Advertisements

More Blood Pressure Medication Recalls Due To Cancer Concerns

You may want an MBA. But you want to avoid NMBA.

NMBA stands for N-Methylnitrosobutyric acid, something that you don’t want in your blood pressure medications. But alas, this probable carcinogen continues to appear in various medications at higher than acceptable levels.

The latest news is that Torrent Pharmaceuticals Limited is further expanding its recall of Losartan Potassium Tablets USP and Losartan Potassium/hydrochlorothiazide tablets, USP, according to the U.S. Food and Drug Administration (FDA). The FDA announcement includes five more lots of these medications. The additional lots add to the lots of blood pressure medications that have been recalled in the past 14 months or so.

In 2018 and 2019, it seems like news about potential cancer-causing contaminants in medications has become as repetitive as the lyrics “My Name Is” in Eminem’s song “My Name Is.” I’ve written about such news for blood pressure medications in November of last year, January of this year, and again March of this year. Then, just last week I covered impurities found in a common heartburn medication, ranitidine. Then, on Thursday, I added an update that Novartis was halting its distribution of ranitidine, the generic form of Zantac, until further testing could be done.

Today In: Innovation

As they say when you soil your pants, one time may be an accident but more than three times is a trend. It is time to take a closer look at how drugs are being manufactured, stored, and distributed and how such processes are being monitored. As I have mentioned before, making medications is not the same as making handbags. You don’t, at least you shouldn’t, eat your handbags. While a poorly-made handbag could lead to social embarrassment, a poorly-made medication can have much greater and even life-threatening implications.

The FDA is the main agency to protect you against fraudulent and contaminated medications. But the FDA currently may not have the funding and the resources to carefully check everything that every drug manufacturer and distributor is doing, especially when some of these operations are rapidly changing or occurring overseas.

For now, if you are taking blood pressure medications, or any medications for that matter, pay attention to FDA warnings and recall news. The FDA maintains a searchable listing of active product warnings and recalls. As a precautionary measure, you may want to search for a medication before starting it. You can also check with your pharmacist to make sure that your medication is not on a recall or warning list. Of course, if you do find that your medication has a warning or is being recalled, don’t just stop taking it. That can be like trying to return a parachute while you are using it. Check with your doctor first to determine your course of action.

Follow me on Twitter or LinkedIn. Check out my website.

I am a writer, journalist, professor, systems modeler, computational and digital health expert, avocado-eater, and entrepreneur, not always in that order. Currently, I am a Professor of Health Policy and Management at the City University of New York (CUNY), Executive Director of PHICOR (@PHICORteam), and Associate Professor at the Johns Hopkins Carey Business School. My previous positions include serving as Executive Director of the Global Obesity Prevention Center (GOPC) at Johns Hopkins University, Associate Professor of International Health at the Johns Hopkins Bloomberg School of Public Health, Associate Professor of Medicine and Biomedical Informatics at the University of Pittsburgh, and Senior Manager at Quintiles Transnational, working in biotechnology equity research at Montgomery Securities, and co-founding a biotechnology/bioinformatics company. My work involves developing computational approaches, models, and tools to help health and healthcare decision makers in all continents (except for Antarctica) and has been supported by a wide variety of sponsors such as the Bill and Melinda Gates Foundation, the NIH, AHRQ, CDC, UNICEF, USAID and the Global Fund. I have authored over 200 scientific publications and three books. Follow me on Twitter (@bruce_y_lee) but don’t ask me if I know martial arts.

Source: More Blood Pressure Medication Recalls Due To Cancer Concerns

121K subscribers
Dr. Luke Laffin, staff cardiologist in Preventive Cardiology and Clinical Specialist in Hypertension at Cleveland Clinic answers questions that patients often ask about taking high blood pressure medicines: types of medications, side effects, when to call the doctor, role of self-blood pressure monitoring (including how often), the best time to take blood pressure medications, and if there is a chance that patients can come off medications. He ends the program with three important points for patients with high blood pressure.

Advertisements

Promising Blood Test Could Help to Predict Breast Cancer Recurrence

4.jpeg

Doctors have gotten much better at detecting and treating breast cancer early. Drug and chemotherapy regimens to control tumors have gotten so effective, in fact, that in some cases, surgery is no longer necessary. In up to 30% of cases of early-stage breast cancer treated before surgery, doctors can’t find evidence of cancer cells in postoperative biopsies. The problem, however, is that there is currently no reliable way to tell which cancers have been pushed into remission and which ones have not.

