use too many monitoring tools for single layers of their IT stack, such as networks or applications, which creates silos and inefficiencies. When data lives inside one tool but can’t access or communicate with data confined to other tools, IT practitioners lose context on what’s happening in their environment because they’re seeing only a part of the picture.

The Solution: The solution to too many tools and disparate data is a single, scalable monitoring tool that provides end-to-end operational visibility into hybrid environments.

Problem #2: IT and Business Friction

As digital business infrastructure increases in complexity, IT teams feel more pressure than ever to reduce business-impacting incidents. When IT systems fail, the ramifications go beyond the immediate financial loss of downtime — a business could lose customers and jeopardize its reputation, a harsh reality that keeps IT teams up day and night. According to Ponemon’s research, 61 percent of IT professionals say that lack of system availability and poor performance creates friction between IT and lines of business.

The Solution

In addition to a solution that allows IT to find the root cause to identify service interruptions, IT and business need to work together to design business and technical requirements in tandem.

Problem #3: No Way to Easily Identify Root Cause

Across the globe, IT professionals spend their days identifying and fixing server environment problems. Indeed, the Ponemon survey found that the top two challenges of troubleshooting, monitoring and cloud migration are:

  • Lack of insights to quickly pinpoint issues and identify the root cause
  • Complexity and diversity of IT systems and technology

When IT can’t find and fix issues quickly, it has a direct effect on the business.

The Solution: For IT to quickly fix problems, they need a monitoring tool that can surface an issue’s root cause with an alert about where and why something is wrong. Issue resolution time can be cut in half with a monitoring solution that correlates metrics and logs, and provides visualizations of alerts, trends and logs in one place. Making sure your monitoring tool can enable those types of actions and resolution planning is critical for success.

Problem #4: The Wrong Skills to Manage Application Complexity

When Ponemon asked IT professionals about the biggest risks to their ability to troubleshoot, monitor and migrate to the cloud:

  • 55%  said the increasing complexity of applications running on infrastructure
  • 44%  said a lack of skills and expertise to deal with application complexity

As infrastructure grows and evolves, it becomes increasingly difficult for IT teams to successfully manage, monitor and troubleshoot systems. Couple that with an IT skills gap that makes it difficult for organizations to attract and retain qualified talent, and it becomes clear why IT teams feel nonstop pressure.

The Solution: To effectively troubleshoot, monitor and migrate to the cloud, you need a solid plan that takes future growth into account is necessary for smooth IT operations. Business and IT need to work together to create an IT environment roadmap, followed by a talent strategy that aligns to that plan. Be sure to:

  • Identify skills gaps and adjust hiring
  • Identify and train qualified employees for advancement
  • Include succession planning for inevitable changes

Problem #5: Lack of Visibility Throughout Cloud Migration

Sixty-eight percent of IT practitioners said that ensuring application performance and availability throughout cloud migration caused the most stress. Over half said both cost and the inability to monitor and troubleshoot applications were their biggest pain points.

As infrastructure increases in complexity, the core responsibilities of IT to monitor and measure remain the same. So how can IT achieve infrastructure visibility and workload insights when performance data spans diverse environments?

The Solution: It’s critical to monitor performance across hybrid architectures with a monitoring solution that collects and correlates data from every location. Full visibility is needed throughout the migration process, so choose an end-to-end monitoring tool that allows you to establish a pre-migration baseline, mid-migration insights and post-migration success.

Before cloud migration, measure the baseline user experience and performance, and define acceptable post-migration levels. To accurately validate a migration’s success, use the same monitoring tool throughout the migration process. A unified tool can analyze centralized data and provide better insights from dashboards and reports.

For more of the biggest IT mistakes and solutions and examples of companies that have solved the problem check out: 8 Biggest Mistakes IT Practitioners Make and How to Avoid Them.

Splunk Inc. turns data into doing with the Data-to-Everything Platform. Splunk technology is designed to investigate, monitor, analyze and act on data at any scale.