That’s where an easy identifier, like a blood test, could transform the way early stage breast cancer is treated. In a paper published in Science Translational Medicine, researchers led by a team at the Translational Genomics Institute (TGen), an Arizona-based nonprofit, report encouraging results on just such a liquid biopsy. Its test, called Targeted Digital Sequencing (or TARDIS), was up to 100 times more sensitive than other similar liquid-biopsy tests in picking up DNA shed by breast cancer cells into the blood.

Currently available ways of tracking breast cancer cells in the blood are most useful in people with advanced cancer. In those conditions, cancer cells litter the blood with fragments of their DNA as they circulate throughout the body to seed new tumors in other tissues like the bone, liver and brain. But in early-stage breast cancer, these cells are, by definition, scarcer.

To address the problem, the research team, which included scientists at Arizona State University, the City of Hope, Mayo Clinic, and the Cancer Research UK Cambridge Institute, developed a new way to pick up elusive cancer DNA. They genetically sequenced tumor biopsy tissue from 33 women with stage 1, 2, or 3 breast cancer, most of whom received drug or chemotherapy treatment prior to getting surgery to remove their tumors. By comparing the tumor sequence to the sequence from the patients’ normal cells, the scientists isolated potential mutations that distinguished the cancer cells and identified those that were most likely to be so-called “founder mutations”—genetic aberrations present in the original cancer cells and carried into the resulting tumor.

On average, each patient harbored about 66 such founder mutations. For each patient, the scientists combined the founder mutations to form a personalized assay, which could then be used to pick up signs of breast cancer DNA in blood samples. Combining a number of mutations together turned out to be a more sensitive way to detect tumor DNA than trying to pick up a single or a small number of mutations in an already small number of tumor DNA fragments present in the blood.

They combined this approach with a new strategy for amplifying the scarce tumor DNA found in a blood sample by preserving the size of these snippets and attaching unique molecular identifiers to them to make them more easily detectable.

At the start of the study, TARDIS was able to find tumor DNA in the blood samples of all the patients; other liquid biopsies for breast cancer currently in development have reported picking up 50% to 75% of the cancer cases.

After the pre-surgery treatment TARDIS detected circulating tumor DNA in the blood in concentrations as low as 0.003%, or 100-fold more sensitive than other tests being developed.

“This is an important advance,” says Dr. Debu Tripathy, professor and chair of the breast medical oncology department at the University of Texas MD Anderson Cancer Center, who was not involved in the study. “This test can help identify those with early stage breast cancer who may still have residual cancer in their body that may not be detectable with standard scans.”

That could help guide treatment, by, for example, determining which patients require closer monitoring for recurrent growths. Because the sequencing identifies the genetic mutations contributing to the tumor, the test could also help doctors to decide which targeted drug therapies, which are designed to address specific cancer mutations, to prescribe for their patients.

Most importantly, the test could help women whose tumors are effectively eliminated by their pre-surgery treatment to avoid an operation altogether since the blood test would reassure her and her doctor that no residual tumor DNA remained.

“If we could really know with a more accurate degree of certainty that you don’t have residual disease, it would be help in saying that you don’t need any more therapy [including surgery],” says Dorraya El-Ashry, chief scientific officer of the Breast Cancer Research Foundation. ”Conversely, if you still had residual disease, if there is information from the test that can pinpoint the next therapy, that would also be better.”

Muhammed Murtaza, co-director of the center for non-invasive diagnostics at TGen, says TARDIS needs to be tested in a larger group of breast cancer patients before it can be rolled out to doctors’ offices. His team is planning to study the test’s efficacy in about 200 breast cancer patients, in order to clarify exactly what levels of tumor DNA found in the blood are most likely to lead to recurrence. They are also exploring how modified versions of TARDIS could be applied to other cancers, like esophageal, colorectal, pancreatic and prostate.

There’s even encouraging precedent for this sort of a liquid biopsy. Doctors routinely rely on a blood test for chronic myeloid leukemia, for example, to track patients’ response to targeted drugs that treat specific mutations driving the cancer. “Applying this same technology to more common solid cancers like breast cancer is the new frontier,” says Tripathy.