Source: The 5 Biggest IT Mistakes Companies Make And How To Avoid Them

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More Contents:

Employees Are More Likely To Pretend They’re Working When Employers Track Their Productivity: Here’s Why

Shocked african business man feel frustrated looking at laptop screen

Big Brother-like attempts by employers to track the productivity of remote workers seems to be backfiring.

A new study released by research firm Gartner shows that employees are nearly two times more likely to pretend to be working when their employers use tracking systems to monitor their output. Gartner surveyed more than 2,400 professionals in January 2021.

“Our role as managers is to create an environment where people can do their best work. It’s really hard to do your best work if you feel like you are not trusted,” says Carol Cochran, vice president of people and culture at remote career site FlexJobs. “If I feel like someone doesn’t trust me enough to feel like I’m doing my work without monitoring through software, how do I trust them back? How do I build that physical safety?”

This past year, there’s been an uptick in reports of companies using monitoring software to keep tabs on their newly remote workforces, turning to technology to track their keystrokes and search histories, as well as tools to take periodic screenshots of their computers.

Reid Blackman, founder and CEO of corporate ethics consulting firm Virtue Consultants, said he’s not surprised employees are falsifying their work. “Obviously people are going to game the system … especially if they think the system is unfair,” he says.

Though he says it’s not unreasonable for managers to have concerns about  their workers’ productivity, he suggests they think critically about why they want to use such software and what they stand to accomplish before deploying any systems. Blackman also recommends discussing the move with employees beforehand so they can ask questions and understand the reasoning behind it.

Alexia Cambon, a research director at Gartner, says employers’ initial instincts to track their employees may have been well-intentioned, especially in the early days of the pandemic, when there was a need to recreate in-office strategies at home. However, many companies did not take human behavior into consideration, she says.

“If you know that, as humans, we will struggle to disconnect from a remote world …. then you really need to create strategies to incentivize people to disconnect and not stay on longer hours,” Cambon says.

Gartner also found that adapting office-centric practices for hybrid work environments, such as creating an abundance of meetings, has led to virtual fatigue. Employees who now spend more time in meetings are 1.24 times more likely to feel emotionally drained from their work, the study found.

Cambon cautions that when employees experience high levels of fatigue, their performance can decrease by up to 33% and feelings of inclusion can decrease by up to 44%. Ultimately, these workers are up to 54% less likely to remain with their employers, she says.

Contrary to prevailing advice, Cochran advises companies to reconsider asking their employees to turn on their cameras for video meetings, as doing so can make them more exhausting. As a compromise, she suggests that everyone turn on their cameras for the first couple of minutes to exchange pleasantries with coworkers, but turn them off when it’s time to work.

“We shouldn’t do things just because it seems right or seems like the best practice,” she says. “We really need to be intentional in how we are managing these workforces, whether they are remote, hybrid or in person.”

I’m the Careers reporter at Forbes. Previously, I covered the world’s richest people as a member of the wealth team. Before joining Forbes, I reported for the Hartford Courant and the New Haven Register, covering breaking and local news. A Connecticut native, I studied journalism at Penn State University. Follow me on Twitter @KristinStoller.

Kristin Stoller

 

By:

 

Source: Employees Are More Likely To Pretend They’re Working When Employers Track Their Productivity: Here’s Why

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► Find us at https://www.bernieportal.com/hr-party… Remote work can be tough on teams. In this episode, Ryan covers the struggles HR professionals face with engagement, the productivity tracking platforms that can solve these issues, and how to communicate updates to your team. BerniePortal: The all-in-one HRIS that makes building a business & managing its people easy. http://bit.ly/2NEQ5Qb
What is an HRIS? https://bit.ly/what-is-an-hris Stay up to date with the latest HR news and benefits administration by subscribing to the BerniePortal Blog https://blog.bernieportal.com/ Related Blog: Five Great Productivity Tools for Remote Workers https://blog.bernieportal.com/five-gr… Related Blog: Tips for Tracking Remote Work Employee Engagement https://blog.bernieportal.com/track-e… One Sheet Guide: Technology for Remote Workers by BerniePortal & BernieU https://cdn2.hubspot.net/hubfs/131307… Related Episode: Overtime Pay: Exempt vs. Non-Exempt https://www.bernieportal.com/hr-party…
Referenced Article: Gallup: Reviewing Remote Work in the U.S. https://news.gallup.com/poll/311375/r… For more check out the HR Party of One Tips for Working Remotely Playlist on YouTube https://www.youtube.com/playlist?list… Hubstaff, the employee tracking software we use. https://hubstaff.com/ BernieU: Your free one-stop-shop for compelling, convenient, and comprehensive HR training and courses that will keep you up-to-date on all things human resources. Approved for SHRM & HRCI recertification credit hours. Enroll today! https://university.bernieportal.com/
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This Remote Patient Monitoring Startup Just Landed A $70 Million Series C

Health Recovery Solutions in action

hen Covid-19 cases began to soar around Ann Arbor in April, the University of Michigan Hospital reached 100% capacity. Like most hospitals, University of Michigan Hospital was not ready for the pandemic surge, but they did have a leg up.

That same month they’d coincidentally implemented Health Recovery Solutions’ remote patient monitoring, a patented technology system that records patient vitals via Bluetooth and connects them with their clinicians through video or instant messaging. This enabled the resource-strapped hospital to care for over 400 patients remotely throughout 2020.

Today, HRS announced it closed a $70 million series C led by LLR Partners with participation from existing investor Edison Partners, bringing the Hoboken, New Jersey-based startup’s total funding to $86 million. The news comes on the heels of a year of massive growth, which saw their head count balloon 258% to 155 employees and revenue grow by 188% to $23.5 million.

“People are choosing the proven remote-monitoring solution right now,” says Jarrett Bauer, HRS’ Forbes 30 Under 30 cofounder and CEO. “That’s one of the reasons why we’re doing so well—people are looking for the company that’s best.”

Bauer, now 34, was inspired to start by HRS by his grandma. Battling a heart condition, Bauer’s grandma was admitted to the hospital three times, resulting in over $14,000 of medical bills. While pursuing his M.B.A. at Johns Hopkins in 2012, Bauer began constructing an at-home hospital alternative that would eventually become HRS. “We didn’t know where to start,” Bauer told Forbes in 2019 when the company raised its $10 million series B. “We just knew it was a problem, and the best companies solve problems.”

With Covid-19, telehealth doctor appointments have become just doctor appointments, increasing 154% from March to October of 2020, according to the Centers for Disease Control. Rather than cut into HRS’ margins, the telehealth boom has helped HRS soar. The healthcare company has deals with over 220 U.S. healthcare systems—74 of which signed on as clients of HRS during the pandemic—with over 20,000 nurses checking HRS logs every day.

“We consider Health Recovery Solutions the Cadillac model,” says Brandy Knudson, Michigan Medicine’s Telehealth Project Manager. “It fills a huge gap for us because we want to reduce readmissions and reduce unnecessary trips to the hospital.”

The company makes money by billing clinical institutions on subscription to integrate their solutions in treatment, coming at no additional cost to patients. HRS recognizes the varying levels of sickness and technological ability of patients, so the company’s products range from a pulse oximeter for the sickest, while near-recovered patients can manually enter symptoms on HRS’ smartphone app.

All of this patient data is stored in a cloud for clinicians, making it easier to recognize prognosis patterns and health trends. By implementing HRS, major healthcare systems like Penn Medicine have reduced 30-day readmission by over 50% for all heart failure patients, while FirstHealth of the Carolinas says the technology has saved patients more than $1.9 million since its implementation in 2016.

“Patients are looking to stay in their homes longer, get care in their homes longer, and there’s an increasing prevalence of chronic conditions,” says Sasank Aleti, a partner at Philadelphia-based private equity firm LLR Partners. “HRS met our criteria of taking costs out of the system, driving better outcomes and a better patient experience.”

For Bauer, the future of HRS lies in universalizing hospital-from-home treatment. With the $70 million round, the company plans to more than double head count in 2021 to 250 employees with the goal of being able to treat over a million patients by adding new healthcare providers and upping their disease module count (they currently treat 90 diseases). “Why aren’t we like Google? Why aren’t we like Apple?” asks Bauer. “We’re playing to win—to be that.”