By Alice Park

Source: https://time.com

 

World Cancer day 4 th Feb — Success Inspirers’ World

World cancer day is a day we should remember,It’s a day for taking action ! Cancer is a word.Not a sentence John Diamond This day is celebrated as World Cancer day,where in, the world becomes one,united to fight cancer epidemic. This day is a reminder and an attempt to bring an awareness of cancer,in terms […]

via World Cancer day 4 th Feb — Success Inspirers’ World

A Cure For Cancer: How To Kill A Killer – The Guardian

1.jpg

Last month, the Nobel prize in medicine was awarded for two breakthrough scientific discoveries heralded as having “revolutionised cancer treatment”, and “fundamentally changed the way we view how cancer can be managed”. One of them went to a charismatic, harmonica-playing Texan named Jim Allison for his breakthrough advances in cancer immunotherapy. His discovery had resulted in transformative outcomes for cancer patients and a radical new direction for cancer research. And yet many cancer patients, and even some doctors, have hardly heard of cancer immunotherapy or refuse to believe it. Those who have struggle to make sense of the new menu of options and sort reasonable hope from overblown hype………..

Read more: https://www.theguardian.com/science/2018/nov/04/a-cure-for-cancer-how-to-kill-a-killer-revolutionary-immune-system-immunotherapy

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

Study of Cellphone Risks Finds ‘Some Evidence’ of Link to Cancer, at Least in Male Rats – William J. Broad

1.jpg

For decades, health experts have struggled to determine whether or not cellphones can cause cancer. On Thursday, a federal agency released the final results of what experts call the world’s largest and most costly experiment to look into the question. The study originated in the Clinton administration, cost $30 million and involved some 3,000 rodents. The experiment, by the National Toxicology Program, found positive but relatively modest evidence that radio waves from some types of cellphones could raise the risk that male rats develop brain cancer……..

Read more: https://www.nytimes.com/2018/11/01/health/cellphone-radiation-cancer.html

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

Eat These 7 Foods to Help Prevent Prostate Cancer – Natural Cures

Prostate cancer affects men more than any other kind of cancer. Almost 15% of men in the US suffer from it—a disproportionate number that could be significantly reduced. Some of the symptoms that accompany prostate cancer include: loss of bladder control, blood present in urine, and a burning sensation during urination. Studies show that a diet high in saturated fats, as well as being overweight increase the risk of prostate cancer.

In fact, more and more doctors are learning that a definite link exists between the foods we eat and the risk of cancer. These foods can be beneficial to anyone with a high risk of cancer:

1. Fresh Fish 2. Greens 3. Tomatoes 4. Coffee 5. Nuts 6. Pomegranates 7. Orange Vegetables Eating these foods can cut down on the risk of prostate cancer, but they can also have a positive effect on both a man’s waistline and his overall quality of life. It’s also important to note the presence of regular exercise reduces not only the risk, but also the degree of prostate cancer. Eat well and live well.

 

 

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

The DNA Detectives Hunting The Causes of Cancer – Kat Arney

1.jpg

Halfway up a hill overlooking the Great Rift Valley in western Kenya are two graves. One of them is a few years old now, bristling with bushy shrubs stretching bright green leaves towards a cloudless sky. The other is a freshly dug bed of rough red dirt planted with a white wooden cross. They are the final resting places of Emily’s mother and father, who died within four years of each other. Still a young woman, Emily now looks after her family’s rural homestead near Iten – a town famed for churning out long-distance runners and playing host to Mo Farah’s training camps.

Read more: https://mosaicscience.com/story/dna-detectives-cancer-genomics-mutational-signatures-mutographs/

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

Cancer & Ripe Bananas: How Bogus Claims Can Harm Your Health & The People You Love – Tanya Ha

1.jpg

According to the post: “Fully ripe bananas with brown patches on their skin produce a substance called tumor necrosis factor, which can eliminate abnormal cells. The darker the patches, the higher the banana’s ability to boost your immunity and lower the risk of cancer”. It was posted with the encouragement: “Share with the people you care about”. Some posts are helpful, such as those warning home renovators to check for asbestos. But there’s also a mountain of posts about a wide and weird range of things that allegedly cause cancer……

Read more: http://www.abc.net.au/news/health/2018-09-16/cancer-and-ripe-bananas-how-bogus-health-claims-hurt/10237738?section=health

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you

 

Exercise & Cancer Care: A Physiotherapist’s Guide to Fitness During & After Treatment – Catherine Granger

1.jpg

If you were diagnosed with cancer more than five or 10 years ago, you might have been told to rest and avoid physical activity.

Today, it’s a different story: we now know exercise benefits most people both during and after cancer treatment.

In May, Australian cancer experts launched a “world-first” position statement calling for exercise to be prescribed to all cancer patients as part of their routine treatment.

But how do you best keep physically active in the midst of illness, and later, remission?

Here are a few things to keep in mind when it comes to exercise in cancer care.

Exercise can alleviate side effects

While treatment pathways vary from person to person, cancer therapy (and cancer itself) can take a hefty toll on your physical and mental health.