I’m the Under 30 Editorial Community Lead at Forbes. Previously, I directed marketing at a mobile app startup. I’ve also worked at The New York Times and New York Observer. I attended the University of Pennsylvania where I studied English and creative writing. Follow me on Instagram and Twitter at @iamsternlicht.

Source: This Remote Patient Monitoring Startup Just Landed A $70 Million Series C

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The coronavirus pandemic has overwhelmed hospitals, physicians and the medical community. That’s pushed telemedicine into the hands of providers and patients as the first response for primary care. Telemedicine isn’t new to the medical community, however it hasn’t been embraced due to insurance coverage, mindset and stigma. Here’s how it works and what it means for the future of health care. » Subscribe to CNBC: https://cnb.cx/SubscribeCNBC » Subscribe to CNBC TV: https://cnb.cx/SubscribeCNBCtelevision » Subscribe to CNBC Classic: https://cnb.cx/SubscribeCNBCclassic
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[…] Other companies to recently launch new telehealth capabilities include Hims & Hers, a telehealth startup that went public in a $1 […]
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insider.fitt.co – January 26
[…]   Telehealth startup hims went public in a SPAC deal with Oaktree Acquisition Corp […]
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Female-Founded Telehealth Startup Calibrate Announces $22.5 Million Series A on 27 January
http://www.iweller.com – January 26
Calibrate, a female-founded telehealth startup that aims to provide patients with a metabolic reset, announced Tuesday that it has raised a $22 […] Calibrate When Calibrate—the female-founded telehealth startup trying to disrupt the $70 billion weight loss industry—came out of stealth mode in June, it wa […]
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Female-Founded Telehealth Startup Calibrate Announces $22.5 Million Series A
http://www.forbes.com – January 26
When Calibrate—the female-founded telehealth startup trying to disrupt the $70 billion weight loss industry—came out of stealth mode in June, it wa […]
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Bene Studio –
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[…] Schedule: Startup pitches and the Telehealth Startup Award 8:00–9:00 (PDT) / 16:00–17:00 (GMT+1) 4 growth stage health startups pitch their product an […] Who will win the Telehealth Startup Award in September? Panel Discussion: How does Telehealth improve Health Systems? 9:30–10:30 (PDT […]
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LIST OF FASTEST GROWING FRANCHISES IN AMERICA :: Stock market news, Stock spinoff and breaking finance news.
[…] GoTelecare Franchise fee: $100,000 (in liquid assets) Initial investment: $60,000 GoTelecare is a telehealth startup that is currently building a franchise business model […]
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[…] Telehealth startup Hims & Hers Health Inc […]
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[…] Health benefits platform Accolade is buying telehealth startup 2nd […]
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Hims, The Telehealth Start-up, Saw Its Shares Slide In Its Business Debut – And That’s Great For Its CEO – TechCrunch
Hims & Hers, a San Francisco-based telehealth startup that sells sexual wellness and other health products and services to millennials, began tradin […]
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Telehealth startup Hims fell in its public trading debut – and that’s fine with its CEO Source : techcrunch.com<br />…
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Forging Trust In AI, Sustaining The Virtual Care Boom And Other CES Takeaways – Food, Drugs, Healthcare, Life Sciences – United States
http://www.mondaq.com – January 21
[…] of specialization within telehealth that people will really gravitate towards,” Varsha Rao, CEO of telehealth startup Nurx, said Tuesday […]
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medium.com – January 19
[…] <source> Calibrate, a New York, NY-based female-founded telehealth startup that aims to provide patients with a metabolic reset, raised $22 […]
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http://www.geekwire.com – January 19
[…] -based telehealth startup, has raised another $8 million as part of an expanded Series B round […]
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TeeRoy’s 2 Cents Rumor Report 1/19/21 | 100.9 The Beat
wjbt.iheart.com – January 19
[…] already has stake in Wingstop and Checkers recently put a million dollars into the Florida-based Telehealth startup Jetdoc […]
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[…] of specialization within telehealth that people will really gravitate towards,” Varsha Rao, CEO of telehealth startup Nurx, said Tuesday […]
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hiphopdx.com – January 17
[…] According to Forbes, the 44-year-old Ross is making a seven-figure investment into Florida-based telehealth startup Jetdoc […]

How Your Credit Card Information Is Stolen and What to Do About It

Your credit card information can be stolen right under your nose without the actual card leaving your possession. Unfortunately, most victims of this type of credit card theft don’t what’s happening until after their credit card account information has already been used. Often, fraudulent credit card charges are the first sign that credit card information has been stolen. Fortunately, there are a few steps you can take to clear your name and get your credit card accounts under control.

How Thieves Steal Credit Card Information

In many instances, thieves don’t steal your credit card information directly from you. Instead, they get it somewhere else in the credit card processing chain.

Hacking Into Other Businesses

Thieves can steal your information by breaching a company where you’ve used your credit card or a company that handles some aspect of credit card processing. Since data breaches target entire organizations, sometimes millions of consumers have their credit card information stolen, as was the case in the Equifax data breach of 2017.2

Skimming

A credit card skimmer is a small device that captures your credit card information in another otherwise legitimate transaction. Thieves secretly place credit card skimmers over the credit card swipe at gas stations and ATMs and retrieve the information captured.

Installing Malware or Viruses

Hackers can design software that’s downloaded in email attachments or other software and sits on your computer, tablet, or smartphone undetected. In one instance, hackers take advantage of public Wi-Fi to trick people into installing malware disguised as a software update. The software monitors your keystrokes or takes screenshots of your page and sends the activity to the thief

Phishing Scams

Thieves set up traps to trick consumers into giving up credit card information. They do this by phone, by email, through fake websites, and sometimes even via text message. In one scam, for example, you may verify some personal information in a call that you think is from your credit card issuer’s fraud department, but it’s really from a scammer. It’s important that you only give out your credit card and other personal information only in transactions you can be sure are safe.6

Dumpster Diving

Throwing away documents or receipts that have your full credit card number printed puts you at risk of theft. Always shred these documents before tossing them in the trash. Unfortunately, you can’t control how businesses dispose of their records. If they fail to shred records that contain credit card information, the information is at risk of being stolen.

What Thieves Do With Your Credit Card Information

If a thief gets access to your credit card information, they can profit from it in a few different ways. All of them can make life more difficult for you. Thieves can use your credit card information to buy things over the internet. It’s much easier for them to do this if they also have your billing zip code and the security code from the back of your credit card.

Thieves may also sell your credit card information on the dark web—and the more information they have, the more it’s worth. For example, it may be sold for a higher price if the thief also has your name, address, date of birth, mother’s maiden name, and three-digit security code from your credit card.8

Thieves can also make legitimate-looking credit cards by programming your credit card information on a gift card or prepaid credit card. When the card is swiped, the transaction processes just like it would if you swiped your actual credit card.9

How to Know If Your Credit Card Information Has Been Stolen

This kind of credit card theft can go undetected for several months. It’s not like a physical credit card that you notice is missing. You likely won’t know until you notice unauthorized charges on your credit card account.

Don’t count on your bank to catch instances of credit card theft. Your credit card issuer may call you or freeze your account if they notice purchases outside your normal spending habits, but don’t take for granted that your bank will always notify you of potential fraud.

Monitor your credit card often and immediately report fraudulent purchases, regardless of the amount. It’s not enough to read through your transactions once a month when your credit card statement comes. Once a week is better, and daily or every other day will let you spot fraudulent purchases before the thief can do too much damage to your account. Some credit cards can send real-time transaction notifications to your smartphone.

Also pay attention to news regarding hacks and data breaches. News reports will often include the name of the store affected and the date or date range the data beach occurred. If you shopped during that time period, there’s a chance your credit card information was stolen.