Cancer-related fatigue is one of the most common side effects of cancer treatment and can occur at any stage of the disease. Other side effects include reduced fitness, muscle weakness, difficulty undertaking daily activities, as well as depression and anxiety.

Although some of these problems may begin before a cancer diagnosis, they are likely to be exacerbated during treatment.

The good news is that exercise can help to alleviate some of the side effects of cancer and its treatment, and improve outcomes for people with cancer.

Staying active helps to maintain or enhance your physical fitness, reduce fatigue, relieve mental distress and improve your overall quality of life.

Research shows exercise can help people with cancer tolerate aggressive treatments such as chemotherapy.

There is also data to suggest that in some types of cancer, such as breast, colon and prostate cancer, exercise may improve rates of survival.

Try a combination of cardio and weights

The are two types of exercise you need to focus on during (and after) cancer treatment: cardio exercise and resistance exercise.

Cardio exercise is all about getting your heart pumping and your whole body working. Think brisk walking, jogging, cycling, swimming and dancing.

Resistance exercise, on the other hand, is about strengthening your muscles. This can be done using weight machines, dumbbells, elastic bands or just gravity and the weight of your own body.

When it comes to cardio, 150 minutes of moderate intensity exercise per week is the goal. You might achieve this with 30 minutes of brisk walking or cycling (on an exercise bike) five times a week.

If you find 30 minutes in one session is too challenging, begin with a 10-minute brisk walk and slowly build your way up — either by extending the duration of your walk each time, or adding more walks into your day.

The intensity — or how hard you exercise — is important too. The easiest way to work out how intensely you’re exercising is by using the “walk and talk” test.

If you are walking for exercise, you need to be walking fast enough that you are getting a bit puffed (moderate intensity) — but not so fast that you can’t speak in full sentences (vigorous intensity).

Although vigorous intensity exercise gets your heart rate up (and requires only 75 minutes per week, compared to 150), we don’t recommend starting with this unless you are a very competent exerciser or have the support of a health professional.

When it comes to resistance training, research shows exercises should be done two or three times per week involving exercises that target the major muscle groups.

If you haven’t exercised for a long time, start off slow. And remember: when it comes to exercise, something is always better than nothing.

I’ve started exercising, but how do I stay motivated?

Staying motivated can be hard, especially on the days when you are busy running to and from hospital appointments, or sitting for hours in the hospital to receive chemotherapy.

It’s even harder on the days when symptoms like fatigue are at their worst.

The first thing to think about is what works for you. If you’re someone who likes tracking your own progress and striving to improve your fitness levels, measuring your daily step count might be a good option.

Watching how many steps you take each day and challenging yourself to reach a daily goal is a great way to keep motivated — and it helps you keep track of your daily activity.

If you have a smartphone, most come with a free health app that can track your daily step count.

Another way to maintain motivation is to use an exercise diary; many people find it really satisfying to tick a box for each day they exercise. Plus, it gives you the chance to marvel at your efforts at the end of each week.

While many people prefer to exercise alone, some people find it boring. If this is you, think about asking a friend to join you, or see if your community has a local walking group or exercise class for people with cancer.

What about after cancer, can I stop now?

No way! Keep it up. Or start again if you have stopped.

Exercise for people in remission — both immediately after treatment and in the long term — is really important. Surviving cancer means you are at risk of several other chronic diseases including diabetes and cardiovascular disease.

Evidence tells us that exercise helps prevent these diseases, plus a growing body of evidence suggests exercise has a role to play in preventing the cancer coming back.

Maintaining a healthy lifestyle after cancer is more important than ever.

If you are currently undergoing cancer treatment (or are due to start soon) and planning to exercise, it’s a good idea to speak with your GP first. They’ll be able to refer you to an exercise specialist with experience in cancer care, such as a physiotherapist or accredited exercise physiologist.

 

 

Your kindly Donations would be so effective in order to fulfill our future research and endeavors – Thank you
https://www.paypal.me/ahamidian

7 Tips for Coping with Emotions During & After Cancer Treatment — So You’ve Got Acute Blood Cancer…Join The Club!

According to the Canadian Cancer Society, the incidence of developing cancer increases after 50 years old. While I don’t have enough statistical information to disagree, young adults are falling victim to cancer as well…and they are faced with a slew of challenges as a result. When I was in the hospital, I met a 31 […]

via 7 Tips for Coping with Emotions During & After Cancer Treatment — So You’ve Got Acute Blood Cancer…Join The Club!

%d bloggers like this:
Skip to toolbar