What to Do If Your Credit Card Information is Stolen

It’s easy to know when your actual credit card has been stolen because your credit card is actually gone. It’s not as easy to know when your credit card information has been stolen. Often, you only notice signs that hint your credit card information has been stolen, like unauthorized purchases on your credit card.1

If you think you’ve been a victim of identity theft of any kind, including having your credit card information stolen, then you can visit IdentityTheft.gov. The website, which was created by the Federal Trade Commission, will walk you through the steps you need to take to report it and recover.

Review your recent credit card transactions to see if there are any you didn’t make. Note the fraudulent charges you found. Even if you didn’t find any fraudulent charges, call your credit card issuer and let them know you think your credit card information has been stolen. Let your card issuer know of any transactions on your account that you didn’t authorize.

You have protection under the Fair Credit Billing Act and the Electronic Fund Transfer Act if your credit information is stolen. You’re not liable for any unauthorized charges so long as you report the loss before your credit card is used. You must report the transactions to your credit card issuer so they can investigate and remove them from your account.

The credit card issuer will cancel your old credit card account, remove the fraudulent transactions from your account, and send a new credit card and a new credit card number. Continue monitoring the transactions on your new credit card. Also shred any documents with your credit card information on them. As soon as you start using your credit card, the details are at risk of being stolen.

Keeping Your Credit Card Information Safe

If you use your credit card at all, anywhere, your information is at risk. Still, there are a number of things you can do to keep your credit card information safe. That includes using strong passwords, being cautious about where you use your credit card, always using secure websites, and avoiding storing your credit card details in your web browser.13

By LaToya Irby

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New Covid Strain: How Many Variants of Coronavirus Are There

The emergence of variants is linked to ongoing surges since infections give viruses the chance to mutate and spread.

Many variants of the coronavirus are circulating around the world, but scientists are primarily concerned about three. How many variants of the coronavirus are there?

There are many circulating around the world, but health experts are primarily concerned with the emergence of three. As a virus infects people, it can mutate as it makes copies of itself. Some mutations can be harmful to a virus, causing it to die out. Others can offer an advantage and help it spread.

“Not every mutation is created equal,” said Dr. Mary Petrone, who studies infectious diseases at Yale University. “The virus is going to get lucky now and again.”Monitoring variants is important because of the possibility that they could make vaccines and treatments less effective, or change the way they infect people.

A mutation early in the pandemic fueled the spread of the virus around the world, but there had been no notable changes since — until recently, said Ohio State University biologist Daniel Jones.

One of the three main variants experts are watching was discovered in the United Kingdom late last year and has been detected in dozens of countries since. Health officials initially said it didn’t seem to cause worse disease, but some newer information suggests it might — that remains unknown at the moment. It does appear to spread more easily, which could lead to more hospitalisations and deaths.

The variant might become dominant in the US by March, according to the Centers for Disease Control and Prevention. Other variants first detected in South Africa and in Brazil also appear more contagious, experts say.

Data so far suggests current vaccines should still protect against these variants, though there’s some concern their effectiveness may be slightly diminished. There is some evidence that some antibody treatments may be less effective against certain variants.

There are ways to adjust vaccines and treatments to maintain their effectiveness, said Dr. Anthony Fauci, the top US infectious disease expert.The emergence of variants is linked to ongoing surges since infections give viruses the chance to mutate and spread. It’s another reason experts stress the importance of mask wearing and social distancing.

“The fewer humans carrying the virus, the fewer opportunities it has to mutate,” Jones said.The announcement that the coronavirus strain sweeping Britain could be more deadly as well as more transmissible has raised fresh concerns about the variant that has spread to dozens of countries.

Initially British experts said that their evidence suggested the new strain circulating in the UK — one of several to have emerged internationally in recent months — was between 50 per cent and 70 per cent more transmissible.On Friday, however, the government said the new variant could also be 30-40 percent more deadly, although it stressed the assessment relied on sparse data.

What has changed?

In mid-January, two separate studies by London School of Hygiene and Tropical Medicine and Imperial College London were presented to Britain’s New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG).They linked data from people who tested positive for the virus in the community — rather than in hospital — with death data and found a roughly 30 percent increase in the risk of death associated with the new strain.

The groups used slightly different methods, but both matched people with the new variant to those with the older variants, taking into account other variables like age and location and controlling for hospitals being under pressure.Other studies by Exeter University and Public Health England also found higher deaths and both came up with even higher figures.

Based on these analyses, NERVTAG said there was “a realistic possibility” that infection with the new variant is associated with an increased risk of death compared with previously circulating variants.The increase in transmissibility associated to the variant was already causing alarm, because the more people the virus infects the more people will suffer serious illness and the risk of death.

“Unfortunately, it looks as if this virus might be both” more infectious and potentially more deadly, John Edmunds, a professor in LSHTM’s Centre for the Mathematical Modelling of Infectious Diseases, told a press briefing Monday”So it’s really a serious turn for the worse unfortunately,” he said.

How reliable are the findings?

Researchers said there were still uncertainties in the data and said the picture would become clearer in the next few weeks.Edmunds said the findings were “statistically significant”.But he said while the studies used information from those tested in the community, most people who die of Covid-19 go straight to hospital and are tested there.

Researchers do not yet have that hospital information.NERVTAG said this lag in data could be why the studies did not find evidence of an increase in hospitalisations of people with the new variant, which seems at odds with the findings of increased severity of disease.

It also said the mortality data used in the research only covers eight percent of the total deaths during the study period and said the results “may therefore not be representative of the total population”.

Why more deadly?

Researchers think it could be the same set of mutations that has made it more infectious — although all stress more study is needed.One mutation in particular increases the virus’ ability to latch on more strongly to human cells and NERVTAG head Peter Horby, an emerging infectious disease professor at Oxford University, said evidence suggests this means it could make it easier to become infected.

“If it’s then able to spread between cells much quicker within the lungs, that may increase the rate of disease and the rate of inflammation, which may then progress quicker than your body can respond to, so it could explain both characteristics of the virus,” he said.Bjorn Meyer, virologist at France’s Institut Pasteur, told AFP that the issue could be viral load.

“The virus might not have evolved to be more deadly as such, but it might have evolved to grow more or better, which could cause more damage in a patient overall,” he said.

Does this affect treatments?

Horby, who also leads the Recovery trial — which identified the steroid dexamethasone as effective for severely ill hospital patients — said there was “no evidence” that treatments would work less well. Anti inflammatories such as dexamethasone “should work equally as well because it’s not related to the virus, it is related to the host response”, he said.

Horby said overall improvements in therapies and treatments — including things like better strategies for hospital respiratory support — have brought down case fatality rates since the first wave and could even “offset any difference with this new variant”.

As for the vaccines, a preliminary study this month from Britain and the Netherlands found the variant would not be able to evade the protective effect of current vaccines. Pfizer/BioNTech and Moderna have also released early research suggesting their vaccines would still be effective against the strain.

Don’t viruses weaken as they spread?

Scientists have sought to challenge the belief that the virus will become get less virulent as it evolves to become more infectious. The virus that causes Covid-19 is already “very good at its job of getting transmitted” said Emma Hocroft, an epidemiologist at the University of Bern.

“So I don’t think that we can make this assumption that it wants to be less severe. I don’t want to downplay that it is severe for many people, but for the majority of people, it’s not severe,” she told AFP. She said the ability to transmit before it kills was “a really low bar”, citing diseases like measles and HIV that have remained as dangerous.

Graham Medley, a professor of Infectious Disease Modelling at the LSHTM, told the Monday press briefing that despite uncertainties in the new studies on the new variant in the UK, they should dispel the idea that it would become less virulent. “It’s certainly not the case that this is a more benign virus,” he said.

By: https://www.khaleejtimes.com/

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MedCram – Medical Lectures Explained CLEARLY

Professor Shane Crotty, Ph.D. explains recent coronavirus mutations and how they might impact COVID 19 vaccines and transmission. COVID-19 research of Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science: https://science.sciencemag.org/conten… Prof. Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Prof. Crotty also has an academic appointment with the University of California San Diago. See his full bio here: https://www.lji.org/labs/crotty/#over… Prof. Crotty on Twitter: https://twitter.com/profshanecrotty Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com TOPICS DISCUSSED IN THIS VIDEO INCLUDE: 0:00 Intro 0:08 SARS-CoV-2 / COVID 19 mutations (UK variant etc.) and implications for COVID-19 vaccines 10:58 How to test if coronavirus variants can escape immunity 12:28 How have mutations made this virus more transmissible? 17:44 Could mutations make vaccines less than 50% effective? 24:15 Possible changes to vaccine schedules (one dose, half dose)? 35:34 Could alternate COVID-19 vaccine schedule make mutations more likely? 38:29 What is next for Prof. Crotty and his team? (This video was recorded on January 5, 2021) PREVIOUS DISCUSSION WITH PROF. CROTTY (Dec 16, 2020): https://youtu.be/eK0C5tFHze8 REFERENCES: Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn (Science) | https://www.sciencemag.org/news/2021/… Vaccine Tracker (Bloomberg) | https://www.bloomberg.com/graphics/co… FDA Statement on Following the Auth. Dosing Schedules for COVID-19 Vaccines | https://www.fda.gov/news-events/press… S-variant SARS-CoV-2 is assoc. with sig. higher viral loads in samples tested by ThermoFisher TaqPath RT-QPCR (MedRxiv) | https://www.medrxiv.org/content/10.11… Human Leukocyte Antigen (HLA) System | https://www.merckmanuals.com/professi… UK reports new variant, termed VUI 202012/01 (GISAID) https://www.gisaid.org/references/gis… Covid-19 in South Africa: Scientists seek to understand new variant (BBC) | https://www.bbc.com/news/world-africa… Mutation Allows Coronavirus to Infect More Cells. Scientists Urge Caution (NY Times) | https://www.nytimes.com/2020/06/12/sc… The UK is delaying second vaccine shots and it’s proving controversial (CNBC) https://www.cnbc.com/2021/01/05/the-u… The receptor binding domain of the SARS-CoV-2 (News Medical Life Sciences) | https://www.news-medical.net/news/202… NY Times article highlighting Prof. Shane Crotty’s research: https://www.nytimes.com/2020/11/17/he… THE MEDCRAM WEBSITE: Visit us for videos on over 60 medical topics and CME / CEs for medical professionals: https://www.medcram.com SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL: https://www.youtube.com/user/MEDCRAMv… Get notified of new videos by hitting the bell icon! PREVIOUS / RECENT MEDCRAM COVID-19 INTERVIEWS: Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) with Professor Roger Seheult, MD https://youtu.be/ha2mLz-Xdpg At Home COVID 19 Antigen Testing and Vaccine Update with Professor Michael Mina, MD https://youtu.be/CjphzlV5DYo All coronavirus updates are at MedCram.com ad-free (including more videos on RNA vaccines, BioNTech vaccine, vaccine side effects, AstraZeneca Oxford coronavirus vaccine, new strain of coronavirus, and more): https://www.medcram.com/courses/coron… We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website and CME for clinicians. MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS: MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested. MEDIA CONTACT: Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-c… Video Produced by Kyle Allred FOLLOW US ON SOCIAL MEDIA: https://www.facebook.com/MedCramhttps://twitter.com/MedCramVideoshttps://www.instagram.com/medcram DISCLAIMER: MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #COVID19#SARSCoV2#Coronavaccine

7 Facts That Will Make You Rethink Application Performance Monitoring – Mike Sargent

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Digital transformation is changing the way companies do business, so it should come as no surprise that the applications that deliver business services are under pressure to keep up. Application teams are embracing a full mix of technologies– from mobile first to cloud-native architectures, to enable more agility, innovation, and end-user focus than ever before. Yet with more technology comes more complexity, more need for visibility, more components to monitor– and also more data. As digital transformation sweeps the world, the following seven data points can help inform your application performance monitoring (APM) strategy ………..

Read more: https://www.forbes.com/sites/riverbed/2018/11/06/7-facts-that-will-make-you-rethink-application-performance-monitoring/#6565ec746e84

 

 

 

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